The tumor suppressor LACTB remodels mitochondria to promote cytochrome c release and apoptosis.
Kamerkar SC, Kang T, Stan RV, Usherwood EJ, Higgs HN
Sci Adv. 2025 Nov 14;11(46):eadx7809. doi: 10.1126/sciadv.adx7809. Epub 2025 Nov 12.
PMID: 41223265
Targeting pyruvate metabolism generates distinct CD8+ T cell responses to gammaherpesvirus and B lymphoma.
Kang T, Usherwood YK, Reisz JA, Kamerkar SC, Culp-Hill R, Wilkins OM, Verissimo AF, Kolling FW 4th, Hung AM, Musial SC, Rosato PC, D'Alessandro A, Higgs HN, Usherwood EJ
JCI Insight. 2025 Aug 22;10(16) doi: 10.1172/jci.insight.187680. Epub 2025 Aug 22.
PMID: 40857407
Host Genetic Variation Has a Profound Impact on Immune Responses Mediating Control of Viral Load in Chronic Gammaherpesvirus Infection.
Holt EA, Waytashek CM, Sessions KJ, Asarian L, Lahue KG, Usherwood EJ, Teuscher C, Krementsov DN
J Immunol. 2023 Nov 15;211(10):1526-1539. doi: 10.4049/jimmunol.2300294.
PMID: 37819784
Characterizing control of memory CD8 T cell differentiation by BTB-ZF transcription factor Zbtb20.
Preiss NK, Kamal Y, Wilkins OM, Li C, Kolling FW 4th, Trask HW, Usherwood YK, Cheng C, Frost HR, Usherwood EJ
Life Sci Alliance. 2023 Sep;6(9) doi: 10.26508/lsa.202201683. Epub 2023 Jul 6.
PMID: 37414528
Mitochondrial dysfunction triggers actin polymerization necessary for rapid glycolytic activation.
Chakrabarti R, Fung TS, Kang T, Elonkirjo PW, Suomalainen A, Usherwood EJ, Higgs HN
J Cell Biol. 2022 Nov 7;221(11) doi: 10.1083/jcb.202201160. Epub 2022 Sep 14.
PMID: 36102863
Resident memory CD8(+) T cells in regional lymph nodes mediate immunity to metastatic melanoma.
Molodtsov AK, Khatwani N, Vella JL, Lewis KA, Zhao Y, Han J, Sullivan DE, Searles TG, Preiss NK, Shabaneh TB, Zhang P, Hawkes AR, Malik BT, Kolling FW 4th, Usherwood EJ, Wong SL, Phillips JD, Shirai K, Angeles CV, Yan S, Curiel TJ, Huang YH, Cheng C, Turk MJ
Immunity. 2021 Sep 14;54(9):2117-2132.e7. doi: 10.1016/j.immuni.2021.08.019.
PMID: 34525340
Endometrial Cancer Suppresses CD8+ T Cell-Mediated Cytotoxicity in Postmenopausal Women.
Patel MV, Shen Z, Rodriguez-Garcia M, Usherwood EJ, Tafe LJ, Wira CR
Front Immunol. 2021;12:657326. doi: 10.3389/fimmu.2021.657326. Epub 2021 Apr 23.
PMID: 33968059
Control of B Cell Lymphoma by Gammaherpesvirus-Induced Memory CD8 T Cells.
Preiss NK, Kang T, Usherwood YK, Huang YH, Branchini BR, Usherwood EJ
J Immunol. 2020 Dec 15;205(12):3372-3382. doi: 10.4049/jimmunol.2000734. Epub 2020 Nov 13.
PMID: 33188072
Zbtb20 Restrains CD8 T Cell Immunometabolism and Restricts Memory Differentiation and Antitumor Immunity.
Sun Y, Preiss NK, Valenteros KB, Kamal Y, Usherwood YK, Frost HR, Usherwood EJ
J Immunol. 2020 Nov 15;205(10):2649-2666. doi: 10.4049/jimmunol.2000459. Epub 2020 Sep 30.
PMID: 32998985
CD8(+) T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine.
Cho HS, Ha S, Shin HM, Reboldi A, Hall JA, Huh JR, Usherwood EJ, Berg LJ
Immunohorizons. 2020 Feb 7;4(2):57-71. doi: 10.4049/immunohorizons.1900093. Epub 2020 Feb 7.
PMID: 32034085