Oligosaccharyltransferase (OST) complex inhibition effectively treats rodent and human prions.
Beauchemin KS, Kun J, Groveman B, Williams K, Salerno F, Francomacaro LM, Robison P, Haigh CL, Supattapone S
PLoS Pathog. 2026 Jan 12;22(1):e1013867. doi: 10.1371/journal.ppat.1013867. Epub 2026 Jan 12.
PMID: 41525337
Genome-Wide Screens Identify Core Regulators of Cell Surface Prion Protein Expression.
Beauchemin KS, Supattapone S
bioRxiv. 2025 Dec 9; pii: 2025.12.07.692843. doi: 10.64898/2025.12.07.692843. Epub 2025 Dec 9.
PMID: 41427295
Convergent generation of atypical prions in knockin mouse models of genetic prion disease.
Mehra S, Bourkas ME, Kaczmarczyk L, Stuart E, Arshad H, Griffin JK, Frost KL, Walsh DJ, Supattapone S, Booth SA, Jackson WS, Watts JC
J Clin Invest. 2024 Aug 1;134(15) doi: 10.1172/JCI176344. Epub 2024 Aug 1.
PMID: 39087478
Anti-prion drugs do not improve survival in novel knock-in models of inherited prion disease.
Walsh DJ, Rees JR, Mehra S, Bourkas MEC, Kaczmarczyk L, Stuart E, Jackson WS, Watts JC, Supattapone S
PLoS Pathog. 2024 Apr;20(4):e1012087. doi: 10.1371/journal.ppat.1012087. Epub 2024 Apr 1.
PMID: 38557815
Correction: Emergence of Prions Selectively Resistant to Combination Drug Therapy.
Burke CM, Mark KMK, Kun J, Beauchemin KS, Supattapone S
PLoS Pathog. 2024 Jan;20(1):e1011919. doi: 10.1371/journal.ppat.1011919. Epub 2024 Jan 8.
PMID: 38190351
Anti-prion drugs do not improve survival in knock-in models of inherited prion disease.
Walsh DJ, Rees JR, Mehra S, Bourkas MEC, Kaczmarczyk L, Stuart E, Jackson WS, Watts JC, Supattapone S
bioRxiv. 2023 Sep 29; pii: 2023.09.28.559951. doi: 10.1101/2023.09.28.559951. Epub 2023 Sep 29.
PMID: 37808761
Phospholipid cofactor solubilization inhibits formation of native prions.
Schwind AM, Walsh DJ, Burke CM, Supattapone S
J Neurochem. 2023 Sep;166(5):875-884. doi: 10.1111/jnc.15930. Epub 2023 Aug 7.
PMID: 37551010
Cancer Epidemiology in the Northeastern United States (2013-2017).
Rees JR, Weiss JE, Gunn CM, Carlos HA, Dragnev NC, Supattapone EY, Tosteson ANA, Kraft SA, Vahdat LT, Peacock JL
Cancer Res Commun. 2023 Aug;3(8):1538-1550. doi: 10.1158/2767-9764.CRC-23-0152. Epub 2023 Aug 14.
PMID: 37583435
A single protective polymorphism in the prion protein blocks cross-species prion replication in cultured cells.
Arshad H, Patel Z, Amano G, Li LY, Al-Azzawi ZAM, Supattapone S, Schmitt-Ulms G, Watts JC
J Neurochem. 2023 Apr;165(2):230-245. doi: 10.1111/jnc.15739. Epub 2022 Dec 24.
PMID: 36511154
Conformational diversity in purified prions produced in vitro.
Walsh DJ, Schwind AM, Noble GP, Supattapone S
PLoS Pathog. 2023 Jan;19(1):e1011083. doi: 10.1371/journal.ppat.1011083. Epub 2023 Jan 10.
PMID: 36626391
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