Role of PLEXIND1/TGFβ Signaling Axis in Pancreatic Ductal Adenocarcinoma Progression Correlates with the Mutational Status of KRAS.
Vivekanandhan S, Madamsetty VS, Angom RS, Dutta SK, Wang E, Caulfield T, Pletnev AA, Upstill-Goddard R, Asmann YW, Chang D, Spaller MR, Mukhopadhyay D
Cancers (Basel). 2021 Aug 11;13(16) doi: 10.3390/cancers13164048. Epub 2021 Aug 11.
PMID: 34439202

Reducing dermal exposure to agrochemical carcinogens using a fluorescent dye-based intervention among subsistence farmers in rural Honduras.
Flynn TG, Dunaway CM, LaRochelle E, Lyons K, Kennedy LS, Romano ME, Li Z, Spaller MR, Cervinski MA, Bejarano S, Tsongalis GJ, Huyck KL
Int J Hyg Environ Health. 2021 May;234:113734. doi: 10.1016/j.ijheh.2021.113734. Epub 2021 Mar 31.
PMID: 33799075

Interaction Between CRIPT and PSD-95 Is Required for Proper Dendritic Arborization in Hippocampal Neurons.
Omelchenko A, Menon H, Donofrio SG, Kumar G, Chapman HM, Roshal J, Martinez-Montes ER, Wang TL, Spaller MR, Firestein BL
Mol Neurobiol. 2020 May;57(5):2479-2493. doi: 10.1007/s12035-020-01895-5. Epub 2020 Mar 9.
PMID: 32157575

PTEN recruitment controls synaptic and cognitive function in Alzheimer's models.
Knafo S, Sanchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, Klosi E, Faber EB, Chapman HM, Lozano-Montes L, Ortega-Molina A, Ordoñez-Gutierrez L, Wandosell F, Viña J, Dotti CG, Hall RA, Pulido R, Gerges NZ, Chan AM, Spaller MR, Serrano M, Venero C, Esteban JA
Nat Neurosci. 2016 Mar;19(3):443-53. doi: 10.1038/nn.4225. Epub 2016 Jan 18.
PMID: 26780512

Inhibition of N-Methyl-D-aspartate-induced Retinal Neuronal Death by Polyarginine Peptides Is Linked to the Attenuation of Stress-induced Hyperpolarization of the Inner Mitochondrial Membrane Potential.
Marshall J, Wong KY, Rupasinghe CN, Tiwari R, Zhao X, Berberoglu ED, Sinkler C, Liu J, Lee I, Parang K, Spaller MR, Huttemann M, Goebel DJ
J Biol Chem. 2015 Sep 4;290(36):22030-48. doi: 10.1074/jbc.M115.662791. Epub 2015 Jun 22.
PMID: 26100636

Chemically-Modified Peptides Targeting the PDZ Domain of GIPC as a Therapeutic Approach for Cancer.
Patra CR, Rupasinghe CN, Dutta SK, Bhattacharya S, Wang E, Spaller MR, Mukhopadhyay D
ACS Chem Biol. 2019 Oct 18;14(10):2327. doi: 10.1021/cb500865a. Epub 2015 Mar 10.
PMID: 25756300

GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways.
Bhattacharya S, Pal K, Sharma AK, Dutta SK, Lau JS, Yan IK, Wang E, Elkhanany A, Alkharfy KM, Sanyal A, Patel TC, Chari ST, Spaller MR, Mukhopadhyay D
PLoS One. 2014;9(12):e114409. doi: 10.1371/journal.pone.0114409. Epub 2014 Dec 3.
PMID: 25469510

Chemically modified peptide scaffolds target the CFTR-associated ligand PDZ domain.
Amacher JF, Zhao R, Spaller MR, Madden DR
PLoS One. 2014;9(8):e103650. doi: 10.1371/journal.pone.0103650. Epub 2014 Aug 19.
PMID: 25136860

Inhibition of endoglin-GIPC interaction inhibits pancreatic cancer cell growth.
Pal K, Pletnev AA, Dutta SK, Wang E, Zhao R, Baral A, Yadav VK, Aggarwal S, Krishnaswamy S, Alkharfy KM, Chowdhury S, Spaller MR, Mukhopadhyay D
Mol Cancer Ther. 2014 Oct;13(10):2264-75. doi: 10.1158/1535-7163.MCT-14-0291. Epub 2014 Aug 14.
PMID: 25125675

Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease.
Yedidi RS, Muhuhi JM, Liu Z, Bencze KZ, Koupparis K, O'Connor CE, Kovari IA, Spaller MR, Kovari LC
Biochem Biophys Res Commun. 2013 Sep 6;438(4):703-8. doi: 10.1016/j.bbrc.2013.07.117. Epub 2013 Aug 3.
PMID: 23921229

Impairment of TrkB-PSD-95 signaling in Angelman syndrome.
Cao C, Rioult-Pedotti MS, Migani P, Yu CJ, Tiwari R, Parang K, Spaller MR, Goebel DJ, Marshall J
PLoS Biol. 2013;11(2):e1001478. doi: 10.1371/journal.pbio.1001478. Epub 2013 Feb 12.
PMID: 23424281

Selection of heptapeptides that bind helix 69 of bacterial 23S ribosomal RNA.
Kaur M, Rupasinghe CN, Klosi E, Spaller MR, Chow CS
Bioorg Med Chem. 2013 Mar 1;21(5):1240-7. doi: 10.1016/j.bmc.2012.12.048. Epub 2013 Jan 10.
PMID: 23375098

Chemically modified peptides targeting the PDZ domain of GIPC as a therapeutic approach for cancer.
Patra CR, Rupasinghe CN, Dutta SK, Bhattacharya S, Wang E, Spaller MR, Mukhopadhyay D
ACS Chem Biol. 2012 Apr 20;7(4):770-9. doi: 10.1021/cb200536r. Epub 2012 Feb 15.
PMID: 22292614

RGS-GAIP-interacting protein controls breast cancer progression.
Wang L, Lau JS, Patra CR, Cao Y, Bhattacharya S, Dutta S, Nandy D, Wang E, Rupasinghe CN, Vohra P, Spaller MR, Mukhopadhyay D
Mol Cancer Res. 2010 Dec;8(12):1591-600. doi: 10.1158/1541-7786.MCR-10-0209. Epub 2010 Oct 27.
PMID: 21047775

A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia.
LeBlanc BW, Iwata M, Mallon AP, Rupasinghe CN, Goebel DJ, Marshall J, Spaller MR, Saab CY
Neuroscience. 2010 May 5;167(2):490-500. doi: 10.1016/j.neuroscience.2010.02.031. Epub 2010 Feb 16.
PMID: 20167266

Recognition of lysine-rich peptide ligands by murine cortactin SH3 domain: CD, ITC, and NMR studies.
Rubini C, Ruzza P, Spaller MR, Siligardi G, Hussain R, Udugamasooriya DG, Bellanda M, Mammi S, Borgogno A, Calderan A, Cesaro L, Brunati AM, Donella-Deana A
Biopolymers. 2010;94(3):298-306. doi: 10.1002/bip.21350.
PMID: 19921743

Selection of peptides that target the aminoacyl-tRNA site of bacterial 16S ribosomal RNA.
Li M, Duc AC, Klosi E, Pattabiraman S, Spaller MR, Chow CS
Biochemistry. 2009 Sep 8;48(35):8299-311. doi: 10.1021/bi900982t.
PMID: 19645415

Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth.
Muders MH, Vohra PK, Dutta SK, Wang E, Ikeda Y, Wang L, Udugamasooriya DG, Memic A, Rupasinghe CN, Baretton GB, Aust DE, Langer S, Datta K, Simons M, Spaller MR, Mukhopadhyay D
Clin Cancer Res. 2009 Jun 15;15(12):4095-103. doi: 10.1158/1078-0432.CCR-08-2837. Epub 2009 Jun 9.
PMID: 19509165

T7 phage display as a method of peptide ligand discovery for PDZ domain proteins.
Sharma SC, Memic A, Rupasinghe CN, Duc AC, Spaller MR
Biopolymers. 2009;92(3):183-93. doi: 10.1002/bip.21172.
PMID: 19235856

How do halogen substituents contribute to protein-binding interactions? A thermodynamic study of peptide ligands with diverse aryl halides.
Memic A, Spaller MR
Chembiochem. 2008 Nov 24;9(17):2793-5. doi: 10.1002/cbic.200800572.
PMID: 18985647

A chemical library approach to organic-modified peptide ligands for PDZ domain proteins: a synthetic, thermodynamic and structural investigation.
Udugamasooriya DG, Sharma SC, Spaller MR
Chembiochem. 2008 Jul 2;9(10):1587-9. doi: 10.1002/cbic.200800126.
PMID: 18506876

Conformational constraint in protein ligand design and the inconsistency of binding entropy.
Udugamasooriya DG, Spaller MR
Biopolymers. 2008 Aug;89(8):653-67. doi: 10.1002/bip.20983.
PMID: 18335423

[GIPC: a new target for therapy in pancreatic adenocarcinoma?].
Muders MH, Baretton GB, Aust DE, Dutta SK, Wang E, Ikeda Y, Spaller MR, Datta K, Mukhopadhyay D
Verh Dtsch Ges Pathol. 2007;91:286-93.
PMID: 18314626

Design, synthesis, and evaluation of linear and cyclic peptide ligands for PDZ10 of the multi-PDZ domain protein MUPP1.
Sharma SC, Rupasinghe CN, Parisien RB, Spaller MR
Biochemistry. 2007 Nov 6;46(44):12709-20. Epub 2007 Oct 16.
PMID: 17939682

Bivalent peptides as PDZ domain ligands.
Klosi E, Saro D, Spaller MR
Bioorg Med Chem Lett. 2007 Nov 15;17(22):6147-50. Epub 2007 Sep 12.
PMID: 17890086

A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95.
Saro D, Li T, Rupasinghe C, Paredes A, Caspers N, Spaller MR
Biochemistry. 2007 May 29;46(21):6340-52. Epub 2007 May 3.
PMID: 17474715

Act globally, think locally: systems biology addresses the PDZ domain.
Spaller MR
ACS Chem Biol. 2006 May 23;1(4):207-10.
PMID: 17163673

Expanding the synthetic method and structural diversity potential for the intramolecular Aza Diels-Alder cyclization.
Muhuhi J, Spaller MR
J Org Chem. 2006 Jul 21;71(15):5515-26.
PMID: 16839130

Targeting the PDZ domains of molecular scaffolds of transmembrane ion channels.
Piserchio A, Spaller M, Mierke DF
AAPS J. 2006 Jun 2;8(2):E396-401. Epub 2006 Jun 2.
PMID: 16796391

Monomeric yeast frataxin is an iron-binding protein.
Cook JD, Bencze KZ, Jankovic AD, Crater AK, Busch CN, Bradley PB, Stemmler AJ, Spaller MR, Stemmler TL
Biochemistry. 2006 Jun 27;45(25):7767-77.
PMID: 16784228

The interplay between structure-based design and combinatorial chemistry.
Rupasinghe CN, Spaller MR
Curr Opin Chem Biol. 2006 Jun;10(3):188-93. Epub 2006 Apr 17.
PMID: 16616591

Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane.
Gerges NZ, Backos DS, Rupasinghe CN, Spaller MR, Esteban JA
EMBO J. 2006 Apr 19;25(8):1623-34. Epub 2006 Apr 6.
PMID: 16601687

Bridged peptide macrocycles as ligands for PDZ domain proteins.
Udugamasooriya G, Saro D, Spaller MR
Org Lett. 2005 Mar 31;7(7):1203-6.
PMID: 15787467

(1)H, (15)N and (13)C backbone and side chain assignments of PSD-95 PDZ3 protein.
Ukpabi N, Sharma S, Spaller MR, Tsang P
J Biomol NMR. 2004 Sep;30(1):111-2.
PMID: 15452444

Thermodynamic analysis of a hydrophobic binding site: probing the PDZ domain with nonproteinogenic peptide ligands.
Saro D, Klosi E, Paredes A, Spaller MR
Org Lett. 2004 Sep 30;6(20):3429-32.
PMID: 15387515

Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide.
Piserchio A, Salinas GD, Li T, Marshall J, Spaller MR, Mierke DF
Chem Biol. 2004 Apr;11(4):469-73.
PMID: 15123241

Thermodynamic profiling of conformationally constrained cyclic ligands for the PDZ domain.
Li T, Saro D, Spaller MR
Bioorg Med Chem Lett. 2004 Mar 22;14(6):1385-8.
PMID: 15006367

Combinatorial synthetic design. Solution and polymer-supported synthesis of heterocycles via intramolecular aza Diels-Alder and imino alcohol cyclizations.
Spaller MR, Thielemann WT, Brennan PE, Bartlett PA
J Comb Chem. 2002 Sep-Oct;4(5):516-22.
PMID: 12217025

Synthetic strategies in combinatorial chemistry.
Spaller MR, Burger MT, Fardis M, Bartlett PA
Curr Opin Chem Biol. 1997 Jun;1(1):47-53.
PMID: 9667834

Expression and site-directed mutagenesis of the phosphatidylcholine-preferring phospholipase C of Bacillus cereus: probing the role of the active site Glu146.
Martin SF, Spaller MR, Hergenrother PJ
Biochemistry. 1996 Oct 1;35(39):12970-7.
PMID: 8841144