In pursuit of therapeutic agents for treating cancer and neurobiological disease states

The Spaller lab specializes in the study of protein-ligand and protein-protein interactions of biological and medicinal significance, focusing on those that regulate oncogenic and neuronal signal transduction pathways. Our efforts encompass aspects that are both fundamental—investigating the underlying molecular and cellular mechanisms—and applied—developing reagents that will serve as molecular probes in biological studies, or as compounds for use in drug development.

Although built upon a foundation of organic and peptide chemical synthesis, our research is interdisciplinary in nature, incorporating the methods of protein biochemistry, molecular biology and biophysics. Taken together, these approaches coalesce into a CHEMICAL BIOLOGY enterprise directed towards translational research, in support of discovering therapeutics for a range of cancer and neurobiological disorders.