Shoemaker Laboratory

We are interested in how unwanted cellular structures are eliminated from the cell. Specifically, we are most interested in autophagy. Autophagy is an intracellular degradation and recycling pathway that removes large, potentially toxic structures - such as damaged organelles or toxic protein aggregates. Defects in autophagy allow for the accumulation of toxic structures and contribute to many human diseases including neurodegeneration, cancer, cardiovascular disease, and aging. A better understanding of autophagy mechanisms will inform our understanding of how autophagy becomes dysregulated in disease and guide therapeutic attempts to ameliorate these deficiencies.

The LC3-interacting region of NBR1 is a protein interaction hub enabling optimal flux.
North BJ, Ohnstad AE, Ragusa MJ, Shoemaker CJ
bioRxiv. 2024 May 9; pii: 2024.05.09.593318. doi: 10.1101/2024.05.09.593318. Epub 2024 May 9.
PMID: 38766171

An unexpected journey for BNIP3.
Delgado JM, Shoemaker CJ
Autophagy. 2024 Jun;20(6):1447-1448. doi: 10.1080/15548627.2024.2312038. Epub 2024 Mar 6.
PMID: 38449384

Response to Bruton's tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy.
Phelan JD, Scheich S, Choi J, Wright GW, Haupl B, Young RM, Rieke SA, Pape M, Ji Y, Urlaub H, Bolomsky A, Doebele C, Zindel A, Wotapek T, Kasbekar M, Collinge B, Huang DW, Coulibaly ZA, Morris VM, Zhuang X, Enssle JC, Yu X, Xu W, Yang Y, Zhao H, Wang Z, Tran AD, Shoemaker CJ, Shevchenko G, Hodson DJ, Shaffer AL 3rd, Staudt LM, Oellerich T
Cancer Cell. 2024 Feb 12;42(2):238-252.e9. doi: 10.1016/j.ccell.2023.12.019. Epub 2024 Jan 11.
PMID: 38215749