Shoemaker Laboratory

We are interested in how unwanted cellular structures are eliminated from the cell. Specifically, we are most interested in autophagy. Autophagy is an intracellular degradation and recycling pathway that removes large, potentially toxic structures - such as damaged organelles or toxic protein aggregates. Defects in autophagy allow for the accumulation of toxic structures and contribute to many human diseases including neurodegeneration, cancer, cardiovascular disease, and aging. A better understanding of autophagy mechanisms will inform our understanding of how autophagy becomes dysregulated in disease and guide therapeutic attempts to ameliorate these deficiencies.

The LC3-interacting region of NBR1 is a protein interaction hub enabling optimal flux.
North BJ, Ohnstad AE, Ragusa MJ, Shoemaker CJ
J Cell Biol. 2025 Apr 7;224(4) doi: 10.1083/jcb.202407105. Epub 2025 Feb 10.
PMID: 39928048

The LC3-interacting region of NBR1 is a protein interaction hub enabling optimal flux.
North BJ, Ohnstad AE, Ragusa MJ, Shoemaker CJ
bioRxiv. 2024 May 9; pii: 2024.05.09.593318. doi: 10.1101/2024.05.09.593318. Epub 2024 May 9.
PMID: 38766171

An unexpected journey for BNIP3.
Delgado JM, Shoemaker CJ
Autophagy. 2024 Jun;20(6):1447-1448. doi: 10.1080/15548627.2024.2312038. Epub 2024 Mar 6.
PMID: 38449384