Skopelja-Gardner Laboratory


The lab presents their new research at the 21st Century Lupus Conference: “The Role of Neutrophils in the Clinical Severity of Lupus Nephritis Patients with Concurrent Skin Disease”: Authors: Lais Osmani, Jason Pettus, Alecia Roy, Sladjana Skopelja-Gardner ”

Study Reveals New Insights into the Link Between Sunlight Exposure and Kidney Damage in Lupus

new collaborative study from researchers at the Geisel School of Medicine at Dartmouth and the University of Washington (UW) and published in the Proceedings of the National Academy of Sciences (PNAS), reveals unexpected insights into how skin exposure to ultraviolet (UV) light can worsen clinical symptoms in autoimmune diseases such as lupus.

Lupus, an autoimmune disease that can cause inflammation of the joints, skin, kidneys, blood cells, brain, heart and lungs, is caused when the immune system attacks its own tissue.

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Selected Publications

Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation.
Skopelja-Gardner S, Tai J, Sun X, Tanaka L, Kuchenbecker JA, Snyder JM, Kubes P, Mustelin T, Elkon KB
Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2019097118. doi: 10.1073/pnas.2019097118
PMID: 33397815

The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent.
Skopelja-Gardner S, An J, Tai J, Tanaka L, Sun X, Hermanson P, Baum R, Kawasumi M, Green R, Gale M Jr, Kalus A, Werth VP, Elkon KB
Sci Rep. 2020 May 13;10(1):7908. doi: 10.1038/s41598-020-64865-w. Epub 2020 May 13.
PMID: 32404939

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