Jomkuan (Lynn) Theprungsirikul, PhD
I graduated from Duke University in 2014 with a BS in Biology. From sophomore to senior year of my undergraduate studies, I worked in the Cellular Biology lab of Dr. Zhen-Ming Pei to investigate the hyperosmolality-gated calcium-permeable channel and its function in osmosensing in Arabidopsis. Shortly after graduation, I began to work in Dr. Shyni Varghese's Bio-Inspired Materials and Stem Cell Engineering lab at UC San Diego. During my time there, I and a group of graduate students developed 3D cardiac microtissues within a microfluidic device with the ability to quantify real-time contractile stress measurements for use in drug discovery and development. We also developed a cancer-on-a-chip platform that recapitulates the blood vessel-cancer tissue interface through co-culturing of endothelial and cancer cells for use as an oncologic drug-screening platform or in vitro systems for immunooncology. In 2016, I joined the Molecular and Cellular Biology Program at Dartmouth. I joined Dr. William Rigby's lab in 2017 to pursue my PhD. My research focus in Dr. Rigby's lab is on autoimmunity in cystic fibrosis patients during Pseudomonas aeruginosa infection.
Selected Publications
Differential Enhancement of Neutrophil Phagocytosis by Anti–Bactericidal/Permeability-Increasing Protein Antibodies
Theprungsirikul J, Skopelja-Gardner S, Wierzbicki RM, Sessions KJ, Rigby WFC. Differential Enhancement of Neutrophil Phagocytosis by Anti–Bactericidal/Permeability-Increasing Protein Antibodies. J Immunol. 2021. DOI: 10.4049/jimmunol.2100378
Killing three birds with one BPI: Bactericidal, opsonic, and anti-inflammatory functions.
Theprungsirikul J, Skopelja-Gardner S, Rigby WFC. Journal of Translational Autoimmunity. 2021. DOI: 10.1016/j.jtauto.2021.100105
Bactericidal/Permeability-Increasing Protein Preeminently Mediates Clearance of Pseudomonas aeruginosa In Vivo via CD18-Dependent Phagocytosis.
Theprungsirikul J, Skopelja-Gardner S, Burns AS, Wierzbicki RM, Rigby WFC
Front Immunol. 2021;12:659523. doi: 10.3389/fimmu.2021.659523. Epub 2021 Apr 26.
PMID: 33981306
Low-Avidity Autoantibodies against Bactericidal/Permeability-Increasing Protein Occur in Gram-Negative and Gram-Positive Bacteremia.
Theprungsirikul J, Thaden JT, Wierzbicki RM, Burns AS, Skopelja-Gardner S, Fowler VG Jr, Winthrop KL, Martin IW, Rigby WFC
Infect Immun. 2020 Sep 18;88(10) doi: 10.1128/IAI.00444-20. Epub 2020 Sep 18.
PMID: 32747603
An Engineered Tumor-on-a-Chip Device with Breast Cancer-Immune Cell Interactions for Assessing T-cell Recruitment.
Aung A, Kumar V, Theprungsirikul J, Davey SK, Varghese S
Cancer Res. 2020 Jan 15;80(2):263-275. doi: 10.1158/0008-5472.CAN-19-0342. Epub 2019 Nov 19.
PMID: 31744818
Regulation of Pseudomonas aeruginosa-Mediated Neutrophil Extracellular Traps.
Skopelja-Gardner S, Theprungsirikul J, Lewis KA, Hammond JH, Carlson KM, Hazlett HF, Nymon A, Nguyen D, Berwin BL, Hogan DA, Rigby WFC
Front Immunol. 2019;10:1670. doi: 10.3389/fimmu.2019.01670. Epub 2019 Jul 18.
PMID: 31379861
Dissociation of systemic and mucosal autoimmunity in cystic fibrosis.
Theprungsirikul J, Skopelja-Gardner S, Meagher RE, Clancy JP, Zemanick ET, Ashare A, Rigby WFC
J Cyst Fibros. 2020 Mar;19(2):196-202. doi: 10.1016/j.jcf.2019.06.006. Epub 2019 Jun 28.
PMID: 31262645
Autoimmunity to bactericidal/permeability-increasing protein in bronchiectasis exhibits a requirement for Pseudomonas aeruginosa IgG response.
Skopelja-Gardner S, Theprungsirikul J, Meagher RE, Beliveau CM, Bradley KE, Avery M, Henkle E, Siegel S, Gifford AH, Winthrop KL, Rigby WFC
Eur Respir J. 2019 Feb;53(2) pii: 1801891. doi: 10.1183/13993003.01891-2018. Epub 2019 Feb 7.
PMID: 30385530
Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform.
Aung A, Theprungsirikul J, Lim HL, Varghese S
Lab Chip. 2016 May 21;16(10):1886-98. doi: 10.1039/c6lc00184j. Epub 2016 Apr 21.
PMID: 27097908
3D cardiac μtissues within a microfluidic device with real-time contractile stress readout.
Aung A, Bhullar IS, Theprungsirikul J, Davey SK, Lim HL, Chiu YJ, Ma X, Dewan S, Lo YH, McCulloch A, Varghese S
Lab Chip. 2016 Jan 7;16(1):153-62. doi: 10.1039/c5lc00820d. Epub 2015 Nov 20.
PMID: 26588203
OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis.
Yuan F, Yang H, Xue Y, Kong D, Ye R, Li C, Zhang J, Theprungsirikul L, Shrift T, Krichilsky B, Johnson DM, Swift GB, He Y, Siedow JN, Pei ZM
Nature. 2014 Oct 16;514(7522):367-71. doi: 10.1038/nature13593. Epub 2014 Aug 27.
PMID: 25162526