Dr. Jonathan D. Jones, MD
Scientist
I completed my MD degree at the University of Utah in 2002. I then came to Dartmouth-Hitchcock Medical Center as a resident in internal medicine. After completing my residency in 2005, I worked for 4 years as a hospitalist in Boise, ID. I returned to DHMC in 2009 for a rheumatology fellowship. During this fellowship I worked in the Rigby lab. From 2011-12 I did a post-doc fellowship in the Rigby lab, and identified a unique process occurring to B cells in the presence of the monoclonal antibody rituximab. This process is termed trogocytosis. I continued to work in Dr. Rigby's lab since joining the rheumatology faculty at DHMC in 2012. My research focus is on better understanding the role of trogocytosis in treatment of autoimmune conditions, and in identifying rheumatoid arthritis subsets through differing antibody and chemokine profiles. In addition, I participate in several clinical trials in the rheumatology clinic.
Selected Publications
Brief Report: Anti-Carbamylated Protein Antibodies in Rheumatoid Arthritis Patients Are Reactive With Specific Epitopes of the Human Fibrinogen β-Chain.
Jones JD, Hamilton BJ, Rigby WFC
Arthritis Rheumatol. 2017 Jul;69(7):1381-1386. doi: 10.1002/art.40098. Epub 2017 Jun 5.
PMID: 28296337
Induction of interleukin-6 production by rituximab in human B cells.
Jones JD, Hamilton BJ, Skopelja S, Rigby WF
Arthritis Rheumatol. 2014 Nov;66(11):2938-46. doi: 10.1002/art.38798.
PMID: 25080282
Serum C-X-C motif chemokine 13 is elevated in early and established rheumatoid arthritis and correlates with rheumatoid factor levels.
Jones JD, Hamilton BJ, Challener GJ, de Brum-Fernandes AJ, Cossette P, Liang P, Masetto A, Menard HA, Carrier N, Boyle DL, Rosengren S, Boire G, Rigby WF
Arthritis Res Ther. 2014 Apr 25;16(2):R103. doi: 10.1186/ar4552. Epub 2014 Apr 25.
PMID: 24766912
A rheumatoid factor paradox: inhibition of rituximab effector function.
Jones JD, Shyu I, Newkirk MM, Rigby WF
Arthritis Res Ther. 2013 Jan 25;15(1):R20. doi: 10.1186/ar4152. Epub 2013 Jan 25.
PMID: 23351360
Rituximab mediates loss of CD19 on B cells in the absence of cell death.
Jones JD, Hamilton BJ, Rigby WF
Arthritis Rheum. 2012 Oct;64(10):3111-8. doi: 10.1002/art.34560.
PMID: 22674374
Unusual case of a swollen painful toe in a young man.
Jones JD, Albert DA, Thadani V, Rigby WF
Arthritis Care Res (Hoboken). 2012 Feb;64(2):298-302. doi: 10.1002/acr.20603.
No abstract available.
PMID: 22278969