Jakubzick Lab

The Jakubzick lab mainly focuses on understanding mononuclear phagocytes (MPs) in homeostasis and inflammatory conditions. However, sometimes science leads us into exciting new research areas, such as understanding the role of natural antibody-producing B cells in cancer and their effects on innate and adaptive immunity.

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Natural antibodies drive type 2 immunity in response to damage associated molecular patterns.
Mara AB, Rawat K, King WT, Jakubzick CV
JCI Insight. 2024 Mar 12; pii: e177230. doi: 10.1172/jci.insight.177230. Epub 2024 Mar 12.
PMID: 38470489

Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species.
Han J, Gallerand A, Erlich EC, Helmink BA, Mair I, Li X, Eckhouse SR, Dimou FM, Shakhsheer BA, Phelps HM, Chan MM, Mintz RL, Lee DD, Schilling JD, Finlay CM, Allen JE, Jakubzick CV, Else KJ, Onufer EJ, Zhang N, Randolph GJ
Nat Immunol. 2024 Jan;25(1):155-165. doi: 10.1038/s41590-023-01688-7. Epub 2023 Dec 15.
PMID: 38102487

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