Jakubzick Lab

The Jakubzick lab mainly focuses on understanding mononuclear phagocytes (MPs) in homeostasis and inflammatory conditions. However, sometimes science leads us into exciting new research areas, such as understanding the role of natural antibody-producing B cells in cancer and their effects on innate and adaptive immunity.

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CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes.
Rawat K, Tewari A, Li X, Mara AB, King WT, Gibbings SL, Nnam CF, Kolling FW, Lambrecht BN, Jakubzick CV
J Exp Med. 2023 Jun 5;220(6) pii: e20222129. doi: 10.1084/jem.20222129. Epub 2023 Mar 22.
PMID: 36946983

Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes.
Gainullina A, Mogilenko DA, Huang LH, Todorov H, Narang V, Kim KW, Yng LS, Kent A, Jia B, Seddu K, Krchma K, Wu J, Crozat K, Tomasello E, Dress R, See P, Scott C, Gibbings S, Bajpai G, Desai JV, Maier B, This S, Wang P, Aguilar SV, Poupel L, Dussaud S, Zhou TA, Angeli V, Blander JM, Choi K, Dalod M, Dzhagalov I, Gautier EL, Jakubzick C, Lavine K, Lionakis MS, Paidassi H, Sieweke MH, Ginhoux F, Guilliams M, Benoist C, Merad M, Randolph GJ, Sergushichev A, Artyomov MN, ImmGen Consortium
Cell Rep. 2023 Jan 27;42(2):112046. doi: 10.1016/j.celrep.2023.112046. Epub 2023 Jan 27.
PMID: 36708514

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