Jakubzick Lab

The Jakubzick lab mainly focuses on understanding mononuclear phagocytes (MPs) in homeostasis and inflammatory conditions. However, sometimes science leads us into exciting new research areas, such as understanding the role of natural antibody-producing B cells in cancer and their effects on innate and adaptive immunity.

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A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair.
Salm L, Lopez MA, Jenkins E, Shim R, Tejada O, Abou Mehrem B, Huang S, Etemadi Nezhad P, Derakhshani A, Lee WY, Nusse Y, Mewburn JB, Noskovicova N, Bayer J, Rashid MU, Li X, Baltaci Z, Young D, Carneiro MB, Fritzsche M, Jakubzick CV, Peters NC, Deniset JF, Zindel J, Dufour A, Yipp BG, Ditlev JA, Dustin ML, Canton J, Kubes P
J Exp Med. 2026 Aug 3;223(8) pii: e20260410. doi: 10.1084/jem.20260410. Epub 2026 Jul 22.
PMID: 42484560

Alveolar macrophage subtypes express cholesterol and inflammation genes in cystic fibrosis.
Li X, Kolling FW, Aridgides D, Gwilt L, Mellinger D, Jakubzick CV, Ashare A
Life Sci Alliance. 2026 Jul;9(7) doi: 10.26508/lsa.202503482. Epub 2026 Apr 30.
PMID: 42061984

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