A type VI secretion system in Burkholderia species cenocepacia and orbicola triggers distinct macrophage death pathways independent of the pyrin inflammasome.
Loeven NA, Dabi C, Pennington JP, Reuven AD, McGee AP, Mwaura BW, Bliska JB
Infect Immun. 2024 Dec 10;92(12):e0031624. doi: 10.1128/iai.00316-24. Epub 2024 Oct 31.
PMID: 39480100
A Type VI Secretion System in Burkholderia Species cenocepacia and orbicola Triggers Distinct Macrophage Death Pathways Independent of the Pyrin Inflammasome.
Loeven NA, Reuven AD, McGee AP, Dabi C, Mwaura BW, Bliska JB
bioRxiv. 2024 May 20; pii: 2023.09.28.559184. doi: 10.1101/2023.09.28.559184. Epub 2024 May 20.
PMID: 38826213
ExoS Effector in Pseudomonas aeruginosa Hyperactive Type III Secretion System Mutant Promotes Enhanced Plasma Membrane Rupture in Neutrophils.
Reuven AD, Mwaura BW, Bliska JB
bioRxiv. 2024 Jan 25; pii: 2024.01.24.577040. doi: 10.1101/2024.01.24.577040. Epub 2024 Jan 25.
PMID: 38328038
Phosphoprotein phosphatase activity positively regulates oligomeric pyrin to trigger inflammasome assembly in phagocytes.
Malik HS, Magnotti F, Loeven NA, Delgado JM, Kettenbach AN, Henry T, Bliska JB
mBio. 2023 Oct 31;14(5):e0206623. doi: 10.1128/mbio.02066-23. Epub 2023 Oct 3.
PMID: 37787552
Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins.
Oh C, Li L, Verma A, Reuven AD, Miao EA, Bliska JB, Aachoui Y
Cell Rep. 2022 Nov 22;41(8):111688. doi: 10.1016/j.celrep.2022.111688.
PMID: 36417874
Correction: γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans.
Chu TH, Khairallah C, Shieh J, Cho R, Qiu Z, Zhang Y, Eskiocak O, Thanassi DG, Kaplan MH, Beyaz S, Yang VW, Bliska JB, Sheridan BS
PLoS Pathog. 2022 May;18(5):e1010586. doi: 10.1371/journal.ppat.1010586. Epub 2022 May 25.
PMID: 35613102
Role of the Yersinia pseudotuberculosis Virulence Plasmid in Pathogen-Phagocyte Interactions in Mesenteric Lymph Nodes.
Bliska JB, Brodsky IE, Mecsas J
EcoSal Plus. 2021 Dec 15;9(2):eESP00142021. doi: 10.1128/ecosalplus.ESP-0014-2021. Epub 2021 Oct 27.
PMID: 34910573
γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans.
Chu TH, Khairallah C, Shieh J, Cho R, Qiu Z, Zhang Y, Eskiocak O, Thanassi DG, Kaplan MH, Beyaz S, Yang VW, Bliska JB, Sheridan BS
PLoS Pathog. 2021 Dec;17(12):e1010103. doi: 10.1371/journal.ppat.1010103. Epub 2021 Dec 6.
PMID: 34871329
The Burkholderia cenocepacia Type VI Secretion System Effector TecA Is a Virulence Factor in Mouse Models of Lung Infection.
Loeven NA, Perault AI, Cotter PA, Hodges CA, Schwartzman JD, Hampton TH, Bliska JB
mBio. 2021 Oct 26;12(5):e0209821. doi: 10.1128/mBio.02098-21. Epub 2021 Sep 28.
PMID: 34579569
Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions.
O'Toole GA, Crabbe A, Kummerli R, LiPuma JJ, Bomberger JM, Davies JC, Limoli D, Phelan VV, Bliska JB, DePas WH, Dietrich LE, Hampton TH, Hunter R, Khursigara CM, Price-Whelan A, Ashare A, Cramer RA, Goldberg JB, Harrison F, Hogan DA, Henson MA, Madden DR, Mayers JR, Nadell C, Newman D, Prince A, Rivett DW, Schwartzman JD, Schultz D, Sheppard DC, Smyth AR, Spero MA, Stanton BA, Turner PE, van der Gast C, Whelan FJ, Whitaker R, Whiteson K
mBio. 2021 Oct 26;12(5):e0176321. doi: 10.1128/mBio.01763-21. Epub 2021 Sep 21.
PMID: 34544277