Geisel School of Medicine at Dartmouth
Department of Microbiology and Immunology
525 Remsen Building
66 College Street
Hanover, NH 03755
Tel: 603-650-1674 (office)
Tel: 603-650-1675 (lab)
Email: james.bliska@dartmouth.edu
The long-term aim of research in the Bliska Lab has been to understand how bacterial effectors that are secreted into infected leukocytes promote pathogenesis or elicit host protection. Our current research is focused on bacteria that use type III or type VI secretion systems to deliver effectors into phagocytic leukocytes (monocytes, macrophages, neutrophils).
Of particular interest are effectors that interact with the RhoA-pyrin signaling pathway in phagocytes. Several effectors promote pathogenesis by specifically inactivating RhoA, a small GTPase and regulator of cellular processes such as phagocytosis.
Phosphoprotein phosphatase activity positively regulates oligomeric pyrin to trigger inflammasome assembly in phagocytes.
Malik HS, Magnotti F, Loeven NA, Delgado JM, Kettenbach AN, Henry T, Bliska JB
mBio. 2023 Oct 3;14(5):e0206623. doi: 10.1128/mbio.02066-23. Epub 2023 Oct 3.
PMID: 37787552
Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins.
Oh C, Li L, Verma A, Reuven AD, Miao EA, Bliska JB, Aachoui Y
Cell Rep. 2022 Nov 22;41(8):111688. doi: 10.1016/j.celrep.2022.111688.
PMID: 36417874
Geisel School of Medicine at Dartmouth
Department of Microbiology and Immunology
525 Remsen Building
66 College Street
Hanover, NH 03755
Tel: 603-650-1674 (office)
Tel: 603-650-1675 (lab)
Email: james.bliska@dartmouth.edu
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