The secretory pathway gets a molecular framework.
Barlowe C
Nat Rev Mol Cell Biol. 2025 Dec;26(12):907. doi: 10.1038/s41580-025-00912-6.
PMID: 41102338
The Erv41-Erv46 complex serves as a retrograde receptor to retrieve misfolded secretory proteins that have escaped from the ER.
Fuesler JA, Blais JR, Barlowe C
Mol Biol Cell. 2025 Jul 1;36(7):ar80. doi: 10.1091/mbc.E25-02-0090. Epub 2025 May 6.
PMID: 40327065
The C-terminus of the cargo receptor Erv14 affects COPII vesicle formation and cargo delivery.
Lagunas-Gomez D, Yañez-Dominguez C, Zavala-Padilla G, Barlowe C, Pantoja O
J Cell Sci. 2023 Feb 1;136(3) doi: 10.1242/jcs.260527. Epub 2023 Feb 6.
PMID: 36651113
Molecular dissection of the Erv41-Erv46 retrograde receptor reveals a conserved cysteine-rich region in Erv46 required for retrieval activity.
Keiser KJ, Barlowe C
Mol Biol Cell. 2020 Feb 1;31(3):209-220. doi: 10.1091/mbc.E19-08-0484. Epub 2019 Dec 11.
PMID: 31825724
Twenty-five years after coat protein complex II.
Barlowe C
Mol Biol Cell. 2020 Jan 1;31(1):3-6. doi: 10.1091/mbc.E19-11-0621.
PMID: 31887067
Conserved juxtamembrane domains in the yeast golgin Coy1 drive assembly of a megadalton-sized complex and mediate binding to tethering and SNARE proteins.
Anderson NS, Barlowe C
J Biol Chem. 2019 Jun 21;294(25):9690-9705. doi: 10.1074/jbc.RA119.008107. Epub 2019 May 9.
PMID: 31073031
Lysophospholipids Facilitate COPII Vesicle Formation.
Melero A, Chiaruttini N, Karashima T, Riezman I, Funato K, Barlowe C, Riezman H, Roux A
Curr Biol. 2018 Jun 18;28(12):1950-1958.e6. doi: 10.1016/j.cub.2018.04.076. Epub 2018 Jun 7.
PMID: 29887313
The Golgin protein Coy1 functions in intra-Golgi retrograde transport and interacts with the COG complex and Golgi SNAREs.
Anderson NS, Mukherjee I, Bentivoglio CM, Barlowe C
Mol Biol Cell. 2017 Aug 9;28(20):2686-700. doi: 10.1091/mbc.E17-03-0137. Epub 2017 Aug 9.
PMID: 28794270
Cargo Capture and Bulk Flow in the Early Secretory Pathway.
Barlowe C, Helenius A
Annu Rev Cell Dev Biol. 2016 Oct 6;32:197-222. Epub 2016 Jun 8.
PMID: 27298089
Overexpression of Sly41 suppresses COPII vesicle-tethering deficiencies by elevating intracellular calcium levels.
Mukherjee I, Barlowe C
Mol Biol Cell. 2016 May 15;27(10):1635-49. doi: 10.1091/mbc.E15-10-0704. Epub 2016 Mar 30.
PMID: 27030673
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