We are located on the 7th floor of the Rubin Building in Dartmouth-Hitchcock Medical Center
Office: Rubin 732
603.653.6125 (office)
Rosato Laboratory
Featured
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GBMtetramer
Research
Tissue resident memory T cells (TRM) combine the exquisite specificity of adaptive immunity, with rapid frontline antiviral functions conventionally executed by innate immune cells.
Our lab is interested in understanding the function and regulation of TRM in distinct tissue environments to be able to contextualize their role in cancer, infection and autoimmunity.
Our current focuses:
• TRM in the brain
• TRM as a brain tumor immunotherapy
• TRM and oncolytic viral therapy
Recent Publications
Intratumoral T cell activation kills tumors regardless of T cell specificity.
Ghirardelli Smith OC, Dao TT, Gavil NV, O'Flanagan SD, Rubin AJ, Nguyen S, Watowich MB, Liu N, Weyu E, Quarnstrom CF, Soerens AG, Joag V, Rosato PC, Krummel MF, Geller MA, Miller JS, Giubellino A, Vezys V, Shalek AK, Masopust D
Nat Immunol. 2026 Oct;27(10):2134-2142. doi: 10.1038/s41590-026-02642-z. Epub 2026 Sep 8.
PMID: 42711529
Common viral infections seed regionally distinct resident memory T cells in the human CNS.
Degefu HN, Searles TG, Chen T, Musial SC, Isaacs JF, Kleist SA, Yang S, Ford MA, Kolling FW, Turk MJ, Skorput AGJ, Lin CC, Zanazzi GJ, Hong J, Song L, Rosato PC
bioRxiv. 2026 Sep 27; pii: 2026.09.21.753190. doi: 10.64898/2026.09.21.753190. Epub 2026 Sep 27.
PMID: 42818212
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