We are located on the 7th floor of the Rubin Building in Dartmouth-Hitchcock Medical Center
Office: Rubin 732
603.653.6125 (office)
Rosato Laboratory
Featured
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GBMtetramer
Research
Tissue resident memory T cells (TRM) combine the exquisite specificity of adaptive immunity, with rapid frontline antiviral functions conventionally executed by innate immune cells.
Our lab is interested in understanding the function and regulation of TRM in distinct tissue environments to be able to contextualize their role in cancer, infection and autoimmunity.
Our current focuses:
• TRM in the brain
• TRM as a brain tumor immunotherapy
• TRM and oncolytic viral therapy
Recent Publications
Intratumoral T cell activation kills tumors regardless of T cell specificity.
Ghirardelli Smith OC, Dao TT, Gavil NV, O'Flanagan SD, Rubin AJ, Nguyen S, Watowich MB, Liu N, Weyu E, Quarnstrom CF, Soerens AG, Joag V, Rosato PC, Krummel MF, Geller MA, Miller JS, Giubellino A, Vezys V, Shalek AK, Masopust D
Nat Immunol. 2026 Sep 8; doi: 10.1038/s41590-026-02642-z. Epub 2026 Sep 8.
PMID: 42711529
Glioblastoma Subtypes Exhibit Distinct Migration Mechanics and Immune Responses.
Shamsan GA, Liu CJ, Braman BC, Li R, Rathe SK, Sarver AL, Ghaderi N, McMahon M, Klank RL, Tschida BR, McFarren SJ, Rosato PC, Masopust D, Sarkaria JN, Clark HB, Rosenfeld S, Largaespada DA, Odde DJ
Cancer Res Commun. 2026 Aug 1;6(8):1898-1915. doi: 10.1158/2767-9764.CRC-25-0579.
PMID: 42447444
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