Two main issues confound the treatment of basal-like breast cancers, as well as other carcinomas. Firstly, most deaths from carcinomas (~90%) result from metastatic spread of the disease to distant sites rather than from the primary tumors. Secondly, the development of therapeutic resistance to initially treated tumors results in the relapse of cancers into more aggressive forms. Both of these properties of aggressive carcinomas can be traced to intrinsic intratumoral heterogeneity, which can arise through various mechanisms, prominent among these being the presence of subpopulations of cancer stem cells (CSCs) in carcinomas. Several lines of evidence indicate that these cells are intrinsically more resistant to many forms of conventional therapy and, at the same time, capable of regenerating tumor regrowth following cessation of therapy.
Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance.
Barbier V, Erbani J, Fiveash C, Davies JM, Tay J, Tallack MR, Lowe J, Magnani JL, Pattabiraman DR, Perkins AC, Lisle J, Rasko JEJ, Levesque JP, Winkler IG
Nat Commun. 2020 Apr 27;11(1):2042. doi: 10.1038/s41467-020-15817-5. Epub 2020 Apr 27.
PMID: 32341362
Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B.
Daffis S, Balsitis S, Chamberlain J, Zheng J, Santos R, Rowe W, Ramakrishnan D, Pattabiraman D, Spurlock S, Chu R, Kang D, Mish M, Ramirez R, Li L, Li B, Ma S, Hung M, Voitenleitner C, Yon C, Suresh M, Menne S, Cote P, Delaney WE 4th, Mackman R, Fletcher SP
Hepatology. 2020 Apr 4; doi: 10.1002/hep.31255. Epub 2020 Apr 4.
PMID: 32246499
Recovering Gene Interactions from Single-Cell Data Using Data Diffusion.
van Dijk D, Sharma R, Nainys J, Yim K, Kathail P, Carr AJ, Burdziak C, Moon KR, Chaffer CL, Pattabiraman D, Bierie B, Mazutis L, Wolf G, Krishnaswamy S, Pe'er D
Cell. 2018 Jul 26;174(3):716-729.e27. doi: 10.1016/j.cell.2018.05.061. Epub 2018 Jun 28.
PMID: 29961576
E-mail
raman@dartmouth.edu
Postal Address
Diwakar R. Pattabiraman PhD
Room 602, Rubin Bldg
Norris Cotton Cancer Center
Dartmouth-Hitchcok Medical Center
One Medical Center Drive
Lebanon NH 03756
HB 7936
Shipping Address
Raman Laboratory
6th floor Rubin
Norris Cotton Cancer Center
Borwell Loading Dock
Dartmouth-Hitchcock Medical Center
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