Landino Laboratory

Our lab is interested in how cells successfully divide into two daughter cells. This process ensures accurate segregation of the genome and cellular contents and is essential human development and disease. One outstanding question in the field is how the cell cortex is remodeled to support large-scale shape change during cytokinesis, the final stage of the cell cycle. It has recently been shown that the cell cortex is dynamically patterned prior to the onset of cytokinesis, and we are interested in defining the mechanisms of dynamic pattern formation at the cell cortex.

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Neighbor cells restrain furrowing during epithelial cytokinesis.
Landino J, Misterovich E, Chumki S, Miller AL
bioRxiv. 2023 Jun 8; pii: 2023.06.08.544077. doi: 10.1101/2023.06.08.544077. Epub 2023 Jun 8.
PMID: 37333405

A versatile cortical pattern-forming circuit based on Rho, F-actin, Ect2, and RGA-3/4.
Michaud A, Leda M, Swider ZT, Kim S, He J, Landino J, Valley JR, Huisken J, Goryachev AB, von Dassow G, Bement WM
J Cell Biol. 2022 Aug 1;221(8) doi: 10.1083/jcb.202203017. Epub 2022 Jun 16.
PMID: 35708547

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