Landino Laboratory

Our lab is interested in how cells successfully divide into two daughter cells. This process ensures accurate segregation of the genome and cellular contents and is essential human development and disease. One outstanding question in the field is how the cell cortex is remodeled to support large-scale shape change during cytokinesis, the final stage of the cell cycle. It has recently been shown that the cell cortex is dynamically patterned prior to the onset of cytokinesis, and we are interested in defining the mechanisms of dynamic pattern formation at the cell cortex.

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Neighbor cells restrain furrowing during Xenopus epithelial cytokinesis.
Landino J, Misterovich E, van den Goor L, Adhikary B, Chumki S, Davidson LA, Miller AL
Dev Cell. 2025 Aug 18;60(16):2139-2148.e6. doi: 10.1016/j.devcel.2025.03.010. Epub 2025 Apr 8.
PMID: 40203834

Membrane composition-dependent patterning of Rho and F-actin in an artificial cell cortex.
Schwarz GJ, Suber JR, Landino J
bioRxiv. 2025 Jul 31; pii: 2025.07.31.667950. doi: 10.1101/2025.07.31.667950. Epub 2025 Jul 31.
PMID: 40766503

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