A pluripotent developmental state confers a low fidelity of chromosome segregation.
Deng C, Ya A, Compton DA, Godek KM
Stem Cell Rep. 18:475–488 (2023).
Small changes in phospho-occupancy at the kinetochore–microtubule interface drive mitotic fidelity
Kucharski TJ, Hards R, Vandal SE, Abad MA, Jeyaprakash AA, Kaye E, al-Rawi A, Ly T, Godek KM, Gerber SA, Compton DA
J Cell Biol. 221(9):e202107107 (2022).
Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells.
Zhao Y, Carter R, Natarajan S, Varn FS, Compton DA, Gawad C, Cheng C, and Godek KM
BMC Medical Genomics. 12:79 (2019).
Quantitative methods to measure aneuploidy and chromosomal instability.
Godek KM and Compton DA
Methods Cell Biol. 144:15-32 (2018).
Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres. Shang WH, Hori T, Westhorpe FG, Godek KM, Toyoda A, Misu S, Monma N, Ikeo K, Carroll CW, Takami Y, Fujiyama A, Kimura H, Straight AF, Fukagawa T
Nat. Comm. 7:13465 (2016).
Dinaciclib induces anaphase catastrophe in lung cancer cells via inhibition of cyclin dependent kinases 1 and 2.
Danilov AV, Hu S, Orr B, Godek K, Mustachio LM, Sekula D, Liu X, Kawakami M, Johnson FM, Compton DA, Freemantle S, and Dmitrovsky E
Mol. Cancer Ther. 15:2758-66 (2016).
Chromosomal instability affects the tumorigenicity of glioblastoma tumor-initiating cells.
Godek KM, Venere M, Wu Q, Mills KD, Hickey WF, Rich JN, and Compton DA
Cancer Disc. 6:532-45 (2016).
Specific CP110 phosphorylation sites mediate anaphase catastrophe after CDK2 inhibition: evidence for cooperation with USP33 knockdown.
Hu S, Lu Y, Orr B, Godek K, Mustachio LM, Kawakami M, Sekula D, Compton DA, Freemantle S, and Dmitrovsky E
Mol. Cancer Ther. 14:2576-85 (2015).
Aneuploidy.
Orr B, Godek KM, and Compton D
Curr. Bio. 25:R538-42 (2015).
CDK2 inhibition causes anaphase catastrophe in lung cancer through the centrosomal protein CP110.
Hu S, Danilov AV, Godek K, Orr B, Tafe LJ, Rodriguez-Canales J, Behrens C, Mino B, Moran CA, Memoli, VA, Mustachio LM, Galimberti F, Ravi S, DeCastro A, Lu Y, Sekula D, Andrew AS, Wistuba II, Freemantle S, Compton DA, Dmitrovsky, E
Cancer Res. 75:2029-38 (2015).
Regulation of kinetochore microtubule attachments through homeostatic control during mitosis.
Godek KM, Kabeche L, and Compton DA
Nat. Rev. Mol. Cell Biol. 16:57-64 (2015).
Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N.
Carroll CW, Silva MC, Godek KM, Jansen LE, and Straight AF
Nat. Cell Bio. 11:896-902 (2009).