1. Novel Transplant Therapeutics—Targeted Immunosuppressants and Cellular Therapies
Our laboratory is evaluating novel immunotherapies designed to promote long-term graft tolerance while minimizing toxicity. We utilize murine models to test new costimulation blockade agents and cellular adoptive transfer strategies. This work aims to generate more precise, durable, and safe immunosuppressive regimens for clinical application.
2. Artificial Intelligence for Predictive Modeling of Transplant Outcomes
Building on our expertise with large clinical datasets and with support from computational collaborators, our ongoing work incorporates artificial intelligence and modern machine learning approaches to advance predictive modeling in transplantation. We aim to develop machine learning algorithms to enhance personalized risk stratification for transplant donors and recipients.
3. Clinical Outcomes Research in Transplantation
We lead and participate in multi-institutional cohort studies analyzing national registry and clinical databases to define risk factors, long-term outcomes, and best practices in transplantation. Our research has addressed diverse topics such as liver transplantation for inflammatory bowel disease, surgical management in cancer recipients, and perioperative cardiac events in transplant recipients. These studies help define evidence-based guidelines for patient selection, procedural approaches, and post-transplant care.