Recent Publications
Morris, N.J., Ducret, A., Aebersold, R., Ross, S.A., Keller, S.R., and Lienhard, G.E. Membrane Amine Oxidase. Cloning and Identification as a Major Protein in the Adipocyte Plasma Membrane. J. Biol. Chem. 272, 9388-9392 (1997)
Herbst, J.J., Ross, S.A., Scott, H.M., Bobin, S.A., Morris, N.J., Lienhard, G.E., and Keller, S.R. Insulin Stimulates Cell Surface Aminopeptidase Activity Toward Vasopressin in Adipocytes. Am. J. Physiol. 272, E600-606(1997)
Lavan, B.E., Lane, W.S., and Lienhard, G.E. The 60-kDa Phosphotyrosine Protein in Insulin-treated Adipocytes is a New Member of the Insulin Receptor Substrate Family. J. Biol. Chem. 272, 11439-11443(1997)
Lavan, B.E., Fantin, V.R., Chang, E.T., Lane, W. S., Keller, S.R., and Lienhard, G.E. A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells is a New Member of the Insulin Receptor Substrate Family. J. Biol. Chem. 272, 21403-21407 (1997)
Ross, S.A., Herbst, J.J., Keller, S.R., and Lienhard, G.E. Trafficking Kinetics of the Insulin-regulated Aminopeptidase in 3T3-L1 Adipocytes. Biochem. Biophys. Res. Commun. 239, 247-251(1997)
Morris, N. J., Ross, S.A., Lane, W.S., Moestrup, S.K., Petersen, C.M., Keller, S.R., and Lienhard, G.E. Sortilin is the Major 110 kDa Protein in GLUT4 Vesicles from Adipocytes. J. Biol. Chem. 273, 3582-3587 (1998)
Ross, S.A., Keller, S.R., and Lienhard, G.E. Increased Intracellular Sequestration of the Insulin-regulated Aminopeptidase upon Differentiation of 3T3-L1 Cells. Biochem. J. 330, 1003-1008 (1998)
Fantin, V.R., Sparling, J.D., Slot, J.W., Keller, S.R., Lienhard, G.E., and Lavan, B.E. Characterization of Insulin Receptor Substrate 4 in Human Embryonic Kidney Cells. J. Biol. Chem. 273, 10726-10732 (1998)
Ross, S.A., Lienhard, G.E., and Lavan, B.E. Association of Insulin Receptor Substrate 3 with SH2 Domain-containing Proteins in Rat Adipocytes. Biochem. Biophys. Res. Commun. 247, 487-492 (1998)
Fantin, V.R., Lavan, B.E., Wang, Q., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Keller, S.R., and Lienhard, G.E. Cloning, Tissue Expression, and Chromosomal Location of the Mouse Insulin Receptor Substrate 4 Gene. Endocrinology 140, 1329-1337 (1999)
Liu, S.C.H., Wang, Q., Lienhard, G.E., and Keller, S.R. Insulin Receptor Substrate 3 is Not Essential for Growth or Glucose Homeostasis. J. Biol. Chem. 274, 18093-18099 (1999)
Morris, N.J., Ross, S.A., Neveu, J.M., Lane, W.S., and Lienhard, G.E. Cloning and Preliminary Characterization of a 121kDa Protein with Multiple Predicted C2 Domains. Biochim. Biophys. Acta 1431, 525-530 (1999)
Morris, N.J., Ross, S.A., Neveu, J.M., Lane, W. S., and Lienhard, G.E. Cloning and Characterization of a 22 kDa Protein from Rat Adipocytes: a New Member of the Reticulon Family. Biochim. Biophys. Acta 1450, 68-76 (1999)
Fantin, V.R., Keller, S.A., Lienhard, G.E., and Wang, L-M. Insulin Receptor Substrate 4 Supports Insulin and Interleukin 4-Stimulated Proliferation of Hematopoietic Cells. Biochem. Biophys. Res. Commun. 260, 718-723 (1999)
Fantin, V.R., Wang, Q., Lienhard, G. E., and Keller, S.R. Mice Lacking Insulin Receptor Substrate 4 Exhibit Mild Defects in Growth, Reproduction, and Glucose Homeostasis. Am. J. Physiol. , 278, E127-E133 (2000)
Liu, S.C.H., Lane, W.S., and Lienhard, G.E. Cloning and Preliminary Characterization of a 105 kDa Protein with an N-terminal Kinase-like Domain. Biochim. Biophys. Acta, 1517, 148-152 (2000)
Laustsen, P.G., Lane, W.S., Bennett, V., and Lienhard, G.E. Association of Protein Kinase Cl with Adducin in 3T3-L1 Adipocytes. Biochim. Biophys. Acta, 1539, 163-172 (2001)
Sano, H., Liu, S.C.H., Lane, W.S., Piletz, J.E., and Lienhard, G.E. Insulin Receptor Substrate 4 Associates with the Protein IRAS, J. Biol. Chem. 277, 19439-19447 (2002)
Kane, S., Sano, H., Liu, S.C.H., Asara, J.M., Lane, W.S., Garner, C.W. , and Lienhard, G.E. A Method to Identify Serine Kinase Substrates. Akt Phosphorylates a Novel Adipocyte Protein with a Rab GTPase-activating Protein (GAP) Domain. J. Biol. Chem. 277, 22115-22118 (2002)
Bjornholm, M., He, A.R., Attersand, A., Lake, S., Liu, S.C.H., Lienhard, G.E., Taylor, S., Arner, P., and Zierath, J.R. Absence of Functional Insulin Receptor Substrate-3 (IRS-3) Gene in Humans. Diabetologia 45, 1697-1702 (2002)
Laustsen, P.G., Michael, M.D., Crute, B.E., Cohen, S.E., Ueki, K., Kulkarni, R.N., Keller, S.R., Lienhard, G.E., and Kahn, C.R. Lipoatrophic Diabetes in Irs1-/-/Irs3-/- Double Knockout Mice. Genes Dev. 16, 3213-3222 (2002)
Miinea, C.P., and Lienhard, G.E. Estimating the Stoichiometry of Site-specific Protein Phosphorylation with Phosphopeptide-specific Antibodies. BioTechniques, 34, 828-831 (2003)
Terauchi, Y., Matsui, J., Suzuki, R., Kubota, N., Komeda, K., Aizawa, S., Eto, K., Kimura, S., Tobe, K., Lienhard, G.E., and Kadowaki, T. Impact of Genetic Background and Ablation of IRS-3 on IRS-2 Knockout Mice. J. Biol. Chem., 278, 14284-14290 (2003)
Sano, H., Kane, S., Sano, E., Miinea, C.P., Asara, J.M., Lane, W.S., Garner, C.W., and Lienhard, G.E. Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation. J. Biol. Chem., 278, 14599-14602 (2003)
Gridley, S., Lane, W.S., Garner, C.W., and Lienhard, G.E. Novel Insulin-elicited Phosphoproteins in Adipocytes. Cellular Signalling 17, 59-66 (2005)
Sano, H., Kane, S., Sano, E., and Lienhard, G.E. Synip Phosphorylation Does Not Regulate Insulin-stimulated GLUT4 Translocation. Biochem. Biophys. Res. Commun. 332, 880-884 (2005)
Kane, S., and Lienhard, G.E. Calmodulin Binds to the Rab GTPase Activating Protein Required for Insulin-stimulated GLUT4 Translocation. Biochem. Biophys. Res. Commun. 335, 175-180 (2005)
Miinea, C.P., Sano, H., Kane, S., Sano, E., Fukuda, M., Peranen, J., Lane, W.S., and Lienhard, G.E. AS160, the Akt Substrate Regulating GLUT4 Translocation, Has a Functional Rab GTPase-activating Protein Domain. Biochem. J. 391, 87-93 (2005)
Equez, L., Lee, A., Chavez, J.A., Miinea, C.P., Kane, S., Lienhard, G.E., and McGraw, T.E. Full Intracellular Retention of GLUT4 Requires AS160 Rab GTPase Activating Protein. Cell Metabolism 2, 263-272 (2005)
Gridley, S., Chavez, J.A., Lane, W.S., and Lienhard, G.E. Adipocytes Contain a Novel Complex Similar to the Tuberous Sclerosis Complex. Cellular Signaling 18, 1626-1632(2006)
Chavez, J.A., Gridley, S., Sano, H., Lane, W.S., and Lienhard, G.E. The 47 kDa Akt Substrate Associates with Phosphodiesterase 3B and Regulates its Level in 3T3-L1 Adipocytes. Biochem. Biophys. Res. Commun. 342, 1218-1222 (2006)
Schmelzle, K., Kane, S., Gridley, S., Lienhard, G.E. and White, F.M. Temporal Dynamics of Tyrosine Phosphorylation in Insulin Signaling. Diabetes 55 , 2171-2179 (2006)
Roach, W.G., Chavez, J.A., Miinea, C.P. and Lienhard, G.E. Substrate Specificity and Effect on GLUT4 Translocation of the Rab GTPase Activating Protein Tbc1d1. Biochem. J. 403, 353-358 (2007)
Sano, H., Equez, L., Teruel, M.N., Fukuda, M., Chuang, T.D., Chavez, J.A., Lienhard, G.E., and McGraw, T.E. Rab10, a Target of the AS160 RabGAP, Is Required for Insulin-stimulated Translocation of GLUT4 to the Adipocyte Plasma Membrane. Cell Metabolism 5, 293-303 (2007)
Sano, H., Roach, W.G., Peck, G.R., Fukuda, M., and Lienhard, G.E. Rab10 in Insulin-stimulated GLUT4 Translocation. Biochem. J. 411, 89-95 (2008)
Chavez, J.A., Roach, W.G., Keller, S.R., Lane, W.S., and Lienhard, G.E. Inhibition of GLUT4 Translocation by Tbc1d1, a Rab GTPase Activating Protein Abundant in Skeletal Muscle, Is Partially Relieved by AMPK Activation. J. Biol. Chem. 283, 9187-9195 (2008)
Lienhard, G.E. Non-functional Phosphorylations? Trends Biochem. Sci. 33, 351-353 (2008)
Lyons, P.D., Peck, G.R., Kettenbach, A.N., Gerber, S.A., Roudaia, L., and Lienhard, G.E. Insulin Stimulates the Phosphorylation of the Exocyst Protein Sec8 in Adipocytes. Biosci. Rep. 29, 229-235 (2009)
Peck, G.R., Chavez, J.A., Roach, W.G., Budnik, B.A., Lane, W.S., Karlsson, H.K.R., Zierath, J.R., and Lienhard, G.E. Insulin-stimulated Phosphorylation of the Rab GTPase Activating Protein TBC1D1 Regulates GLUT4 Translocation. J. Biol. Chem. 284, 30016-30023 (2009)