The Lau Laboratory investigates pathways that can be modulated to prevent malignant transformation or treat cancers that arise in patients with cancer predisposition syndromes. One focus of the lab is to study premalignant and malignant tissue from patients with DNA damage repair defects (e.g. Fanconi Anemia) and determine whether the mutations in these patients result in new protein coding sequences, called neoantigens, which can be recognized as "foreign" by the patient's immune system. Certain neoantigen profiles can predict response to therapies that work by unleashing the patient's own immune system to attack their tumor (immunotherapies). We are using gene editing as well as mouse models to study these cancer predisposition syndromes and how their tumors respond to immunotherapies.
Lau Laboratory
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Publications
- Shiyu Wang, Natalia H Zbib, Alyza Skaist, Jiang Gui, Rafael Madero-Marroquin, Federico De Marchi, Lukasz P Gondek, William Matsui, Bonnie W Lau
Whole exome sequencing identifies functional classes of gene mutations associated with bone marrow failure in pediatric Fanconi Anemia patients. Eur J Haematol. 2021 May 7. doi: 10.1111/ejh.13645. (view details in PubMed) - Kennedy AL, Myers KC, Bowman J, Gibson CJ, Camarda ND, Furutani E, Muscato GM, Klein RH, Ballotti K, Liu S, Harris CE, Galvin A, Malsch M, Dale D, Gansner JM, Nakano TA, Bertuch A, Vlachos A, Lipton JM, Castillo P, Connelly J, Churpek J, Edwards JR, Hijiy Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome. Nat Commun. 2021 Feb 26;12(1):1334 (view details in PubMed)
- Nakano TA, Lau BW, Dickerson KE, Wlodarski M, Pollard J, Shimamura A, Hofmann I, Sasa G, Elghetany T, Cada M, Dror Y, Ding H, Allen SW, Hanna R, Campbell K, Olson TS Diagnosis and treatment of pediatric myelodysplastic syndromes: A survey of the North American Pediatric Aplastic Anemia Consortium. Pediatr Blood Cancer. 2020 Oct;67(10):e28652 (view details in PubMed)
- Berk J, Hall D, Stroh I, Armstrong C, Mishra K, Pecker LH, Lau BW A Child With Pancytopenia and Optic Disc Swelling. Pediatrics. 2019 Nov;144(5) (view details in PubMed)
- Lau BW, Huh K, Madero-Marroquin R, De Marchi F, Lim Y, Wang Q, Lobo F, Marchionni L, Smith DB, DeZern A, Levis MJ, Aplan PD, Matsui W, Gondek LP Hedgehog/GLI1 activation leads to leukemic transformation of myelodysplastic syndrome in vivo and GLI1 inhibition results in antitumor activity. Oncogene. 2019 Jan;38(5):687-698 (view details in PubMed)
Contact Us
Electronic Mail
Bonnie.W.Lau@Dartmouth.edu
Dr. Bonnie W. Lau
Assistant Professor of Pediatrics
Pediatric Hematologist Oncologist
Norris Cotton Cancer Center (Principal Investigator)
Postal Address
Pediatrics
Dartmouth Hitchcock Medical Center
One Medical Center Drive
Lebanon NH 03756
Telephone
Office: (603)650-6475
Phone: (603)653-9964
Fax
(603)650-0591