COVID-19 Information

Selected Publications

Luminescence complementation technology for the identification of MYC:TRRAP inhibitors.
Feris EJ, Hinds JW, Cole MD
Oncotarget. 2021 Oct 12;12(21):2147-2157. doi: 10.18632/oncotarget.28078. Epub 2021 Oct 12.
PMID: 34676047

Genetic Variation and Recurrent Haplotypes on Chromosome 6q23-25 Risk Locus in Familial Lung Cancer.
Musolf AM, Simpson CL, Moiz BA, Pikielny CW, Middlebrooks CD, Mandal D, de Andrade M, Cole MD, Gaba C, Yang P, You M, Li Y, Kupert EY, Anderson MW, Schwartz AG, Pinney SM, Amos CI, Bailey-Wilson JE
Cancer Res. 2021 Jun 15;81(12):3162-3173. doi: 10.1158/0008-5472.CAN-20-3196. Epub 2021 Apr 14.
PMID: 33853833

Formation of a structurally-stable conformation by the intrinsically disordered MYC:TRRAP complex.
Feris EJ, Hinds JW, Cole MD
PLoS One. 2019;14(12):e0225784. doi: 10.1371/journal.pone.0225784. Epub 2019 Dec 2.
PMID: 31790487

SEC24A identified as an essential mediator of thapsigargin-induced cell death in a genome-wide CRISPR/Cas9 screen.
Chidawanyika T, Sergison E, Cole M, Mark K, Supattapone S
Cell Death Discov. 2018;4:115. doi: 10.1038/s41420-018-0135-5. Epub 2018 Dec 18.
PMID: 30588337

Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples.
Gorlov IP, Pikielny CW, Frost HR, Her SC, Cole MD, Strohbehn SD, Wallace-Bradley D, Kimmel M, Gorlova OY, Amos CI
BMC Bioinformatics. 2018 Nov 19;19(1):430. doi: 10.1186/s12859-018-2455-0. Epub 2018 Nov 19.
PMID: 30453881

Inhibition of the Proteasome β2 Site Sensitizes Triple-Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation.
Weyburne ES, Wilkins OM, Sha Z, Williams DA, Pletnev AA, de Bruin G, Overkleeft HS, Goldberg AL, Cole MD, Kisselev AF
Cell Chem Biol. 2017 Feb 16;24(2):218-230. doi: 10.1016/j.chembiol.2016.12.016. Epub 2017 Jan 26.
PMID: 28132893

HS3ST1 genotype regulates antithrombin's inflammomodulatory tone and associates with atherosclerosis.
Smits NC, Kobayashi T, Srivastava PK, Skopelja S, Ivy JA, Elwood DJ, Stan RV, Tsongalis GJ, Sellke FW, Gross PL, Cole MD, DeVries JT, Kaplan AV, Robb JF, Williams SM, Shworak NW
Matrix Biol. 2017 Nov;63:69-90. doi: 10.1016/j.matbio.2017.01.003. Epub 2017 Jan 23.
PMID: 28126521

MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase.
Posternak V, Ung MH, Cheng C, Cole MD
Mol Cancer Res. 2017 Feb;15(2):213-224. doi: 10.1158/1541-7786.MCR-16-0247. Epub 2016 Nov 29.
PMID: 27899423

Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk.
Pattison JM, Posternak V, Cole MD
Mol Cancer Res. 2016 Nov;14(11):1078-1086. Epub 2016 Aug 11.
PMID: 27514407

An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression.
Wyszynski A, Hong CC, Lam K, Michailidou K, Lytle C, Yao S, Zhang Y, Bolla MK, Wang Q, Dennis J, Hopper JL, Southey MC, Schmidt MK, Broeks A, Muir K, Lophatananon A, Fasching PA, Beckmann MW, Peto J, Dos-Santos-Silva I, Sawyer EJ, Tomlinson I, Burwinkel B, Marme F, Guenel P, Truong T, Bojesen SE, Nordestgaard BG, Gonzalez-Neira A, Benitez J, Neuhausen SL, Brenner H, Dieffenbach AK, Meindl A, Schmutzler RK, Brauch H, GENICA Network., Nevanlinna H, Khan S, Matsuo K, Ito H, Dork T, Bogdanova NV, Lindblom A, Margolin S, Mannermaa A, Kosma VM, kConFab Investigators., Australian Ovarian Cancer Study Group., Wu AH, Van Den Berg D, Lambrechts D, Wildiers H, Chang-Claude J, Rudolph A, Radice P, Peterlongo P, Couch FJ, Olson JE, Giles GG, Milne RL, Haiman CA, Henderson BE, Dumont M, Teo SH, Wong TY, Kristensen V, Zheng W, Long J, Winqvist R, Pylkas K, Andrulis IL, Knight JA, Devilee P, Seynaeve C, Garcia-Closas M, Figueroa J, Klevebring D, Czene K, Hooning MJ, van den Ouweland AM, Darabi H, Shu XO, Gao YT, Cox A, Blot W, Signorello LB, Shah M, Kang D, Choi JY, Hartman M, Miao H, Hamann U, Jakubowska A, Lubinski J, Sangrajrang S, McKay J, Toland AE, Yannoukakos D, Shen CY, Wu PE, Swerdlow A, Orr N, Simard J, Pharoah PD, Dunning AM, Chenevix-Trench G, Hall P, Bandera E, Amos C, Ambrosone C, Easton DF, Cole MD
Hum Mol Genet. 2016 Sep 1;25(17):3863-3876. doi: 10.1093/hmg/ddw223. Epub 2016 Jul 11.
PMID: 27402876

Cowling VH, Turner SA, Cole MD
Burkitt's lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate Nol5a/Nop56 in oncogenesis
Oncogene 2013 Sep 9
PMID: 24013231