Selected Publications
S146L in MYC is a context-dependent activating substitution in cancer development.
Hinds JW, Feris EJ, Wilkins OM, Deary LT, Wang X, Cole MD
PLoS One. 2022;17(8):e0272771. doi: 10.1371/journal.pone.0272771. Epub 2022 Aug 26.
PMID: 36018850
Luminescence complementation technology for the identification of MYC:TRRAP inhibitors.
Feris EJ, Hinds JW, Cole MD
Oncotarget. 2021 Oct 12;12(21):2147-2157. doi: 10.18632/oncotarget.28078. Epub 2021 Oct 12.
PMID: 34676047
Genetic Variation and Recurrent Haplotypes on Chromosome 6q23-25 Risk Locus in Familial Lung Cancer.
Musolf AM, Simpson CL, Moiz BA, Pikielny CW, Middlebrooks CD, Mandal D, de Andrade M, Cole MD, Gaba C, Yang P, You M, Li Y, Kupert EY, Anderson MW, Schwartz AG, Pinney SM, Amos CI, Bailey-Wilson JE
Cancer Res. 2021 Jun 15;81(12):3162-3173. doi: 10.1158/0008-5472.CAN-20-3196. Epub 2021 Apr 14.
PMID: 33853833
Formation of a structurally-stable conformation by the intrinsically disordered MYC:TRRAP complex.
Feris EJ, Hinds JW, Cole MD
PLoS One. 2019;14(12):e0225784. doi: 10.1371/journal.pone.0225784. Epub 2019 Dec 2.
PMID: 31790487
SEC24A identified as an essential mediator of thapsigargin-induced cell death in a genome-wide CRISPR/Cas9 screen.
Chidawanyika T, Sergison E, Cole M, Mark K, Supattapone S
Cell Death Discov. 2018;4:115. doi: 10.1038/s41420-018-0135-5. Epub 2018 Dec 18.
PMID: 30588337
Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples.
Gorlov IP, Pikielny CW, Frost HR, Her SC, Cole MD, Strohbehn SD, Wallace-Bradley D, Kimmel M, Gorlova OY, Amos CI
BMC Bioinformatics. 2018 Nov 19;19(1):430. doi: 10.1186/s12859-018-2455-0. Epub 2018 Nov 19.
PMID: 30453881
Inhibition of the Proteasome β2 Site Sensitizes Triple-Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation.
Weyburne ES, Wilkins OM, Sha Z, Williams DA, Pletnev AA, de Bruin G, Overkleeft HS, Goldberg AL, Cole MD, Kisselev AF
Cell Chem Biol. 2017 Feb 16;24(2):218-230. doi: 10.1016/j.chembiol.2016.12.016. Epub 2017 Jan 26.
PMID: 28132893
HS3ST1 genotype regulates antithrombin's inflammomodulatory tone and associates with atherosclerosis.
Smits NC, Kobayashi T, Srivastava PK, Skopelja S, Ivy JA, Elwood DJ, Stan RV, Tsongalis GJ, Sellke FW, Gross PL, Cole MD, DeVries JT, Kaplan AV, Robb JF, Williams SM, Shworak NW
Matrix Biol. 2017 Nov;63:69-90. doi: 10.1016/j.matbio.2017.01.003. Epub 2017 Jan 23.
PMID: 28126521
MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase.
Posternak V, Ung MH, Cheng C, Cole MD
Mol Cancer Res. 2017 Feb;15(2):213-224. doi: 10.1158/1541-7786.MCR-16-0247. Epub 2016 Nov 29.
PMID: 27899423
Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk.
Pattison JM, Posternak V, Cole MD
Mol Cancer Res. 2016 Nov;14(11):1078-1086. Epub 2016 Aug 11.
PMID: 27514407
Cowling VH, Turner SA, Cole MD
Burkitt's lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate Nol5a/Nop56 in oncogenesis
Oncogene 2013 Sep 9
PMID: 24013231