Selected Publications

Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples.
Gorlov IP, Pikielny CW, Frost HR, Her SC, Cole MD, Strohbehn SD, Wallace-Bradley D, Kimmel M, Gorlova OY, Amos CI
BMC Bioinformatics. 2018 Nov 19;19(1):430. doi: 10.1186/s12859-018-2455-0. Epub 2018 Nov 19.
PMID: 30453881

Inhibition of the Proteasome β2 Site Sensitizes Triple-Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation.
Weyburne ES, Wilkins OM, Sha Z, Williams DA, Pletnev AA, de Bruin G, Overkleeft HS, Goldberg AL, Cole MD, Kisselev AF
Cell Chem Biol. 2017 Feb 16;24(2):218-230. doi: 10.1016/j.chembiol.2016.12.016. Epub 2017 Jan 26.
PMID: 28132893

HS3ST1 genotype regulates antithrombin's inflammomodulatory tone and associates with atherosclerosis.
Smits NC, Kobayashi T, Srivastava PK, Skopelja S, Ivy JA, Elwood DJ, Stan RV, Tsongalis GJ, Sellke FW, Gross PL, Cole MD, DeVries JT, Kaplan AV, Robb JF, Williams SM, Shworak NW
Matrix Biol. 2017 Nov;63:69-90. doi: 10.1016/j.matbio.2017.01.003. Epub 2017 Jan 23.
PMID: 28126521

MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase.
Posternak V, Ung MH, Cheng C, Cole MD
Mol Cancer Res. 2017 Feb;15(2):213-224. doi: 10.1158/1541-7786.MCR-16-0247. Epub 2016 Nov 29.
PMID: 27899423

Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk.
Pattison JM, Posternak V, Cole MD
Mol Cancer Res. 2016 Nov;14(11):1078-1086. Epub 2016 Aug 11.
PMID: 27514407

An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression.
Wyszynski A, Hong CC, Lam K, Michailidou K, Lytle C, Yao S, Zhang Y, Bolla MK, Wang Q, Dennis J, Hopper JL, Southey MC, Schmidt MK, Broeks A, Muir K, Lophatananon A, Fasching PA, Beckmann MW, Peto J, Dos-Santos-Silva I, Sawyer EJ, Tomlinson I, Burwinkel B, Marme F, Guenel P, Truong T, Bojesen SE, Nordestgaard BG, Gonzalez-Neira A, Benitez J, Neuhausen SL, Brenner H, Dieffenbach AK, Meindl A, Schmutzler RK, Brauch H, GENICA Network., Nevanlinna H, Khan S, Matsuo K, Ito H, Dork T, Bogdanova NV, Lindblom A, Margolin S, Mannermaa A, Kosma VM, kConFab Investigators., Australian Ovarian Cancer Study Group., Wu AH, Van Den Berg D, Lambrechts D, Wildiers H, Chang-Claude J, Rudolph A, Radice P, Peterlongo P, Couch FJ, Olson JE, Giles GG, Milne RL, Haiman CA, Henderson BE, Dumont M, Teo SH, Wong TY, Kristensen V, Zheng W, Long J, Winqvist R, Pylkas K, Andrulis IL, Knight JA, Devilee P, Seynaeve C, Garcia-Closas M, Figueroa J, Klevebring D, Czene K, Hooning MJ, van den Ouweland AM, Darabi H, Shu XO, Gao YT, Cox A, Blot W, Signorello LB, Shah M, Kang D, Choi JY, Hartman M, Miao H, Hamann U, Jakubowska A, Lubinski J, Sangrajrang S, McKay J, Toland AE, Yannoukakos D, Shen CY, Wu PE, Swerdlow A, Orr N, Simard J, Pharoah PD, Dunning AM, Chenevix-Trench G, Hall P, Bandera E, Amos C, Ambrosone C, Easton DF, Cole MD
Hum Mol Genet. 2016 Sep 1;25(17):3863-3876. doi: 10.1093/hmg/ddw223. Epub 2016 Jul 11.
PMID: 27402876

Strategically targeting MYC in cancer.
Posternak V, Cole MD
F1000Res. 2016;5 pii: F1000 Faculty Rev-408. doi: 10.12688/f1000research.7879.1. Epub 2016 Mar 29.
PMID: 27081479

Retroviruses hijack chromatin loops to drive oncogene expression and highlight the chromatin architecture around proto-oncogenic loci.
Pattison JM, Wright JB, Cole MD
PLoS One. 2015;10(3):e0120256. doi: 10.1371/journal.pone.0120256. Epub 2015 Mar 23.
PMID: 25799187

MYC association with cancer risk and a new model of MYC-mediated repression.
Cole MD
Cold Spring Harb Perspect Med. 2014 Jul 1;4(7):a014316. doi: 10.1101/cshperspect.a014316. Epub 2014 Jul 1.
PMID: 24985129

Functional genomics annotation of a statistical epistasis network associated with bladder cancer susceptibility.
Hu T, Pan Q, Andrew AS, Langer JM, Cole MD, Tomlinson CR, Karagas MR, Moore JH
BioData Min. 2014 Apr 11;7(1):5. doi: 10.1186/1756-0381-7-5. Epub 2014 Apr 11.
PMID: 24725556

Cowling VH, Turner SA, Cole MD
Burkitt's lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate Nol5a/Nop56 in oncogenesis
Oncogene 2013 Sep 9
PMID: 24013231