{"id":25,"date":"2018-02-12T15:50:04","date_gmt":"2018-02-12T20:50:04","guid":{"rendered":"http:\/\/sites.dartmouth.edu\/schultz\/?page_id=25"},"modified":"2025-05-19T15:51:03","modified_gmt":"2025-05-19T15:51:03","slug":"papers","status":"publish","type":"page","link":"https:\/\/geiselmed.dartmouth.edu\/schultz\/papers\/","title":{"rendered":"Papers"},"content":{"rendered":"
\n
\n
\n
\n
\n
\n

Dynamics of antibiotic responses:<\/strong><\/p>\n

Stevanovic, M<\/strong>; Carvalho, JPT<\/strong>; Bittihn, P; Schultz, D<\/strong>. (2024) Dynamical model of antibiotic responses linking expression of resistance to metabolism explains emergence of heterogeneity during drug exposures. Phys Biol<\/em>\u00a021<\/strong>, 036002.<\/a><\/p>\n

Schultz, D<\/strong>; Stevanovic, M<\/strong>; Tsimring, L. (2022) Optimal transcriptional regulation of dynamic bacterial responses to sudden rug exposures. Biophys J<\/em>\u00a0121<\/strong>, 4137-4152.<\/a><\/p>\n

Stevanovic, M<\/strong>; Bouk\u00e9k\u00e9-Lesplulier, T; Hupe, L; Hasty, J; Bittihn, P; Schultz, D<\/strong>.(2022) Nutrient gradients mediate complex colony-level antibiotic responses in structured microbial populations. Front Microbiol<\/em> 13<\/strong>, 740259.<\/a><\/p>\n

Wehrens, M; Ershov, D; Rozendaal, R; Walker, N;\u00a0Schultz, D<\/strong> ; Kishony, R; Levin, PA; Tans SJ (2018) Size laws and division ring dynamics in filamentous Escherichia coli<\/em> cells. Curr Biol<\/em>\u00a028<\/strong>, 972-979.<\/a><\/p>\n

Schultz, D<\/strong> ; Palmer, AC; Kishony, R (2017) Regulatory dynamics determine cell fate following abrupt antibiotic exposure. Cell Systems<\/em>\u00a05<\/strong>, 509-517.<\/a><\/p>\n

\n
\n
\n
\n
\n
\n

Microbial evolution:<\/strong><\/p>\n

Crow, JC<\/strong>; Geng<\/strong>, H; <\/strong>Schultz D<\/strong>. (2025) Drug delivery dynamics dictate evolution of bacterial
\nantibiotic responses. ISME J<\/em>\u00a019<\/strong>, wraf082.<\/a><\/p>\n

Schultz, D<\/strong>. (2023) mSphere of Influence: Learning biology from the radio. mSphere <\/em>8<\/strong>, e00026-23.<\/a><\/p>\n

Mould, DL; Stevanovic, M<\/strong>; Ashare, A; Schultz, D<\/strong>; Hogan, DA. (2022) Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa<\/em> variant. eLife<\/em> 11<\/strong>, e76555.<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n

Kaminski, S; [...]; Schultz, D<\/strong> et al. (2019) Evolthon: a community endeavor to evolve lab evolution. PLOS Biol<\/em>\u00a017<\/strong>, e3000182.<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n

Schultz, D<\/strong> ; Kishony, R (2013) Optimization and control in bacterial Lag phase. BMC Biology<\/em>, 11<\/strong>, 120.<\/a><\/p>\n

Microbial communities:<\/strong><\/p>\n

Sudo, K; [...] Dawson, PA; Schultz, D<\/strong>; Sundrud, MS. (2024) Quantifying forms and functions of intestinal bile acid pools in mice. CMGH<\/em> 18<\/strong>, 101392.<\/a><\/p>\n

Holt, JD; Schultz, D<\/strong>; Nadell, CD. (2024) Dispersal of a dominant competitor can drive multi-species coexistence in biofilms. Curr Biol<\/em> 34<\/strong>, 1-14. <\/a><\/p>\n

Robitaille, S; Simmons EL; Verster, AJ; McClure, EA; Royce, DB; Trus, E; Swartz, K; Schultz, D<\/strong>; Nadell, CD; Ross, BD. (2023) Community composition and the environment modulate the population dynamics of type VI secretion in human gut bacteria. Nat Ecol Evo<\/em>\u00a07<\/strong>, 2092\u20132107. <\/a><\/p>\n

Jean-Pierre, F; Hampton, TH; Schultz, D<\/strong>; Hogan, DA; Groleau, MC; D\u00e9ziel, E; O\u2019Toole, GA. (2023) Community composition shapes microbial-specific phenotypes in a cystic fibrosis polymicrobial model system. eLife<\/em> 12, <\/strong>e81604.<\/a><\/p>\n

Webster, SS; Matheli\u00e9-Guinlet, M; Verissimo<\/span>, AF; Schultz<\/span>, D<\/strong>; Viljoen, A;<\/span>\u00a0Lee, CK; <\/span>Schmidt, WC;<\/span>\u00a0Wong, GCL;<\/span>\u00a0Dufr\u00eane, YF;<\/span>\u00a0O\u2019Toole, GA<\/span>. (2022) Force-induced changes of PilY1 drive surface sensing by Pseudomonas aeruginosa<\/em>. MBio<\/em> 13<\/strong>, e0375421.<\/a><\/p>\n

O\u2019Toole, GA; [...]; Schultz, D<\/strong> et al. (2021) Model systems to study the chronic, polymicrobial infections in cystic fibrosis: Current approaches and exploring future directions. mBio<\/em> 12<\/strong>, e0176321.<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

Phenotypic heterogeneity in microbial colonies:<\/strong><\/p>\n

Kowalski, CH; Morelli, KA, Schultz, D<\/strong>; Nadell, CD; Cramer, RA. (2020) Fungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance. Proc Natl Acad Sci USA<\/em>\u00a0117<\/strong>, 22473\u201322483.<\/a><\/p>\n

Schultz, D <\/strong>(2016) Coordination of cell decisions and promotion of phenotypic diversity in B. subtilis<\/em> via pulsed behavior of the phosphorelay. BioEssays<\/em>\u00a038<\/strong>, 440-5.<\/a><\/p>\n

Ben Jacob, E; Lu, MY; Schultz, D<\/strong> ; Onuchic, JN (2014) The physics of bacterial decision making. Front Cell Infect Microbiol<\/em> \u00a04<\/strong>, 154.<\/a><\/p>\n

Schultz, D<\/strong> ; Lu, MY; Stavropoulos, T; Onuchic, JN; Ben Jacob, E (2013) Turning oscillations into opportunities: lessons from a bacterial decision gate. Scientific Reports<\/em>\u00a03<\/strong>, 1668.<\/a><\/p>\n

Schultz, D<\/strong> ; Onuchic, JN; Ben Jacob, E (2012) Turning death into creative force during biofilm engineering. Proc Natl Acad Sci USA<\/em>\u00a0109<\/strong>, 18633-18634.<\/a><\/p>\n

Ben Jacob, E; Schultz, D<\/strong> (2010) Bacteria determine fate by playing dice with controlled odds. Proc Natl Acad Sci USA<\/em>\u00a0107<\/strong>, 13197-13198.<\/a><\/p>\n

Schultz, D<\/strong> ; Wolynes, PG; Ben Jacob, E; Onuchic, JN (2009) Deciding fate in adverse times: Sporulation and competence in Bacillus subtilis<\/em>. Proc Natl Acad Sci USA<\/em>\u00a0106<\/strong>, 21027-21034.<\/a><\/p>\n

Stochasticity in gene networks:<\/strong><\/p>\n

Schultz, D<\/strong> ; Walczak, AM; Onuchic, JN; Wolynes, PG (2008) Extinction and resurrection in gene networks. Proc Natl Acad Sci USA<\/em>\u00a0105<\/strong>, 19165-19170.<\/a><\/p>\n

Schultz, D<\/strong> ; Ben Jacob, E; Onuchic, JN; Wolynes, PG (2007) Molecular level stochastic model for competence cycles in Bacillus subtilis<\/em>. Proc Natl Acad Sci USA<\/em>\u00a0104<\/strong>, 17582-17587.<\/a><\/p>\n

Schultz, D<\/strong> ; Onuchic, JN; Wolynes, PG (2007) Understanding stochastic simulations of the smallest genetic networks. J Chem Phys<\/em>\u00a0126<\/strong>, 245102.<\/a><\/p>\n

Hornos, JEM; Schultz, D<\/strong> ; Innocentini, GCP; Wang, J; Walczak, AM; Onuchic, JN; Wolynes, PG (2005) Self-regulating gene: An exact solution. Phys Rev E Stat Nonlin Soft Matter Phys<\/em>\u00a072<\/strong>, 051907.<\/a><\/p>\n

Computational chemistry:<\/strong><\/p>\n

Schultz, D<\/strong> ; Droppa, R Jr; Alvarez, F; dos Santos, MC (2003) Stability of small carbon-nitride heterofullerenes. Phys Rev Lett<\/em>\u00a090<\/strong>, 015501.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Dynamics of antibiotic responses: Stevanovic, M; Carvalho, JPT; Bittihn, P; Schultz, D. (2024) Dynamical model of antibiotic responses linking expression of resistance to metabolism explains emergence of heterogeneity during drug exposures. Phys Biol\u00a021, 036002. Schultz, D; Stevanovic, M; Tsimring, L. (2022) Optimal transcriptional regulation of dynamic bacterial responses to sudden [\u2026] <\/p>\n

<\/div>\n

Read More<\/a><\/p>\n","protected":false},"author":128,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-25","page","type-page","status-publish","hentry","author-128"],"_links":{"self":[{"href":"https:\/\/geiselmed.dartmouth.edu\/schultz\/wp-json\/wp\/v2\/pages\/25","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/geiselmed.dartmouth.edu\/schultz\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/geiselmed.dartmouth.edu\/schultz\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/schultz\/wp-json\/wp\/v2\/users\/128"}],"replies":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/schultz\/wp-json\/wp\/v2\/comments?post=25"}],"version-history":[{"count":13,"href":"https:\/\/geiselmed.dartmouth.edu\/schultz\/wp-json\/wp\/v2\/pages\/25\/revisions"}],"predecessor-version":[{"id":226,"href":"https:\/\/geiselmed.dartmouth.edu\/schultz\/wp-json\/wp\/v2\/pages\/25\/revisions\/226"}],"wp:attachment":[{"href":"https:\/\/geiselmed.dartmouth.edu\/schultz\/wp-json\/wp\/v2\/media?parent=25"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}