QBS 147/BIOL 47: Genomics: From Data to Analysis

Course Director: Dr. Olga Zhaxybayeva

  • Course description: Massive amounts of genomic data pervade 21st century life science. Physicians now assess the risk and susceptibility of their patients to disease by sequencing the patient’s genome. Scientists design possible vaccines and treatments based on the genomic sequences of viruses and bacterial pathogens. Better-yielding crop plants are assessed by sequencing their transcriptomes. Moreover, we can more fully explore the roots of humanity by comparing our genomes to those of our close ancestors (e.g., Neanderthals, Denisovans). In this course, students will address real-world problems using the tools of modern genomic analyses. Each week students will address a problem using different types of genomic data, and use the latest analytical technologies to develop answers. Topics will include pairwise genome comparisons, evolutionary patterns, gene expression profiles, genome-wide associations for disease discovery, non-coding RNAs, natural selection at the molecular level, and metagenomic analyses.
  • Prerequisites:
    • Coursework: N/A.
    • Programming: N/A.

Syllabus