Enrichment Faculty

Angeline S. Andrew, Ph.D.

Assistant Professor of Epidemiology and of Community and Family Medicine
Research Description: Molecular diagnostics for bladder and lung cancers, toxic metal carcinogenesis, genetic susceptibility, gene-environment interactions.

Robert A. Darnall, M.D.

Professor of Molecular and Systems Biology, and of Pediatrics
Research Description: The role of medullary serotonin and GABA in the Sudden Infant Death Syndrome. Arousal in response to hypoxia is impaired after serotonin depletion and dependent on medullary GABAergic mechanisms.

Valerie Anne Galton, Ph.D.

Professor of Molecular and Systems Biology
Research Description: The roles of the iodothyronine deiodinases in the regulation of intracellular thyroid hormone levels and thyroid hormone action during development and in adult mammals. Studies use mice made deficient in the either or both the types 1 and 2 iodothyronine deiodinase.

Paul M. Guyre, Ph.D.

Professor of Microbiology & Immunology
Research Description: Mechanisms of hormone/cytokine interactions in control of immunity, Inflammation, sepsis, and autoimmunity.

Stephen Lee, M.D., Ph.D.

Assistant Professor of Neurology
Co-medical Director, The Parkinson Center at DHMC

Research Description: Molecular pathogenesis of Parkinson's disease; The laboratory studies the biological function of Parkinson's disease-associated genes using genetic, molecular, cellular, and model organism approaches.

James C. Leiter, M.D.

Professor of Molecular and Systems Biology and of Medicine
Research Description: Respiratory neurobiology especially in the areas of pH regulation in neurons and astrocytes, central chemosensitivity and comparative aspects of rhythm generation.

Lionel D. Lewis, M.D.

Professor of Medicine
Research Description: The study of novel antineoplastic agents and their pharmacokinetics and pharmacodynamics when first given to cancer patients (i.e. first time in man, Phase I studies of new drugs in cancer patients); mechanisms of toxicity of nucleoside analogues and antineoplastic agents to the mitochondrion and ways of ameliorating this toxicity.

Christopher H. Lowrey, M.D.

Professor of Medicine; Chief, Division of Hematology; Vice Chair, Department of Medicine
Research Description: Role of epigenetics and cell stress signaling in normal and disease-related blood cell production; development of novel pharmacologic therapies for sickle cell disease, thalassemia and leukemia.

Robert A. Maue, Ph.D.

Professor of Medical Education and of Biochemistry
Research Description: Cellular and molecular mechanisms underlying neuronal development in the CNS, particularly as related to neurodegenerative diseases; neurotrophin and growth factor actions; regulation of neuronal ion channels and genes; molecular biology; electrophysiology.

Eugene E. Nattie, M.D.

Professor of Molecular and Systems Biology
Research Description: Central chemoreceptors that sense changes in brain pH and stimulate breathing. The role of central chemoreception in the medullary raphe in the sudden infant death syndrome. The role of central chemoreceptors in hypertension.

William G. North, Ph.D.

Professor of Molecular and Systems Biology
Research Description: Neuropeptides in breast cancer, in small-cell carcinoma, and in Alzheimer's disease.

Mark Spaller, Ph.D.

Associate Professor of Molecular and Systems Biology
Research Description: Discovery and development of cellular probes and therapeutic agents targeting protein-protein interactions; chemical biology; peptide and organic small molecule synthesis; combinatorial chemistry; chemical libraries for in vitro and cell-based screening; biophysical analysis of protein-ligand interactions.

Matthew P. Vincenti, Ph.D.

Associate Professor of Medicine
Research Description: Regulation of matrix metalloproteinase gene expression in arthritis and cancer. The major goal of this work is to understand how inflammatory signal transduction activates metalloproteinase transcription.

Charles R. Wira, Ph.D.

Professor of Microbiology and Immunology
Research Description: Physiology of reproduction; cellular and molecular actions of sex hormones regulation of the mucosal immune system in the rodent and human female reproductive tract as it relates to protection against sexually transmitted diseases including HIV-1.

Heather A. Wishart, Ph.D.

Associate Professor of Psychiatry and of Neurology
Research Description: Functional and Structual Magnetic Resonance Imaging: Neurobiological basis of heterogeneity in multiple sclerosis. A hallmark of multiple sclerosis (MS) is its interindividual heterogeneity. Dr. Wishart's research program uses structural and functional MRI and genotyping to discover neurobiological mechanisms of heterogeneity in symptomatology, course and treatment response in MS, with the ultimate aim of improving early, individualized characterization and treatment of the disease.