Primary Cancer Biology, Pharmacology and Molecular Therapeutics Faculty

Brock C. Christensen, Ph.D.

Photograph by Jon Gilbert Fox
Associate Professor of Epidemiology, Molecular and Systems Biology, and of Community and Family Medicine
Research Description: Epigenetic and genetic molecular epidemiology with a focus on etiologic exposures, risk, and outcomes of human cancers as they relate to DNA methylation, miRNA expression, and miRNA-related polymorphisms.

Michael Cole, Ph.D.

Professor of Molecular and Systems Biology, Norris Cotton Cancer Center Member
Research Description: Molecular basis of cancer; with emphasis on the role of transcription factors and chromatin modification on tumor cell growth with major emphasis on the Myc oncogen family and its role in the growth of both cancer and normal cells.

Alan R. Eastman, Ph.D.

Professor of Molecular and Systems Biology, Director, Molecular Therapeutics Program, NCCC
Research Description: Cancer chemotherapy. Mechanisms of drug action: unbiased screen for novel drug targets and identification of selective anticancer drugs. Novel drug combinations: modulation of cell cycle arrest induced by DNA damaging agents; modulation of Bcl-2 proteins to enhance apoptosis.

Diane Gilbert-Diamond, ScD

Assistant Professor of Epidemiology and of Community and Family Medicine
Research Description: Dr. Gilbert-Diamond's research lab focuses on gene-environment interactions related to child growth and health including in utero exposures to toxic metals and vitamin D as well as early life exposures to electronic media and unhealthy diets.

Arminja Kettenbach, Ph.D.

Assistant Professor of Biochemistry and Cell Biology
Research Description: Research in my laboratory focuses on uncovering novel roles of phosphatases in cellular signaling networks in normal tissues and in cancer. We use a mass spectrometry-based approach to study phosphatase signaling on a system-wide level in cells, and reconstitute individual components in vitro to confirm, specify and validate them.

William B. Kinlaw, M. D.

Professor of Medicine (Endocrinology and Metabolism)
Research Description: We employ cell culture and genetically engineered mouse models to understand the metabolic peculiarities of breast tumors, and to explore their potential as therapeutic targets.

Periannan Kuppusamy, Ph.D.

Professor of Radiology and of Medicine
Research Description: Dr. Kuppusamy's research focusses on the determination of molecular mechanisms of the role of oxygen in the disease and treatment of myocardial injury (MI), and cancer. Specifically, the lab is interested in studying oxygen-sensing mechanism and signal transduction pathways at the molecular level leading to transcriptional and post-translational regulation of p53, PTEN, and PI3K. A significant part of the research utilizes an EPR-based measurement of oxygen (oximetry).

Steven D. Leach, M.D.

Preston T. and Virginia R. Kelsey Professor
Director of Norris Cotton Cancer Center
Research Description: pursues cellular, molecular and computational studies of pancreatic cancer and pancreatic development, using human tissue as well as mouse and zebrafish model systems. Recent studies have focused on how abnormal RNA splicing alters pancreatic cancer cell signaling, as well as the development of computational algorithms to predict which mutations in human pancreatic cancer are capable of eliciting an effective immune response.

Todd Miller, Ph.D.

Assistant Professor of Molecular and Systems Biology; Scientific Director, Comprehensive Breast Program, Norris Cotton Cancer Center; Co-Director, Molecular Tumor Board, Norris Cotton Cancer Center
Research Description: Research in the Miller Laboratory focuses on the translational application of knowledge of cell signaling pathways to therapeutics for breast cancer. Our work spans the spectrum of basic cancer biology, through translational studies in mouse models and human tissues, and interfaces with clinical trials. We use an array of methods and technologies both in our lab and through interaction with core facilities, including mammalian tissue culture, molecular analyses of gene and protein expression, gene expression microarrays, chromatin immunoprecipitation, next-generation DNA sequencing, bioinformatics, protein microarrays, mass spectrometry, mouse models, and live animal imaging.

Michael Passarelli, Ph.D.

Assistant Professor of Epidemiology
Research Description: Metabolism of steroids including sex hormones, cholesterol, and bile acids in relation to the development and recurrence of colorectal polyps and cancers.

Yolanda Sanchez, Ph.D.

Associate Professor of Molecular and Systems Biology
Associate Director for Basic Sciences, Norris Cotton Cancer Center

Research Description: Checkpoint signaling events triggered during the response to DNA damage or replication interference, how they regulate cell cycle progression, DNA repair and cell death. The role of checkpoints in the etiology of cancer and as drug targets for therapeutic enhancers of genotoxic cancer drugs.

Radu V. Stan, MD, PhD

Associate Professor of Biochemistry, and of Pathology
Director, Optical Cell Imaging Facility; Co-Director, Irradiation, Pre-clinical Imaging and Microscopy Shared Resource, Norris Cotton Cancer Center

Research Description: Role of blood vessels in the pathogenesis of inflammatory disease and cancer. Using a broad variety of experimental approaches (e.g. genetically modified mouse models, cell biological approaches in cell culture and fluorescence and electron microscopy), our lab studies the biology of specific vascular endothelial gene products (i.e. PLVAP and interacting partners) and endothelial specific structures (e.g. fenestrae, caveolae, and vesiculo-vacuolar organelles) in normal cardiovascular function and the adaptive responses that occur in disease. A significant part of our work is devoted to developing novel therapeutic and diagnostic strategies for inflammation and cancer.

Harold M. Swartz, M.D., Ph.D.

Professor of Radiology, The Dartmouth Institute, and of Community and Family Medicine
Research Description: The development and application of Electron Paramagnetic Resonance (EPR) to viable systems, including human subjects and animal models, especially 1. oximetry for cancer and peripheral vascular disease. 2. techniques for after-the-fact dosimetry to meet the need for rapid and accurate triage in a population that has potentially been exposed to doses that could cause the acute radiation syndrome (ARS).

Craig Tomlinson, Ph.D.

Assistant Professor of Medicine, and of Molecular and Systems Biology
Research Description: Our laboratory studies the role of aryl hydrocarbon receptor in adult-onset diseases from in utero exposures to environmental toxicants, pancreatic cancer, and the development of high throughput genomics as a tool to predict the outcome of gene/environment interactions.

Gregory J. Tsongalis, Ph.D.

Professor of Pathology
Research Description: Greg Tsongalis is the Director of the Laboratory for Clinical Genomics and Advanced Technologies (CGAT) at the Geisel School of Medicine. His area of expertise is in clinical molecular diagnostic applications. His research interests are in the pathogenesis of solid tumors, disease association of SNP genotyping and personalized medicine.

Enrichment Faculty

Angeline S. Andrew, Ph.D.

Assistant Professor of Epidemiology and of Community and Family Medicine
Research Description: Molecular diagnostics for bladder and lung cancers, toxic metal carcinogenesis, genetic susceptibility, gene-environment interactions.

Lionel D. Lewis, M.D.

Professor of Medicine
Research Description: The study of novel antineoplastic agents and their pharmacokinetics and pharmacodynamics when first given to cancer patients (i.e. first time in man, Phase I studies of new drugs in cancer patients); mechanisms of toxicity of nucleoside analogues and antineoplastic agents to the mitochondrion and ways of ameliorating this toxicity.

Christopher H. Lowrey, M.D.

Professor of Medicine; Chief, Division of Hematology; Vice Chair, Department of Medicine
Research Description: Role of epigenetics and cell stress signaling in normal and disease-related blood cell production; development of novel pharmacologic therapies for sickle cell disease, thalassemia and leukemia.

Mark Spaller, Ph.D.

Associate Professor of Molecular and Systems Biology
Research Description: Discovery and development of cellular probes and therapeutic agents targeting protein-protein interactions; chemical biology; peptide and organic small molecule synthesis; combinatorial chemistry; chemical libraries for in vitro and cell-based screening; biophysical analysis of protein-ligand interactions.

Matthew P. Vincenti, Ph.D.

Associate Professor of Medicine
Research Description: Regulation of matrix metalloproteinase gene expression in arthritis and cancer. The major goal of this work is to understand how inflammatory signal transduction activates metalloproteinase transcription.