Primary Faculty A-L
Associate Professor of Medicine and of Anesthesiology
Research Description: Currently my laboratory is investigating the potential mechanisms of increased lung inflammation in patients with inflammatory lung diseases, with an emphasis on the investigation of impaired alveolar macrophage function in these patient populations. Currently, my laboratory is particularly interested in how hypoxia impacts macrophage phenotype and function and how these changes in the immune cell may contribute to the chronic inflammation seen in patients with asthma and cystic fibrosis.
Professor of Molecular and Systems Biology
Research Description: We are interested in understanding how nuclear architecture, chromosome morphology and chromatin structure are modified in response to developmental cues and environmental factors. We are also interested in elucidating the molecular mechanisms through which these modifications function and effect specialized cellular processes.
Chair, Department of Psychological and Brain Sciences
Ralph and Richard Lazarus Professor of Psychological and Brain Sciences
Research Description: Behavioral and neurobiological factors that modulate learning and memory. Of particular interest are the neural mechanisms that are at the interface between attention and learning. We combine classical conditioning procedures with biochemical, pharmacological, and neuroanatomical techniques to study the role of cortical structures and subcortical neurochemical systems in these processes.
Assistant Professor of Medicine
Research Description: The research focus of our laboratory is to investigate the cellular and molecular mechanisms of autoimmune and neurological diseases using animal models, translational research, and clinical studies.
Photograph by Jon Gilbert Fox
Associate Professor of Epidemiology, Molecular and Systems Biology, and of Community and Family Medicine
Research Description: Epigenetic and genetic molecular epidemiology with a focus on etiologic exposures, risk, and outcomes of human cancers as they relate to DNA methylation, miRNA expression, and miRNA-related polymorphisms.
Professor of Molecular and Systems Biology, Norris Cotton Cancer Center Member
Research Description: Molecular basis of cancer; with emphasis on the role of transcription factors and chromatin modification on tumor cell growth with major emphasis on the Myc oncogen family and its role in the growth of both cancer and normal cells.
Assistant Professor of Psychiatry
Research Description: Using pre-clinical models to study the neurobiology and treatment development for disorders of appetitive behavior (e.g. substance use, eating disorders and obesity). Current methodologies include a combination of awake-behaving electrophysiology and focal neuromodulation using deep brain stimulation.
Professor of Molecular and Systems Biology, Director, Molecular Therapeutics Program, NCCC
Research Description: Cancer chemotherapy. Mechanisms of drug action: unbiased screen for novel drug targets and identification of selective anticancer drugs. Novel drug combinations: modulation of cell cycle arrest induced by DNA damaging agents; modulation of Bcl-2 proteins to enhance apoptosis.
Professor of Medicine and Microbiology/Immunology
Vice-Chair for Research
Chief, Pulmonary/Critical Care
Research Description: T cell responses to influenza and other virus infection, and the mechanisms of immunopathology in respiratory virus infection.
Professor of Psychiatry
Director, Neuropsychology Program
Research Description: Neural mechanisms of cognitive complaints and deficits after Traumatic Brain Injury (TBI) and other neuropsychiatric disorders, including schizophrenia and Alzheimer's disease. Neural correlates of unawareness of illness and potential sources of outcome variance after seemingly similar injuries, including genetic risk factors, brain efficiency, premorbid factors, and response to treatment, using structural and functional MRI (fMRI) and genetics. Understand the effects of repetitive biomechanical force exposure in concussed and non-concussed collegiate and high school football and hockey players.
Assistant Professor of Epidemiology and of Community and Family Medicine
Research Description: Dr. Gilbert-Diamond's research lab focuses on gene-environment interactions related to child growth and health including in utero exposures to toxic metals and vitamin D as well as early life exposures to electronic media and unhealthy diets.
Assistant Professor of Neurology
Research Description: We are interested in understanding the neuroimmunology of Multiple Sclerosis (MS) and its rodent models. Particularly, we are investigating the cellular and molecular pathways that contribute to neuroinflammation and central nervous system (CNS)-related tissue damage, aiming at understanding how inflammation contributes to neurodegeneration and disability progression in MS. The overall intention of this work is to identify new therapeutic targets or strategies that will improve our ability to manage progressive MS as well as other neurodegenerative diseases.
Professor of Psychological & Brain Sciences
Research Description: We study computational and cognitive neuroscience: analyses of how our brains operate to perceive, comprehend and manipulate their environments, as well as how they fail in certain conditions. We strive both to understand and analyze brain circuits, and, where possible, to construct equivalent circuits -- ranging from fMRI neuroimaging studies to robotics. Throughout these studies, real-world applications are developed as our understanding deepens.
Raymond Sobel Professor of Psychiatry; Chair, Department of Psychiatry
Research Description: Animal and human studies of the actions of antipsychotic drugs, as related to their use in patients with schizophrenia and substance use disorders. The work focuses on brain reward circuitry, and manipulation of this circuitry by antipsychotic drugs and other psychoactive agents.
Professor and Chair, Department of Microbiology and Immunology
Research Description: T cell immune responses to viral diseases; cell-mediated immunity to mouse retroviruses that cause either leukemia or immunodeficiency; immunity to the mouse acquired immunodeficiency syndrome (MAIDS) retroviral isolate and the mechanism of retroviral pathogenesis; studies on novel vaccine approaches.
Associate Professor of Molecular and Systems Biology
Research Description: Our focus is the cellular neurophysiology of the cerebral cortex, with emphasis on understanding signal integration and transmission within individual neurons.
Assistant Professor of Molecular and Systems Biology
Research Description: Molecular events contributing to the initiation and progression of Parkinson's disease. Investigating the neuroinflammatory activities of disease associated environmental toxins using molecular, cellular and organismal approaches.
Associate Professor of Psychiatry and of Surgery
Research Description: Neurobiology and treatment of mood disorders, primarily treatment-resistant depression. Current methodologies include functional and structural neuroimaging and focal neuromodulation techniques such as transcranial magnetic stimulation and deep brain stimulation.
Assistant Professor of Biological Sciences
Research Description: The focus of this lab is the study of the molecular basis of neuronal excitability in the mammalian brain. Our primary interests lie in understanding the biology of the axon initial segment, how ion channels localize there and what controls their ability to generate action potentials and modulate neurotransmitter release.
Professor of Medicine and of Microbiology and Immunology
Research Description: My laboratory studies the use of genome engineering using CRISPR/Cas to cleave both viral and cellular genes important for HIV infection and replication. We deliver these genes with lentiviral vectors and have shown we can both eliminate the HIV provirus from an infected cell as well as protect an uninfected cell from infection.
Professor of Neurology
Research Description: Neurophysiology of cognitive deficit in patients with epilepsy. Patients are implanted with intracranial electrodes for epilepsy surgery and cognitive tasks are performed while single neuron activity is recorded from the human brain. Also researches brain stimulation for the treatment of epilepsy and memory deficits.
Professor of Psychological and Brain Sciences
Research Description: My research uses functional magnetic resonance imaging (fMRI) to gain a better understanding of human memory formation. Specifically, my work focuses on how different kinds of information like words (verbal) or unfamiliar faces (non-verbal) are encoded into long-term memory. A related focus of my work is to use imaging techniques to explore how memory formation may become compromised as a result of damage to certain brain regions.
Assistant Professor of Biochemistry and Cell Biology
Research Description: Research in my laboratory focuses on uncovering novel roles of phosphatases in cellular signaling networks in normal tissues and in cancer. We use a mass spectrometry-based approach to study phosphatase signaling on a system-wide level in cells, and reconstitute individual components in vitro to confirm, specify and validate them.
Professor of Medicine (Endocrinology and Metabolism)
Research Description: We employ cell culture and genetically engineered mouse models to understand the metabolic peculiarities of breast tumors, and to explore their potential as therapeutic targets.
Professor of Radiology and of Medicine
Research Description: Dr. Kuppusamy's research focusses on the determination of molecular mechanisms of the role of oxygen in the disease and treatment of myocardial injury (MI), and cancer. Specifically, the lab is interested in studying oxygen-sensing mechanism and signal transduction pathways at the molecular level leading to transcriptional and post-translational regulation of p53, PTEN, and PI3K. A significant part of the research utilizes an EPR-based measurement of oxygen (oximetry).
Preston T. and Virginia R. Kelsey Professor
Director of Norris Cotton Cancer Center
Research Description: pursues cellular, molecular and computational studies of pancreatic cancer and pancreatic development, using human tissue as well as mouse and zebrafish model systems. Recent studies have focused on how abnormal RNA splicing alters pancreatic cancer cell signaling, as well as the development of computational algorithms to predict which mutations in human pancreatic cancer are capable of eliciting an effective immune response.
Associate Professor of Molecular and Systems Biology
Research Description: The general theme of the research is the control of breathing, blood pressure and sympathetic nerve activity by hypothalamus and brainstem, with specific emphasis on the roles of central chemoreceptors in cardiorespiratory functions and in health and diseases e.g. neurogenic hypertension, sleep disorders and sudden infant death syndrome.
Assistant Professor of Molecular and Systems Biology
Research Description: We study the molecular mechanisms that direct the formation of synapses onto new neurons as they integrate into the synaptic circuitry of the central nervous system.