Welcome to the Lab
Welcome to the Obar Laboratory in the Department of Microbiology and Immunology at the Geisel School of Medicine at Dartmouth in Lebanon, New Hampshire. Our laboratory is focused on elucidating the mechanisms by which inflammatory leukocytes are recruited to the lungs during infections to mediate either resistance to infection, in most cases, or lead to tissue immunopathology if they are inappropriately recruited to or activated in the tissue. Specifically, we are interested in two experimental systems: 1) viral infection with influenza A virus (IAV) and 2) fungal infection with Aspergillus fumigatus. Overall, the focus of our current studies is to understand the molecular mechanisms through which these pathogens interact with host cells and how these interactions may differ with different isolates of each pathogen in the hope of developing novel and/or improved therapeutic interventions.