{"id":15669,"date":"2022-01-21T09:15:07","date_gmt":"2022-01-21T14:15:07","guid":{"rendered":"https:\/\/geiselmed.dartmouth.edu\/news\/?p=15669"},"modified":"2022-01-21T09:15:07","modified_gmt":"2022-01-21T14:15:07","slug":"can-neonatal-herpes-lead-to-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/geiselmed.dartmouth.edu\/news\/2022\/can-neonatal-herpes-lead-to-alzheimers-disease\/","title":{"rendered":"Can Neonatal Herpes Lead to Alzheimer\u2019s Disease?"},"content":{"rendered":"
\"\"<\/a>
MD-PhD student Abby Dutton. Photo by Eli Burakian D'00<\/figcaption><\/figure>\n

\u201cWe\u2019ve learned a lot during the course of the COVID-19 pandemic \u2026 how a virus can affect our behavior,\u201d MD and PhD candidate Abigail Dutton says in this short video that recently won second place in the 2021 Ivy+ Three-minute Thesis Competition. \u201cBut recent evidence suggests that other viruses may be capable of causing permanent changes to host behavior in the absence of social pressures.\u201d<\/p>\n

In a\u00a0lab at the Geisel School of Medicine<\/a>\u00a0directed by\u00a0David Leib<\/a>, professor of microbiology and immunology, Dutton, while taking precautions against COVID-19, is studying one of those \u201cother viruses\u201d\u2014herpes simplex.<\/p>\n

\u201cIt is likely that over two-thirds of us are infected with HSV right now,\u201d Dutton warns. \u201cIt has the potential to survive, latent, within our nervous system for decades, traveling not only to the skin, but to the brain.\u201d Dutton has been testing a troubling hypothesis that herpes, in mice, can impair memory and learning in ways that resemble the toll taken on humans by Alzheimer\u2019s disease.<\/p>\n

In one of her experiments, a herpes-infected mouse on day one shares a box with two identical objects for 10 minutes. On day two, one of those objects is replaced with something different. A typically curious mouse, Dutton hypothesized, would be more interested by the new object than the old one.<\/p>\n

\u201cExactly the opposite happened,\u201d she says. \u201cThe infected mouse did not show a preference for the new object, suggesting a deficit in its ability to learn and remember \u2018novel\u2019 versus \u2018familiar.\u2019\u201d<\/p>\n

Read full story on Dartmouth College's website...<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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