{"id":15178,"date":"2021-08-19T14:20:12","date_gmt":"2021-08-19T18:20:12","guid":{"rendered":"https:\/\/geiselmed.dartmouth.edu\/news\/?p=15178"},"modified":"2021-08-25T14:31:50","modified_gmt":"2021-08-25T18:31:50","slug":"geisel-and-dartmouth-hitchcock-receive-grant-to-monitor-covid-19-variants-in-the-region","status":"publish","type":"post","link":"https:\/\/geiselmed.dartmouth.edu\/news\/2021\/geisel-and-dartmouth-hitchcock-receive-grant-to-monitor-covid-19-variants-in-the-region\/","title":{"rendered":"Geisel and Dartmouth-Hitchcock Receive Grant to Monitor COVID-19 Variants in the Region"},"content":{"rendered":"
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A team of researchers and clinicians at Dartmouth\u2019s Geisel School of Medicine and Dartmouth-Hitchcock Medical Center has begun working together on a National Institutes of Health grant to track the development and spread of COVID-19 variants that are detected in the Upper Valley. From left to right, Michael L. Whitfield, PhD, a professor of biomedical data science and of molecular and systems biology and chair of the Department of Biomedical Data Science at Geisel, and Joel A. Lefferts, PhD, primary investigator on the study and assistant director of Clinical Genomics and Advanced Technology lab at DHMC, work in the lab. Photo by Mark Washburn<\/figcaption><\/figure>\n

A team of researchers and clinicians at Dartmouth\u2019s Geisel School of Medicine and Dartmouth-Hitchcock Medical Center (DHMC) has begun working together on a National Institutes of Health (NIH) grant to track the development and spread of COVID-19 variants that are detected in the Upper Valley.<\/p>\n

The one-year project is part of an initiative by the NIH\u2019s National Institute of General Medical Sciences (NIGMS) to support surveillance studies of SARS-CoV-2 viral strains in rural, underserved communities. The NIGMS has awarded a total of $15 million to 21 centers in the effort to advance research on the emergence, evolution, and infectivity of variants circulating in the U.S.<\/p>\n

\u201cIt\u2019s extremely important for us to be able to identify and monitor variants of concern, such as the recent Delta variant, in our local population to inform public health efforts and to aid in the development of any future vaccines that may be needed,\u201d says Michael L. Whitfield, PhD, a professor of biomedical data science and of molecular and systems biology and chair of the Department of Biomedical Data Science at Geisel, who secured the grant funding and is helping to lead the effort.<\/p>\n

DHMC\u2019s Clinical Genomics and Advanced Technology (CGAT) laboratory has begun to perform sequencing on some retrospective and all prospective positive patient samples.<\/p>\n

\u201cOur lab was among the first in the Northeast to begin sequencing the novel coronavirus back in August of 2020,\u201d says Gregory J. Tsongalis, PhD, who directs the CGAT at DHMC. \u201cSince then, we\u2019ve sequenced over 120 samples. Continued sequencing of our stored samples, made possible by this grant, should yield very interesting results and will allow us to see when some of these variants first appeared in our region. We\u2019re learning about this virus in real time, and sequencing is a valuable tool in helping to understand its complexities and developing treatments and, hopefully someday, a cure.\u201d<\/p>\n

The medical center will handle retrieval and preparation of about 4,000 archived COVID-19 specimens from the CGAT lab\u2019s freezers that have been collected since the start of the pandemic.<\/p>\n

The project team will also be working with the University of New Hampshire\u2019s genomic laboratory, which has collaborated with Dartmouth in the past, and will be assisting on the front end of the project.<\/p>\n

\u201cWe\u2019ll be sequencing a large set of the historical samples,\u201d says Kelley Thomas, PhD, professor of molecular, cellular, and biomedical sciences and director of the Hubbard Center for Genomic Studies at UNH. \u201cThen, their researchers will take the raw data and do the back-end analyses, which Dartmouth is one of the best in the country at.\u201d<\/p>\n

These analyses, which will include epidemiological and bioinformatics studies of the variants, will leverage resources from a 5-year, $12.5 million Center for Biomedical Research Excellence (COBRE) grant from the NIGMS that Whitfield received in 2019, that helped him establish the Center for Quantitative Biology at Dartmouth.<\/p>\n

New positive COVID-19 specimens collected at DHMC going forward will be sequenced at the CGAT lab, says Joel A. Lefferts, PhD, primary investigator on the study and assistant director of CGAT.<\/p>\n

\u201cWe will also be able to link available demographic and clinical information to the samples to explore possible correlations,\u201d Lefferts explains. \u201cAll sequence data will be uploaded into public repositories to increase representation of rural New England cases in SARS-CoV-2 sequence databases.\u201d<\/p>\n

Cassidy M. Smith at D-H also contributed to this release.<\/em><\/p>\n

Founded in 1797, the\u00a0Geisel School of Medicine at Dartmouth <\/strong>strives to improve the lives of the communities it serves through excellence in learning, discovery, and healing. The Geisel School of Medicine is renowned for its leadership in medical education, healthcare policy and delivery science, biomedical research, global health, and in creating innovations that improve lives worldwide. As one of America\u2019s leading medical schools, Dartmouth\u2019s Geisel School of Medicine is committed to training new generations of diverse leaders who will help solve our most vexing challenges in healthcare.<\/p>\n

About Dartmouth-Hitchcock Health:<\/strong>\u00a0DARTMOUTH-HITCHCOCK<\/a> HEALTH<\/u> (D-HH), New Hampshire\u2019s only academic health system and the state\u2019s largest private employer, serves a population of 1.9 million across northern New England. D-H provides access to more than 2,000 providers in almost every area of medicine, delivering care at its flagship hospital, Dartmouth-Hitchcock Medical Center (DHMC) in Lebanon, NH. DHMC was named again in 2020 as the #1 hospital in New Hampshire by U.S. News & World Report<\/em><\/a>,<\/em> and recognized for high performance in 9 clinical specialties and procedures. Dartmouth-Hitchcock also includes the\u00a0Norris Cotton Cancer Center<\/a>, one of only 51 NCI-designated Comprehensive Cancer Centers in the nation; the\u00a0Children's Hospital at Dartmouth-Hitchcock<\/a>, the state\u2019s only children\u2019s hospital<\/u>; affiliated member hospitals in Lebanon, Keene, and New London, NH, and Windsor, VT, and Visiting Nurse and Hospice for Vermont and New Hampshire; and 24 Dartmouth-Hitchcock clinics that provide ambulatory services across New Hampshire and Vermont. The D-H system trains nearly 400 residents and fellows annually, and performs world-class research, in partnership with the\u00a0Geisel School of Medicine\u00a0at Dartmouth<\/a> and the\u00a0White River Junction VA Medical Center<\/a>\u00a0in White River Junction, VT.<\/p>\n","protected":false},"excerpt":{"rendered":"

A team of researchers and clinicians at Geisel and Dartmouth-Hitchcock has begun working together on a National Institutes of Health grant to track the development and spread of COVID-19 variants that are detected in the Upper Valley.<\/p>\n","protected":false},"author":26,"featured_media":15179,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1,182],"tags":[966],"class_list":["post-15178","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-press-release-news","tag-covid-19","author-26"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-content\/uploads\/sites\/2\/2021\/08\/WhitfieldCOVID_featured.jpg","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p4r3h1-3WO","_links":{"self":[{"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/posts\/15178","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/comments?post=15178"}],"version-history":[{"count":4,"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/posts\/15178\/revisions"}],"predecessor-version":[{"id":15212,"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/posts\/15178\/revisions\/15212"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/media\/15179"}],"wp:attachment":[{"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/media?parent=15178"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/categories?post=15178"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/tags?post=15178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}