{"id":12854,"date":"2020-01-13T15:57:39","date_gmt":"2020-01-13T20:57:39","guid":{"rendered":"https:\/\/geiselmed.dartmouth.edu\/news\/?p=12854"},"modified":"2020-01-15T11:32:35","modified_gmt":"2020-01-15T16:32:35","slug":"new-mechanism-may-safely-prevent-and-reverse-obesity","status":"publish","type":"post","link":"https:\/\/geiselmed.dartmouth.edu\/news\/2020\/new-mechanism-may-safely-prevent-and-reverse-obesity\/","title":{"rendered":"New Mechanism May Safely Prevent and Reverse Obesity"},"content":{"rendered":"

Researchers at Dartmouth\u2019s and Dartmouth-Hitchcock\u2019s Norris Cotton Cancer Center have discovered that a receptor found in almost all cells plays a big role in the body's metabolism. By blocking the receptor with use of a drug, mice on a high-fat diet did not become any fatter than mice on a low-fat control diet, and obese mice dropped in weight with use of the same drug. No ill side effects were observed in either study.\u00a0<\/span><\/p>\n

Obesity, a global epidemic, is a known contributor to several cancers, including breast, colon, and pancreatic. Stopping the obesity epidemic could be a critical aid in preventing and treating numerous cancers. Researchers with the laboratory of Craig Tomlinson, PhD, at Dartmouth\u2019s and Dartmouth-Hitchcock\u2019s Norris Cotton Cancer Center have found a critical target in this cause. The team discovered that a receptor found in almost all cells, called AHR, and known primarily to combat exposures to environmental chemicals, also plays a big role in the body's metabolism. Blocking AHR not only prevented, but reversed obesity in study mice. The team\u2019s findings, \u201cReversal of obesity and liver steatosis in mice via inhibition of aryl hydrocarbon receptor and altered gene expression of CYP1B1, PPAR\u03b1, SCD1, and osteopontin<\/a>,\u201d are newly published in the International Journal of Obesity<\/i>.\u00a0<\/span><\/p>\n

\"\"<\/a>
Craig Tomlinson, Ph.D<\/figcaption><\/figure>\n

\u201cWe carried out experiments showing that when a drug named NF and known to block the AHR, was added to a high-fat diet, mice did not become any fatter than mice on a low-fat control diet,\u201d says Tomlinson. \u201cMice on the high-fat diet with no NF became very obese within the same time span. No ill effects were observed from the drug.\u201d\u00a0<\/span><\/p>\n

The team then asked whether blocking the AHR with NF could not only prevent obesity but reverse it. \u201cIn these experiments, we allowed the mice to become obese on a high-fat diet, and then half the mice were switched to the high-fat diet containing the AHR blocker NF. Over the next few weeks, the mice switched to the high-fat diet\u00a0<\/span><\/p>\n

containing NF dropped to the same body weight as those mice on the low-fat diet. The remaining mice on the high-fat diet became obese. Again, no ill effects were observed,\u201d explains Tomlinson.<\/p>\n

Finally, Tomlinson\u2019s team investigated the mechanisms behind how the AHR, when blocked by NF, prevented and reversed obesity. Using previous knowledge that the AHR regulates key genes in fat metabolism, the team discovered that in liver cells and in fat cells, the AHR, when blocked by NF, fails to induce several key genes required for fat storage and synthesis. They concluded that the prevention and reversal of obesity from blocking the activity of the AHR is due to key genes regulated by the AHR that are involved in fat metabolism. \u201cFew to no studies have shown that obesity can be reversed by a drug treatment; it is even rarer to know the underlying cellular mechanism,\u201d notes Tomlinson.\u00a0<\/span><\/p>\n

Tomlinson\u2019s team has begun investigating several key questions, including those around the dietary compounds in the food we eat that activate the AHR to cause obesity, and the role that gut bacterial play regarding the AHR and obesity. Most importantly, they have initiated a clinical trial to determine whether the AHR may serve as a therapeutic target to reduce obesity in humans. \u201cWe are beginning to understand how the blockage of the AHR prevents and reverses obesity, which may lead to a therapeutic treatment of obesity in humans,\u201d says Tomlinson.<\/p>\n

Craig Tomlinson, PhD,<\/b>\u00a0 <\/span>is a Senior Research Scientist\/Analyst\/Engineer, Associate Director for Shared Resources, Director of the Genomics Shared Resource, and Member of the Cancer Biology & Therapeutics Research Program at Dartmouth\u2019s and Dartmouth-Hitchcock\u2019s Norris Cotton Cancer Center. His laboratory research focuses on the common theme of using high-throughput genomics approaches to study gene\/environment interactions in development and disease.<\/p>\n

About Norris Cotton Cancer Center at Dartmouth-Hitchcock<\/b>\u00a0<\/span><\/p>\n

Norris Cotton Cancer Center combines advanced cancer research at Dartmouth\u2019s Geisel School of Medicine with patient-centered cancer care provided at Dartmouth-Hitchcock Medical Center in Lebanon, NH, at Dartmouth-Hitchcock regional locations in Manchester, Nashua and Keene, NH, and St. Johnsbury, VT, and at partner hospitals throughout New Hampshire and Vermont. It is one of 51 centers nationwide to earn the National Cancer Institute\u2019s \u201cComprehensive Cancer Center\u201d designation. Learn more about Norris Cotton Cancer Center research, programs, and clinical trials online at cancer.dartmouth.edu.<\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers at Dartmouth\u2019s and Dartmouth-Hitchcock\u2019s Norris Cotton Cancer Center have discovered that a receptor found in almost all cells plays a big role in the body’s metabolism. By blocking the receptor with use of a drug, mice on a high-fat diet did not become any fatter than mice on a low-fat control diet, and obese mice dropped in weight with use of the same drug. No ill side effects were observed in either study. <\/p>\n","protected":false},"author":143,"featured_media":12859,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1,182,8],"tags":[957,176,73,320],"class_list":["post-12854","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-press-release-news","category-research","tag-cancer-research","tag-nccc","tag-obesity","tag-research-2","author-143"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-content\/uploads\/sites\/2\/2020\/01\/ScaleAndTapeMeasure.jpg","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p4r3h1-3lk","_links":{"self":[{"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/posts\/12854","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/users\/143"}],"replies":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/comments?post=12854"}],"version-history":[{"count":5,"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/posts\/12854\/revisions"}],"predecessor-version":[{"id":12877,"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/posts\/12854\/revisions\/12877"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/media\/12859"}],"wp:attachment":[{"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/media?parent=12854"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/categories?post=12854"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/news\/wp-json\/wp\/v2\/tags?post=12854"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}