Genetics (GENE)

The Genetics (GENE) Longitudinal Curriculum will oversee and assure that major foundational and clinical aspects of genetics are taught in a depth and in a manner appropriate for medical students. GENE will also work to assure that there is an appropriate level of reinforcement of genetic topics through the curriculum while avoiding redundancy.

Longitudinal Curricula Leaders

Larry Myers, PhD

Associate Professor
Departments of Medical Education, and Biochemistry and Cell Biology
Geisel School of Medicine at Dartmouth
7200 Vail Building,  Room 412 Vail
Hanover, New Hampshire 03755-3844
Tel.: (603) 650-1198 * Fax : (603) 650-1128


Mary Beth Dinulos, M.D.

Section Chief, Genetics and Child Development
Department of Pediatrics
Associate Professor of Pediatrics and Pathology
The Geisel School of Medicine at Dartmouth

Longitudinal Curriculum Objectives

  1. Genome organization/Gene regulation: Apply knowledge of the human genome structure and function, including genetic and epigenetic mechanisms, to explain how changes in gene expression influence disease onset and severity.
  2. Genetic Variation: Apply knowledge of genetic/genomic variation to explain variation in normal phenotypic expression, disease phenotypes and treatment options.
  3. Population Genetics: Apply basic concepts of population genetics to explain why allele frequencies vary between human ancestral populations, and to infer and calculate disease risk.
  4. Inheritance: Apply the basic principles of single gene and multifactorial inheritance to construct a pedigree, interpret a family history, estimate disease risk, and explain phenotypic variation.
  5. Cytogenetics and Molecular Genetics: Apply knowledge of cytogenetics and molecular genetics to describe the principles, uses and limitations of genetic testing technologies (to include GWAS and DTC genetic testing).
  6. Biochemical Genetics: Apply knowledge of biochemical pathways and genetic principles to describe, diagnose and treat biochemical disorders.
  7. Cancer Genetics: Apply knowledge of genetics/genomics to the development, diagnosis and treatment of cancer.
  8. Medical Genetics/Inheritance: Demonstrate the ability to gather family history information, construct and interpret a family pedigree, assess risk for a genetic disorder, and determine when a complete genetics evaluation is appropriate.
  9. Genetic Testing: Identify appropriate indications for genetic testing and recognize the limitations and implications for test results.
  10. Cancer Genetics: Recognize and describe indications for genetic referral for diagnosis, testing, treatment and counselling specifically related to cancer.
  11. Reproductive and Prenatal Genetics: Recognize and describe indications for genetic referral for diagnosis, testing, treatment and counselling specifically related to prenatal diagnosis.
  12. Treatment/Management: Apply knowledge of genetic variation and the etiology of genetic disorders to the selection of treatment options and strategies.
  13. Professionalism: Demonstrate respect, compassion, accountability and integrity when interacting with and communication genetic information to patients and peers.
  14. Systems Based Practice: Explain the ethical, legal and social implications of genetic information, and its impact on public policy.