Biochemistry (BIOC)

The Biochemistry Longitudinal Curriculum will examine incorporate aspects of biochemistry into courses and clerkships across the Geisel curriculum. BIOC will build upon and coordinate with the subject matter from the Foundations course (particularly the molecular mechanisms of cancer). Through this LC, there will be opportunities for students to connect the biochemistry of protein/nucleic acid structure/function relationships to various aspects of physiology and disease pathology.

Longitudinal Curriculum Leader

Larry Myers, PhD

Associate Professor
Departments of Medical Education, and Biochemistry and Cell Biology
Geisel School of Medicine at Dartmouth
7200 Vail Building,  Room 412 Vail
Hanover, New Hampshire 03755-3844
Tel.: (603) 650-1198 * Fax : (603) 650-1128


Longitudinal Curriculum Objectives

  1. Apply and integrate molecular and metabolic knowledge of conditions and disease states for clinical problem solving (e.g., sickle cell anemia, carcinogenesis, coronary artery disease).
  2. Apply molecular and metabolic reasoning to evaluate clinical and translational research.
  3. Select, justify, and interpret the results of clinical tests in order to identify likely molecular and metabolic causes of disease states (e.g., PCR, complete blood count, comprehensive metabolic panel).
  4. Based on patient history, physical exam, medical record, and/or laboratory test results, develop differential diagnoses for molecular and metabolic causes of disease states (e.g., metabolic acidosis, hyperbilirubinemia, hypoglycemia, hemolysis).
  5. Select and apply preventive, curative, and/or palliative strategies for the management of conditions or disease states with a molecular or metabolic basis (e.g., hypercholesterolemia, Lynch syndrome, hemoglobinopathies, glucose 6-phosphate dehydrogenase deficiency, PKU, lead poisoning).
  6. Predict the effectiveness of, and possible adverse effects associated with, interventions for conditions or diseases based on knowledge of molecular, genetic and cellular regulatory mechanisms (e.g., reduction of dietary trans fats for dyslipidemia, insulin analogs for hyperglycemia, allopurinol for hyperuricemia).
  7. Effectively explain to patients from a variety of backgrounds the molecular and metabolic basis of conditions and disease states and how lifestyle and/or therapeutic interventions can alter their manifestations.
  8. Communicate biochemical reasoning effectively with peers, medical school staff and faculty, and other members of the health care team.