{"id":36,"date":"2017-01-25T15:51:52","date_gmt":"2017-01-25T15:51:52","guid":{"rendered":"https:\/\/mednews2.dartmouth.edu\/leib\/?page_id=36"},"modified":"2023-08-31T08:43:19","modified_gmt":"2023-08-31T12:43:19","slug":"publications","status":"publish","type":"page","link":"https:\/\/geiselmed.dartmouth.edu\/leib\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Antibodies targeting HSV glycoprotein B require effector functions to protect neonatal mice.<\/a>
Slein MD, Jimenez LM, Backes IM, Turnbaugh EM, Garland CR, MacDonald SW, Balazs AB, Leib DA, Ackerman ME
J Virol. 2026 Apr 21;100(4):e0005026. doi: 10.1128\/jvi.00050-26. Epub 2026 Mar 9.
PMID: 41800909<\/p>

Prefusion-specific glycoprotein B human antibodies protect against neonatal HSV-2 infection.<\/a>
Amlashi P, Kim J, Mendis NN, Wasdin PT, Bass LE, Jordaan G, Abu-Shmais AA, Slein MD, Johnson NV, Bonami RH, Leib DA, Ackerman ME, McLellan JS, Georgiev IS
bioRxiv. 2026 Mar 25; pii: 2026.02.23.707514. doi: 10.64898\/2026.02.23.707514. Epub 2026 Mar 25.
PMID: 41929215<\/p>

Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice.<\/a>
Slein MD, Backes IM, Jimenez LM, Kelkar NS, Garland CR, Khanwalkar US, Sholukh AM, Johnston C, Leib DA, Ackerman ME
Sci Transl Med. 2025 Nov 19;17(825):eadu8579. doi: 10.1126\/scitranslmed.adu8579. Epub 2025 Nov 19.
PMID: 41259538<\/p>

Corrigendum to \"Herpes simplex virus 1 ICP34.5 acts to maintain latency in human and mouse neurons\" [Virology 611 (2025) 110652].<\/a>
Canova PN, Katzenell S, Ceron S, Charron AJ, Pesola JM, Oh HS, Coen DM, Knipe DM, Leib DA
Virology. 2025 Oct;611:110669. doi: 10.1016\/j.virol.2025.110669. Epub 2025 Aug 30.
PMID: 40885672<\/p>

Herpes simplex virus 1 ICP34.5 acts to maintain latency in human and mouse neurons.<\/a>
Canova PN, Katzenell S, Ceron S, Charron AJ, Pesola JM, Oh HS, Coen DM, Knipe DM, Leib DA
Virology. 2025 Oct;611:110652. doi: 10.1016\/j.virol.2025.110652. Epub 2025 Aug 12.
PMID: 40819480<\/p>

Maternal Antibodies to Neurovirulent Pathogens in Fetal Tissues.<\/a>
Slein MD, Ackerman ME, Leib DA
Annu Rev Virol. 2025 Sep;12(1):471-489. doi: 10.1146\/annurev-virology-092623-094004. Epub 2025 Apr 18.
PMID: 40249965<\/p>

Antibodies targeting HSV glycoprotein B require effector functions to protect neonatal mice.<\/a>
Slein MD, Jimenez LM, Backes IM, Turnbaugh EM, Garland CR, MacDonald SW, Balazs AB, Leib DA, Ackerman ME
bioRxiv. 2025 Jul 30; pii: 2025.07.25.666806. doi: 10.1101\/2025.07.25.666806. Epub 2025 Jul 30.
PMID: 40766354<\/p>

Herpes Simplex Virus Neurovirulence Across the Human Lifespan.<\/a>
Dutton AJ, Hayes CK, Leib DA, Akhtar LN
J Infect Dis. 2025 Jul 30;232(1):14-24. doi: 10.1093\/infdis\/jiaf275.
PMID: 40418737<\/p>

Regulation of the innate immune response in human neurons by ICP34.5 maintains herpes simplex virus 1 latency.<\/a>
Canova PN, Katzenell S, Ceron S, Charron AJ, Pesola JM, Oh HS, Coen DM, Knipe DM, Leib DA
bioRxiv. 2025 Apr 10; pii: 2025.04.04.647253. doi: 10.1101\/2025.04.04.647253. Epub 2025 Apr 10.
PMID: 40291710<\/p>

Asymptomatic neonatal herpes simplex virus infection in mice leads to persistent CNS infection and long-term cognitive impairment.<\/a>
Dutton AJ, Turnbaugh EM, Patel CD, Garland CR, Taylor SA, Alers-Velazquez R, Knipe DM, Nautiyal KM, Leib DA
PLoS Pathog. 2025 Feb;21(2):e1012935. doi: 10.1371\/journal.ppat.1012935. Epub 2025 Feb 7.
PMID: 39919123<\/p>

Improving antibody-mediated protection against HSV infection by eliminating interactions with the viral Fc receptor gE\/gI.<\/a>
Slein MD, Backes IM, Kelkar NS, Garland CR, Khanwalkar US, Sholukh AM, Johnston CM, Leib DA, Ackerman ME
bioRxiv. 2024 Nov 22; pii: 2024.11.20.624598. doi: 10.1101\/2024.11.20.624598. Epub 2024 Nov 22.
PMID: 39605495<\/p>

Models of Herpes Simplex Virus Latency.<\/a>
Canova PN, Charron AJ, Leib DA
Viruses. 2024 May 8;16(5) doi: 10.3390\/v16050747. Epub 2024 May 8.
PMID: 38793628<\/p>

Asymptomatic neonatal herpes simplex virus infection in mice leads to long-term cognitive impairment.<\/a>
Dutton A, Patel CD, Taylor SA, Garland CR, Turnbaugh EM, Alers-Velazquez R, Mehrbach J, Nautiyal KM, Leib DA
bioRxiv. 2024 Apr 22; pii: 2024.04.22.590596. doi: 10.1101\/2024.04.22.590596. Epub 2024 Apr 22.
PMID: 38712140<\/p>

Effector functions are required for broad and potent protection of neonatal mice with antibodies targeting HSV glycoprotein D.<\/a>
Slein MD, Backes IM, Garland CR, Kelkar NS, Leib DA, Ackerman ME
Cell Rep Med. 2024 Feb 20;5(2):101417. doi: 10.1016\/j.xcrm.2024.101417. Epub 2024 Feb 12.
PMID: 38350452<\/p>

Antibody effector functions are required for broad and potent protection of neonates from herpes simplex virus infection.<\/a>
Slein MD, Backes IM, Garland CR, Kelkar NS, Leib DA, Ackerman ME
bioRxiv. 2023 Aug 31; pii: 2023.08.29.555423. doi: 10.1101\/2023.08.29.555423. Epub 2023 Aug 31.
PMID: 37693377<\/p>\n

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