{"id":2546,"date":"2023-10-04T15:34:52","date_gmt":"2023-10-04T15:34:52","guid":{"rendered":"https:\/\/geiselmed.dartmouth.edu\/koop\/?page_id=2546"},"modified":"2026-02-26T22:20:34","modified_gmt":"2026-02-26T22:20:34","slug":"cannabis-research","status":"publish","type":"page","link":"https:\/\/geiselmed.dartmouth.edu\/koop\/research\/cannabis-research\/","title":{"rendered":"Cannabis Research"},"content":{"rendered":"

The Institute provides a home at Dartmouth for researchers who focus on behavior and non-communicable diseases. We conduct research that has a measurable impact on the risk of these diseases.<\/em><\/p>\n

Cannabis (aka marijuana) -- Over the past decade, the prevalence and frequency of cannabis use has increased along with an explosion of new cannabis products available to the public.\u00a0 Confusion, debate, and controversy related to the potential for cannabis use to cause harm, or alternatively to provide therapeutic benefit continues globally.\u00a0 Escalation of (a) the decriminalization and legalization of cannabis and cannabinoid products, (b) the perception that cannabis has therapeutic potential for a numerous and diverse set of disorders, and (c) a burgeoning and lucrative cannabis industry has increased the importance and urgency of gaining a better understanding of the impact of cannabis on public health and the development of a regulatory system that can best mitigate harm.\u00a0 Koop Institute investigators are involved in diverse areas of cannabis research, including: trials of novel interventions, development of tools to measure cannabis consumption, determining associations between use patterns and consequences, evaluation of cannabis policy on cannabis consumption and consequences, and prevalence and consequences of cannabis use. Koop faculty also routinely participate in educational activities to provide the most up to date information related to cannabis and its effects to youth, parents, students, health care professionals, policymakers, and the public.<\/p>\n

Selected Publications<\/h3>\n

Test-retest reliability of mgTHC consumption in the self-administered Cannabis Exposure Index (CEI).<\/a>
Hasin DS, Borodovsky J, Wall M, Habib MI, Murphy E, Liu J, Stohl M, Struble CA, Livne O, Greenstein E, Aharonovich E, Wisell CG, Budney AJ
Drug Alcohol Depend. 2026 Feb 1;279:113028. doi: 10.1016\/j.drugalcdep.2026.113028. Epub 2026 Jan 3.
PMID: 41546987<\/p>

Self-titration of cannabis consumption: An epidemiological perspective.<\/a>
Borodovsky JT, Murphy E, Hasin DS, Livne O, Wall M, Aharonovich E, Wisell C, Struble CA, Habib MI, Budney AJ
J Psychiatr Res. 2025 Nov;191:527-534. doi: 10.1016\/j.jpsychires.2025.09.014. Epub 2025 Sep 8.
PMID: 41061441<\/p>

Developing an online cannabis store paradigm for Cannabis Regulatory Science.<\/a>
Borodovsky JT, Bairaboina S, Struble CA, Preum SM, Sargent JD, Emond JA, Budney AJ
medRxiv. 2025 Oct 22; pii: 2025.10.20.25338387. doi: 10.1101\/2025.10.20.25338387. Epub 2025 Oct 22.
PMID: 41282889<\/p>

Impact of nicotine, cannabis, co-use and non-use on single day morning and evening cortisol and subjective state: During ambulatory assessment.<\/a>
Keogh TM, Budney A, Allen S, Hatsukami D, DeAngelis B, al'Absi M
Psychoneuroendocrinology. 2025 Oct;180:107567. doi: 10.1016\/j.psyneuen.2025.107567. Epub 2025 Aug 14.
PMID: 40816118<\/p>

Age Differences in Cannabis Consumption Patterns and in Associations Between Delta-9-Tetrahydrocannabinol Intake and Cannabis Use Disorders Among Adults with Daily Use.<\/a>
Livne O, Borodovsky J, Budney AJ, Wisell CG, Habib MI, Struble CA, Chen L, Liu J, Wall M, Aharonovich E, Hasin DS
Cannabis Cannabinoid Res. 2025 Jul 16;:25785125251360976. doi: 10.1177\/25785125251360976. Epub 2025 Jul 16.
PMID: 40667820<\/p>

Estimating Cannabis Consumption in Milligrams of THC From Self-Reported Hit Size.<\/a>
Habib MI, Budney AJ, Struble CA, Hasin DS, Livne O, Aharonovich E, Wisell C, Fragione SN, Borodovsky JT
Cannabis. 2025;8(2):153-163. doi: 10.26828\/cannabis\/2025\/000285. Epub 2025 Jul 15.
PMID: 40909144<\/p>

Patient-provider interactions about cannabis for therapeutic purposes vary as a function of provider type: A pilot study.<\/a>
Achar J, Budney AJ, Struble CA
Am J Addict. 2025 May;34(3):277-288. doi: 10.1111\/ajad.13656. Epub 2024 Oct 24.
PMID: 39446729<\/p>

Quantity of delta-9-tetrahydrocannabinol consumption and cannabis use disorder among daily cannabis consumers.<\/a>
Borodovsky JT, Hasin DS, Wall M, Struble CA, Habib MI, Livne O, Liu J, Chen L, Aharonovich E, Budney AJ
Addiction. 2025 Apr;120(4):676-685. doi: 10.1111\/add.16700. Epub 2024 Nov 6.
PMID: 39501796<\/p>

Randomized Laboratory Study of Single-Dose Cannabis, Dronabinol, and Placebo in Patients With Schizophrenia and Cannabis Use Disorder.<\/a>
Brunette MF, Roth RM, Trask C, Khokhar JY, Ford JC, Park SH, Hickey SM, Zeffiro T, Xie H
Schizophr Bull. 2025 Mar 14;51(2):479-492. doi: 10.1093\/schbul\/sbae097.
PMID: 38900958<\/p>

Momentary mindfulness versus distraction coping messages to reduce cannabis craving among young adults: A microrandomized trial.<\/a>
Stanger C, Anderson MAB, Xie H, Nnaka T, Budney AJ, Qian T, Yap JRT, Nahum-Shani I
Psychol Addict Behav. 2025 Mar;39(2):200-211. doi: 10.1037\/adb0001029. Epub 2024 Oct 17.
PMID: 39418443<\/p>

Impact of Early-Life Adversity on Cannabis Use: Exploring the Mediating and Moderating Effects of Chronic Pain.<\/a>
Hodges JS, DeAngelis BN, Borodovsky J, Budney A, al'Absi M
Cannabis Cannabinoid Res. 2025 Feb;10(1):e156-e164. doi: 10.1089\/can.2023.0218. Epub 2024 Mar 18.
PMID: 38498016<\/p>

Feasibility and utility of a structured guide for cannabis tolerance breaks in young adults.<\/a>
Fontana TJK, Schulz JA, Budney AJ, Villanti AC
J Am Coll Health. 2025 Jan;73(1):5-9. doi: 10.1080\/07448481.2022.2155061. Epub 2023 Jan 3.
PMID: 36595624<\/p>

Extending Gender- and Sex-Based Analyses in Cannabis Research: Findings from an Online Sample of Gender Diverse Young Adult Consumers.<\/a>
Struble CA, Borodovsky JT, Habib MI, Hasin DS, Shmulewitz D, Livne O, Walsh C, Aharonovich E, Budney AJ
Cannabis Cannabinoid Res. 2024 Dec;9(6):e1604-e1614. doi: 10.1089\/can.2023.0069. Epub 2023 Aug 18.
PMID: 37594777<\/p>

Inclusion of Individuals With Lived Experiences in the Development of a Digital Intervention for Co-Occurring Depression and Cannabis Use: Mixed Methods Investigation.<\/a>
Collins AC, Bhattacharya S, Oh JY, Salzhauer A, Taylor CT, Wolitzky-Taylor K, Aupperle RL, Budney AJ, Jacobson NC
JMIR Form Res. 2024 Oct 7;8:e54751. doi: 10.2196\/54751. Epub 2024 Oct 7.
PMID: 39374076<\/p>

From mood to use: Using ecological momentary assessments to examine how anhedonia and depressed mood impact cannabis use in a depressed sample.<\/a>
Collins AC, Lekkas D, Struble CA, Trudeau BM, Jewett AD, Griffin TZ, Nemesure MD, Price GD, Heinz MV, Nepal S, Pillai A, Mackin DM, Campbell AT, Budney AJ, Jacobson NC
Psychiatry Res. 2024 Sep;339:116110. doi: 10.1016\/j.psychres.2024.116110. Epub 2024 Jul 27.
PMID: 39079375<\/p>

Evaluating preferences for medication formulation and treatment model among people who use opioids non-medically: A web-based cross-sectional study.<\/a>
Saunders EC, Budney AJ, Cavazos-Rehg P, Scherer E, Bell K, John D, Marsch LA
J Subst Use Addict Treat. 2024 Aug;163:209383. doi: 10.1016\/j.josat.2024.209383. Epub 2024 Apr 24.
PMID: 38670531<\/p>

Typical Hits, Grams, or Joints: Evaluating Cannabis Survey Measurement Strategies for Quantifying Consumption.<\/a>
Borodovsky JT, Hasin DS, Shmulewitz D, Walsh C, Livne O, Aharonovich E, Struble CA, Habib MI, Budney AJ
Cannabis Cannabinoid Res. 2024 Apr;9(2):646-658. doi: 10.1089\/can.2022.0237. Epub 2022 Dec 26.
PMID: 36577020<\/p>

Estimating THC Consumption from Smoked and Vaped Cannabis Products in an Online Survey of Adults Who Use Cannabis.<\/a>
Budney AJ, Borodovsky JT, Struble CA, Habib MI, Shmulewitz D, Livne O, Aharonovich E, Walsh C, Cuttler C, Hasin DS
Cannabis Cannabinoid Res. 2024 Apr;9(2):688-698. doi: 10.1089\/can.2022.0238. Epub 2022 Dec 15.
PMID: 36521175<\/p>

Age differences in patterns of cannabis use among an online US sample of adults who consume cannabis frequently.<\/a>
Livne O, Budney A, Borodovsky J, Shmulewitz D, Walsh C, Struble CA, Habib M, Aharonovich E, Hasin DS
Am J Drug Alcohol Abuse. 2024 Mar 3;50(2):242-251. doi: 10.1080\/00952990.2024.2309340. Epub 2024 Apr 19.
PMID: 38640463<\/p>

Biobehavioral and affective stress responses during nicotine withdrawal: Influence of regular cannabis co-use.<\/a>
al'Absi M, DeAngelis BN, Nakajima M, Hodges JS, Budney A, Hatsukami D, Allen S
Psychopharmacology (Berl). 2024 Feb;241(2):253-262. doi: 10.1007\/s00213-023-06481-w. Epub 2023 Oct 28.
PMID: 37897498<\/p>

Development of Mobile Contingency Management for Cannabis Use Reduction.<\/a>
Beckham JC, Calhoun PS, Chen Z, Dennis MF, Kirby AC, Treis ET, Hertzberg JS, Hair LP, Mann AJ, Budney AJ, Kimbrel NA
Behav Ther. 2024 Jan;55(1):1-13. doi: 10.1016\/j.beth.2023.03.004. Epub 2023 Apr 5.
PMID: 38216224<\/p>

Randomized controlled trial of zolpidem as a pharmacotherapy for cannabis use disorder.<\/a>
Lee DC, Schlienz NJ, Herrmann ES, Martin EL, Leoutsakos J, Budney AJ, Smith MT, Tompkins DA, Hampson AJ, Vandrey R
J Subst Use Addict Treat. 2024 Jan;156:209180. doi: 10.1016\/j.josat.2023.209180. Epub 2023 Oct 5.
PMID: 37802317<\/p>

Evaluating age-related disparities in cannabis-related problems among LGBT+\u00a0versus non-LGBT+\u00a0adults.<\/a>
Struble CA, Borodovsky JT, Habib MI, Livne O, Walsh CA, Aharonovich E, Hasin DS, Budney AJ
Addict Behav. 2024 Jan;148:107861. doi: 10.1016\/j.addbeh.2023.107861. Epub 2023 Sep 14.
PMID: 37748224<\/p>

Exploring survey methods for measuring consumption quantities of cannabis flower and concentrate products.<\/a>
Borodovsky JT, Struble CA, Habib MI, Hasin DS, Shmulewitz D, Walsh C, Livne O, Aharonovich E, Budney AJ
Am J Drug Alcohol Abuse. 2023 Nov 2;49(6):733-745. doi: 10.1080\/00952990.2023.2246635. Epub 2023 Dec 11.
PMID: 37774316<\/p>

Daily Cannabis Use Is a Barrier to Tobacco Cessation Among Tobacco Quitline Callers at 7-Month Follow-up.<\/a>
Goodwin RD, Shevorykin A, Carl E, Budney AJ, Rivard C, Wu M, McClure EA, Hyland A, Sheffer CE
Nicotine Tob Res. 2022 Oct 17;24(10):1684-1688. doi: 10.1093\/ntr\/ntac096.
PMID: 35417562<\/p>

Characterizing cannabis use reduction and change in functioning during treatment: Initial steps on the path to new clinical endpoints.<\/a>
Borodovsky JT, Sofis MJ, Sherman BJ, Gray KM, Budney AJ
Psychol Addict Behav. 2022 Aug;36(5):515-525. doi: 10.1037\/adb0000817. Epub 2022 Jan 27.
PMID: 35084903<\/p>

Evaluating cannabis use risk reduction as an alternative clinical outcome for cannabis use disorder.<\/a>
Sherman BJ, Sofis MJ, Borodovsky JT, Gray KM, McRae-Clark AL, Budney AJ
Psychol Addict Behav. 2022 Aug;36(5):505-514. doi: 10.1037\/adb0000760. Epub 2021 Jul 1.
PMID: 34197135<\/p>

Clinical management of cannabis withdrawal.<\/a>
Connor JP, Stjepanovi\u0107 D, Budney AJ, Le Foll B, Hall WD
Addiction. 2022 Jul;117(7):2075-2095. doi: 10.1111\/add.15743. Epub 2022 Jan 10.
PMID: 34791767<\/p>

Is it \"loud\" enough?: A qualitative investigation of blunt use among African American young adults.<\/a>
Montgomery L, Plano Clark VL, Twitty D, Budney AJ, Prochaska JJ, Winhusen T
J Ethn Subst Abuse. 2022 Apr-Jun;21(2):747-761. doi: 10.1080\/15332640.2020.1801548. Epub 2020 Aug 3.
PMID: 32744476<\/p>

Correlates of continued cannabis use during pregnancy.<\/a>
Pike CK, Sofis MJ, Budney AJ
Drug Alcohol Depend. 2021 Oct 1;227:108939. doi: 10.1016\/j.drugalcdep.2021.108939. Epub 2021 Jul 30.
PMID: 34358772<\/p>

Interventions for cannabis use disorder.<\/a>
Winters KC, Mader J, Budney AJ, Stanger C, Knapp AA, Walker DD
Curr Opin Psychol. 2021 Apr;38:67-74. doi: 10.1016\/j.copsyc.2020.11.002. Epub 2020 Nov 17.
PMID: 33338844<\/p>

Cannabis use and cannabis use disorder.<\/a>
Connor JP, Stjepanovi\u0107 D, Le Foll B, Hoch E, Budney AJ, Hall WD
Nat Rev Dis Primers. 2021 Feb 25;7(1):16. doi: 10.1038\/s41572-021-00247-4. Epub 2021 Feb 25.
PMID: 33627670<\/p>

Teen Reports of Cannabis for Medical Reasons-What Does That Mean?<\/a>
Budney AJ
J Adolesc Health. 2021 Jan;68(1):9-10. doi: 10.1016\/j.jadohealth.2020.09.044.
PMID: 33349361<\/p>

The state of clinical outcome assessments for cannabis use disorder clinical trials: A review and research agenda.<\/a>
Loflin MJE, Kiluk BD, Huestis MA, Aklin WM, Budney AJ, Carroll KM, D'Souza DC, Dworkin RH, Gray KM, Hasin DS, Lee DC, Le Foll B, Levin FR, Lile JA, Mason BJ, McRae-Clark AL, Montoya I, Peters EN, Ramey T, Turk DC, Vandrey R, Weiss RD, Strain EC
Drug Alcohol Depend. 2020 Jul 1;212:107993. doi: 10.1016\/j.drugalcdep.2020.107993. Epub 2020 Apr 26.
PMID: 32360455<\/p>

Perceived safety of cannabis intoxication predicts frequency of driving while intoxicated.<\/a>
Borodovsky JT, Marsch LA, Scherer EA, Grucza RA, Hasin DS, Budney AJ
Prev Med. 2020 Feb;131:105956. doi: 10.1016\/j.ypmed.2019.105956. Epub 2019 Dec 19.
PMID: 31863787<\/p>

Working memory training and high magnitude incentives for youth cannabis use: A SMART pilot trial.<\/a>
Stanger C, Scherer EA, Vo HT, Babbin SF, Knapp AA, McKay JR, Budney AJ
Psychol Addict Behav. 2020 Feb;34(1):31-39. doi: 10.1037\/adb0000480. Epub 2019 Jun 27.
PMID: 31246068<\/p>

Emerging Trends in Cannabis Administration Among Adolescent Cannabis Users.<\/a>
Knapp AA, Lee DC, Borodovsky JT, Auty SG, Gabrielli J, Budney AJ
J Adolesc Health. 2019 Apr;64(4):487-493. doi: 10.1016\/j.jadohealth.2018.07.012. Epub 2018 Sep 8.
PMID: 30205931<\/p>

Sequential and simultaneous treatment approaches to cannabis use disorder and tobacco use.<\/a>
Lee DC, Walker DD, Hughes JR, Brunette MF, Scherer E, Stanger C, Etter JF, Auty S, Budney AJ
J Subst Abuse Treat. 2019 Mar;98:39-46. doi: 10.1016\/j.jsat.2018.12.005. Epub 2018 Dec 18.
PMID: 30665602<\/p>

An update on cannabis use disorder with comment on the impact of policy related to therapeutic and recreational cannabis use.<\/a>
Budney AJ, Sofis MJ, Borodovsky JT
Eur Arch Psychiatry Clin Neurosci. 2019 Feb;269(1):73-86. doi: 10.1007\/s00406-018-0976-1. Epub 2019 Jan 2.
PMID: 30604051<\/p>

Cannabis regulatory science: risk-benefit considerations for mental disorders.<\/a>
Borodovsky JT, Budney AJ
Int Rev Psychiatry. 2018 Jun;30(3):183-202. doi: 10.1080\/09540261.2018.1454406. Epub 2018 May 29.
PMID: 29843548<\/p>

Mobile contingency management as an adjunctive treatment for co-morbid cannabis use disorder and cigarette smoking.<\/a>
Beckham JC, Adkisson KA, Hertzberg J, Kimbrel NA, Budney AJ, Stephens RS, Moore SD, Calhoun PS
Addict Behav. 2018 Apr;79:86-92. doi: 10.1016\/j.addbeh.2017.12.007. Epub 2017 Dec 6.
PMID: 29268146<\/p>

The potential impact of cannabis legalization on the development of cannabis use disorders.<\/a>
Budney AJ, Borodovsky JT
Prev Med. 2017 Nov;104:31-36. doi: 10.1016\/j.ypmed.2017.06.034. Epub 2017 Jun 28.
PMID: 28668544<\/p>

U.S. cannabis legalization and use of vaping and edible products among youth.<\/a>
Borodovsky JT, Lee DC, Crosier BS, Gabrielli JL, Sargent JD, Budney AJ
Drug Alcohol Depend. 2017 Aug 1;177:299-306. doi: 10.1016\/j.drugalcdep.2017.02.017. Epub 2017 Jun 9.
PMID: 28662974<\/p>

Abstinence based incentives plus parent training for adolescent alcohol and other substance misuse.<\/a>
Stanger C, Scherer EA, Babbin SF, Ryan SR, Budney AJ
Psychol Addict Behav. 2017 Jun;31(4):385-392. doi: 10.1037\/adb0000279. Epub 2017 Apr 17.
PMID: 28414474<\/p>

Smoking, vaping, eating: Is legalization impacting the way people use cannabis?<\/a>
Borodovsky JT, Crosier BS, Lee DC, Sargent JD, Budney AJ
Int J Drug Policy. 2016 Oct;36:141-7. doi: 10.1016\/j.drugpo.2016.02.022. Epub 2016 Mar 2.
PMID: 26992484<\/p>

Attempts to stop or reduce daily cannabis use: An intensive natural history study.<\/a>
Hughes JR, Naud S, Budney AJ, Fingar JR, Callas PW
Psychol Addict Behav. 2016 May;30(3):389-97. doi: 10.1037\/adb0000155. Epub 2016 Feb 1.
PMID: 26828641<\/p>

Online survey characterizing vaporizer use among cannabis users.<\/a>
Lee DC, Crosier BS, Borodovsky JT, Sargent JD, Budney AJ
Drug Alcohol Depend. 2016 Feb 1;159:227-33. doi: 10.1016\/j.drugalcdep.2015.12.020. Epub 2015 Dec 30.
PMID: 26774946<\/p>

Legal or Illegal, Cannabis Is Still Addictive.<\/a>
Piomelli D, Haney M, Budney AJ, Piazza PV
Cannabis Cannabinoid Res. 2016;1(1):47-53. doi: 10.1089\/can.2015.29004.rtd. Epub 2016 Jan 1.
PMID: 28861480<\/p>

Confirmation of the trials and tribulations of vaping.<\/a>
Budney AJ, Sargent JD, Lee DC
Addiction. 2015 Nov;110(11):1710-1. doi: 10.1111\/add.13155.
PMID: 26471155<\/p>

Vaping cannabis (marijuana): parallel concerns to e-cigs?<\/a>
Budney AJ, Sargent JD, Lee DC
Addiction. 2015 Nov;110(11):1699-704. doi: 10.1111\/add.13036. Epub 2015 Aug 12.
PMID: 26264448<\/p>

Outcomes from a computer-assisted intervention simultaneously targeting cannabis and tobacco use.<\/a>
Lee DC, Budney AJ, Brunette MF, Hughes JR, Etter JF, Stanger C
Drug Alcohol Depend. 2015 Oct 1;155:134-40. doi: 10.1016\/j.drugalcdep.2015.08.001. Epub 2015 Aug 10.
PMID: 26307942<\/p>

Computer-assisted behavioral therapy and contingency management for cannabis use disorder.<\/a>
Budney AJ, Stanger C, Tilford JM, Scherer EB, Brown PC, Li Z, Li Z, Walker DD
Psychol Addict Behav. 2015 Sep;29(3):501-11. doi: 10.1037\/adb0000078. Epub 2015 May 4.
PMID: 25938629<\/p>\n","protected":false},"excerpt":{"rendered":"

The Institute provides a home at Dartmouth for researchers who focus on behavior and non-communicable diseases. We conduct research that has a measurable impact on the risk of these diseases. Cannabis (aka marijuana) — Over the past decade, the prevalence and frequency of cannabis use has increased along with an [\u2026] <\/p>\n

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