{"id":411,"date":"2024-06-19T17:28:04","date_gmt":"2024-06-19T21:28:04","guid":{"rendered":"https:\/\/geiselmed.dartmouth.edu\/huang\/?page_id=411"},"modified":"2026-07-03T11:44:36","modified_gmt":"2026-07-03T15:44:36","slug":"tyler-boone","status":"publish","type":"page","link":"https:\/\/geiselmed.dartmouth.edu\/huang\/lab-members\/tyler-boone\/","title":{"rendered":"Tyler Boone"},"content":{"rendered":"

MCB Graduate Student\u00a0<\/strong><\/p>\n

 <\/p>\n

About Me<\/strong><\/p>\n

\"\"<\/a>I graduated from Wesleyan University in 2021 with two majors and one minor: Molecular Biology and Biochemistry, Biology, and Chemistry respectively. I\u2019ve been enamored by science and the intersection between biology and chemistry since childhood, which led me to pursue four years of undergraduate research investigating topics such as epigenetic silencing and gene regulation. I chose Dartmouth\u2019s MCB program for its breadth and diversity of research opportunities and topics, but ultimately chose immunology as my thesis research. I made this decision despite having never taken an immunology course, but my experience living through a pandemic and learning about the fascinating interplay between cellular and molecular mechanisms in an immunological context motivated me to pursue the research topics in the Huang Lab where I\u2019ve most recently been investigating how\u00a0in vitro<\/i>\u00a0polarization of CAR-T cells can improve their efficacy against solid tumors. Outside of the lab, I enjoy traveling and exploring, playing the piano and guitar, playing video games, and learning about space and quantum physics<\/p>\n

 <\/p>\n

Publications<\/strong><\/p>\n

Mohamed AO, Boone, DT<\/strong>, Ferry SL, Peck MC, Santos AM, Soderholm HE, Wittling MC, Paulos C, Turk MJ, Huang YH. CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors. J Immunother Cancer<\/em> 2025 Feb 11;13(2):e009994. doi: 10.1136\/jitc-2024-009994. PMID: 39933839.<\/p>\n","protected":false},"excerpt":{"rendered":"

MCB Graduate Student\u00a0   About Me I graduated from Wesleyan University in 2021 with two majors and one minor: Molecular Biology and Biochemistry, Biology, and Chemistry respectively. I\u2019ve been enamored by science and the intersection between biology and chemistry since childhood, which led me to pursue four years of undergraduate [\u2026] <\/p>\n

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