{"id":26,"date":"2025-09-09T15:11:22","date_gmt":"2025-09-09T15:11:22","guid":{"rendered":"https:\/\/geiselmed2.dartmouth.edu\/goodrum-lab\/?page_id=26"},"modified":"2025-09-09T15:11:22","modified_gmt":"2025-09-09T15:11:22","slug":"publications","status":"publish","type":"page","link":"https:\/\/geiselmed.dartmouth.edu\/goodrum-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

FEATURED ORIGINAL RESEARCH<\/strong><\/p>\n

Human cytomegalovirus regulates host DNA repair machinery for viral<\/a> genom<\/a>e<\/a> integrity<\/a>. Longmire, P., S. Zeltzer, K. Zarrella, O. Daigle, M. Svoboda, J.M. Reitsma, S.S. Terhune, C. Bobak, G. Bosco, and F. Goodrum<\/strong>. 2025.\u00a0 Nucleic Acids Research<\/em>, in revision.<\/em><\/p>\n

Viral and host network analysis of the human cytomegalovirus transcriptome in latency<\/a>. Collins-McMillen, D., D. De Oliviera-Pessoa, K. Zarrella, N.J. Moorman, J. P. Kamil, P. Caposio, M. Padi, and F.D. Goodrum<\/strong>. 2025.\u00a0 Proc. Natl. Acad. Sci. USA<\/em>,122(22): e2416114122. PMID:40434638<\/a><\/p>\n

Human Cytomegalovirus UL138 Interaction with USP1 Activates STAT1 in Infection<\/a>. Zarrella, K., P. Longmire, S. Zeltzer, D. Collins-McMillen, M. Hancock, J. Buehler, J. Reitsma, J. Nelson, S. S. Terhune, and F. Goodrum<\/strong>. 2023. PLoS Pathogens,<\/em> June 8; 19(6):e1011185. PMID:37289831<\/a><\/p>\n

Host translesion polymerases are required for viral genome integrity<\/a>. Zeltzer, S., P. Longmire, M. Svoboda, G. Bosco, and F. Goodrum<\/strong>. 2022.\u00a0 Proc Natl Acad Sci USA<\/em>, 119(33):e2203203119. PMID: 35947614<\/a><\/p>\n

Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency.<\/a> Buehler, J., E. Carpenter, S. Zeltzer, S. Igarashi, M. Rak, I. Mikell, J.A. Nelson, and F. Goodrum<\/strong>. 2019.\u00a0 PLoS Pathogens<\/em>, 15<\/strong>(11):e1008037. PMID: 31725811<\/a><\/p>\n

Alternative Promoters Drive Human Cytomegalovirus Reactivation from Latency<\/a>. Collins-McMillen, D., M. Rak, J.C. Buehler, S. Igarashi-Hayes, J.P. Kamil, N.J. Moorman, and F. Goodrum<\/strong>. 2019.\u00a0 Proc Natl Acad Sci USA, <\/em>116<\/strong>(35):17492-17497. PMID: 31409717<\/a>.<\/p>\n

Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins to Regulate Epidermal Growth Factor Receptor and Reactivation from Latency<\/a>. Rak, M., J. Buehler, S. Zeltzer, J. Reitsma, S. Terhune, F. Goodrum<\/strong>. 2018.\u00a0 J Virology<\/em>, 92<\/strong>(20): e00919-18. PMID: 30089695<\/a><\/p>\n

Virus control of trafficking from sorting endosomes<\/a>. Zeltzer, S., C. A. Zeltzer, J. Wilson, J. G. Donaldson, and F. Goodrum<\/strong>. 2018. MBio<\/em>, 9<\/strong>(4): e00683-18.<\/em> PMID: 30042195<\/a><\/p>\n

FEATURED REVIEWS<\/strong><\/p>\n

Human cytomegalovirus latency \u2013 the sum of subtleties<\/a>. Hancock, M.H., P. Caposio, D. Collins-McMillen, N.L Diggins, B-.J. Lee, S. Medica, D. N. Streblow, T. White, A.D. Yurochko, F. Goodrum<\/strong>. 2025. J Virology<\/em>, Jul30:e0066425. PMID:40736257<\/a><\/p>\n

Virology \u2013 the next fifty years<\/a>. Holmes, E., F. Krammer, and F. Goodrum<\/strong>. 2024. Cell<\/em>, Sep 19; 187 (19): 5128-5145. PMID:39303682<\/a>\u00a0 PMC11467463<\/p>\n

The complex biology of human cytomegalovirus latency and reactivation.<\/a>\u00a0 Goodrum, F.<\/strong> \u00a02022. In Adv.Virus Res. <\/em>v112. <\/em>Aug 1. PMID:35840181<\/a><\/p>\n

FEATURED SCIENCE ADVOCACY<\/strong><\/p>\n

A call for the United States to continue investing in science.<\/a> Blader, I. \u2020<\/sup>, F. Goodrum<\/strong>\u2020<\/sup>, M.J. Imperiale\u2020<\/sup>, A. Casadevall, C. Arias, A. Baumler, C.A. Burnham, C. Cuomo, C. Detweiler, G. Forrest, J. Gilbert, S. Lovett, S. Maloy, A. McAdam, I. Newton, G. Reguera, G. O\u2019Toole, P. D. Scloss, A. Shade, M. Whiteley. 2025. mBio<\/em>, Apr 9; 16(4)e0064825. Co-published in J Virology<\/em>, J Bacteriology<\/em>, mSphere<\/em>, mSystems<\/em>, Appl. Env. Micro<\/em>., ASM Case Reports<\/em>, Antimicrobial Agents and Chemotherapy<\/em>, J Clin.Microbiol<\/em>., Microbiol Spectrum<\/em>, Clin. Microbiol. Rev<\/em>., Infection and Immunity<\/em>, Microbiol. Resouce Announcements<\/em>, Microbiol. and Mol. Bio. Rev<\/em>., J Microbiol. and Bio. Educ<\/em>. PMID: 40013856<\/a><\/p>\n

The harms of promoting the lab leak hypothesis without evidence.<\/a> Alwine, J.\u2020<\/sup>, Goodrum<\/strong>\u2020<\/sup>, B. Banfield, D. Bloom, W. J. Britt, A. J. Broadbent, S. K. Campos, A. Casadevall, T. Dermody, W. P. Duprex, L. W. Enquist, K. Frueh, M. Gaglia, A.P. Geballe, et al<\/em> (41 authors total)<\/em>. 2024. J Virology<\/em>, 98(9) Sep 17:e0124024. PMID: 39087765<\/a>. Notable press: LA Times<\/em><\/a>, <\/em>TWiV<\/em>,<\/a> STAT<\/em><\/a><\/p>\n

Virology \u2013 the path forward<\/a>. Rasmussen, A. \u2020<\/sup>, G. Gronvall\u2020<\/sup>, A. Lowen\u2020<\/sup>, Goodrum<\/strong>\u2020<\/sup>, et al. (79 total authors<\/em><\/strong>)<\/em>. 2024. J Virology<\/em>, 98(1)Jan 3: e0179123. PMID: 38168672<\/a>\u00a0<\/p>\n

Field research is essential to counter virological threats.<\/a> Runstadler, J. A., A. C. Lowen, G. Kayeli, S. M. Tompkins, R. A. Albrecht, R. A. M. Fouchier, D. E. Stallknecht, S. S. Lakdawala, F. D. Goodrum<\/strong>, A. Casadevall, L. W. Enquist, J. C. Alwine, M. J. Imperiale, S. Schultz-Cherry, R. J. Webby 2023. J. <\/em>Virology<\/em>. doi:10.1128\/jvi.00544-23:e0054423. PMID:37166327<\/a><\/p>\n

A critical analysis of the evidence for the SARS-CoV-2 origin hypotheses<\/a>. Alwine, J.C., A. Casadevall, L.W. Enquist, D. Goodrum\u2020<\/sup><\/strong>, M.J. Imperiale. 2023.\u00a0 Co-published in: mBio, J Virology, mSphere<\/em>. March 28. \u00a0PMID: 36897089<\/a><\/p>\n

Oversight of pathogen research must be carefully calibrated and clearly defined<\/a>. Lowen, A., A. Casadevall, J.C. Alwine, L.W. Enquist, F.D. Goodrum<\/strong>, M.J. Imperiale, S.S. Lakdawala. 2023.\u00a0 Co-published in: mBio, J Virology, <\/em>and mSphere. <\/em>Feb 22. PMID:36811609<\/a>.<\/p>\n

Virology under the microscope \u2013 a call for rational discourse.<\/a> Goodrum, F. \u2020<\/sup><\/strong>, A. Lowen, S. Lakdawala, J. Alwine, A. Casadevall, M. Imperiale, et al.<\/em> (156 total authors<\/em><\/strong>)<\/em>. 2023. Co-published in: mBio, J Virology, <\/em>and 27 Jan. . PMID:\u00a036700640<\/a> Notable press: New York Times<\/em><\/a>, <\/em>NPR<\/em><\/a>, <\/em>Arizona Republic<\/em><\/a>, and <\/em>This Week in Virology (TWiV)<\/em><\/a><\/p>\n

RECENT PUBLICATIONS - PubMed<\/strong><\/p>\n

Human cytomegalovirus regulates host DNA repair machinery for viral genome integrity.<\/a>
Longmire P, Zeltzer S, Zarrella K, Daigle O, Svoboda M, Reitsma JM, et al.
Nucleic Acids Res. 2026 Jan 14;54(2) doi: 10.1093\/nar\/gkaf1445.
PMID: 41533576<\/p>

Human cytomegalovirus promotes de novo PC synthesis during early virus replication.<\/a>
Kline I, Mokry RL, Xi Y, Passols Manzano M, Layesa S, Sohrab Ali N, et al.
J Virol. 2025 Sep 23;99(9):e0057925. doi: 10.1128\/jvi.00579-25. Epub 2025 Aug 19.
PMID: 40827916<\/p>

Cytomegalovirus latency-the sum of subtleties.<\/a>
Hancock MH, Caposio P, Collins-McMillen D, Diggins NL, Lee B-J, Medica S, et al.
J Virol. 2025 Aug 19;99(8):e0066425. doi: 10.1128\/jvi.00664-25. Epub 2025 Jul 30.
PMID: 40736257<\/p>

A call for the United States to continue investing in science.<\/a>
Blader I, Goodrum F, Imperiale MJ, Casadevall A, Arias CA, Baumler A, et al.
Clin Microbiol Rev. 2025 Jun 12;38(2):e0004425. doi: 10.1128\/cmr.00044-25. Epub 2025 Feb 27.
PMID: 40013868<\/p>

Viral and host network analysis of the human cytomegalovirus transcriptome in latency.<\/a>
Collins-McMillen D, De Oliveira Pessoa D, Zarrella K, Parkins CJ, Daily M, McKinzey DR, et al.
Proc Natl Acad Sci U S A. 2025 Jun 3;122(22):e2416114122. doi: 10.1073\/pnas.2416114122. Epub 2025 May 28.
PMID: 40434638<\/p>

Complex roles for proliferating cell nuclear antigen in restricting human cytomegalovirus replication.<\/a>
Longmire P, Daigle O, Zeltzer S, Lee M, Svoboda M, Padilla-Rodriguez M, et al.
mBio. 2025 May 14;16(5):e0045025. doi: 10.1128\/mbio.00450-25. Epub 2025 Mar 25.
PMID: 40130902<\/p>

A call for the United States to continue investing in science.<\/a>
Blader I, Goodrum F, Imperiale MJ, Casadevall A, Arias CA, Baumler A, et al.
Microbiol Spectr. 2025 May 6;13(5):e0056825. doi: 10.1128\/spectrum.00568-25. Epub 2025 Feb 27.
PMID: 40013887<\/p>

A call for the United States to continue investing in science.<\/a>
Blader I, Goodrum F, Imperiale MJ, Casadevall A, Arias CA, Baumler A, et al.
ASM Case Rep. 2025 May;1(3) doi: 10.1128\/asmcr.00043-25. Epub 2025 Feb 27.
PMID: 41246371<\/p>

A call for the United States to continue investing in science.<\/a>
Blader I, Goodrum F, Imperiale MJ, Casadevall A, Arias CA, Baumler A, et al.
J Microbiol Biol Educ. 2025 Apr 24;26(1):e0006725. doi: 10.1128\/jmbe.00067-25. Epub 2025 Feb 27.
PMID: 40013875<\/p>

A call for the United States to continue investing in science.<\/a>
Blader I, Goodrum F, Imperiale MJ, Casadevall A, Arias CA, Baumler A, et al.
Appl Environ Microbiol. 2025 Apr 23;91(4):e0046725. doi: 10.1128\/aem.00467-25. Epub 2025 Feb 27.
PMID: 40013896<\/p>

More on PubMed<\/a>\n","protected":false},"excerpt":{"rendered":"

Human cytomegalovirus promotes de novo PC synthesis during early virus replication.<\/a>
Kline I, Mokry RL, Xi Y, Passols Manzano M, Layesa S, Sohrab Ali N, et al.
J Virol. 2025 Sep 23;99(9):e0057925. doi: 10.1128\/jvi.00579-25. Epub 2025 Aug 19.
PMID: 40827916<\/p>

Viral and host network analysis of the human cytomegalovirus transcriptome in latency.<\/a>
Collins-McMillen D, De Oliveira Pessoa D, Zarrella K, Parkins CJ, Daily M, McKinzey DR, et al.
Proc Natl Acad Sci U S A. 2025 Jun 3;122(22):e2416114122. doi: 10.1073\/pnas.2416114122. Epub 2025 May 28.
PMID: 40434638<\/p>

Human cytomegalovirus promotes de novo PC synthesis during early virus replication.<\/a>
Kline I, Mokry RL, Xi Y, Manzano MP, Layesa S, Ali NS, et al.
bioRxiv. 2025 Mar 6; pii: 2025.03.06.641752. doi: 10.1101\/2025.03.06.641752. Epub 2025 Mar 6.
PMID: 40093147<\/p>
\nMore Publications<\/span><\/a>\u00a0<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-26","page","type-page","status-publish","hentry","author-9"],"_links":{"self":[{"href":"https:\/\/geiselmed.dartmouth.edu\/goodrum-lab\/wp-json\/wp\/v2\/pages\/26","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/geiselmed.dartmouth.edu\/goodrum-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/geiselmed.dartmouth.edu\/goodrum-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/goodrum-lab\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/goodrum-lab\/wp-json\/wp\/v2\/comments?post=26"}],"version-history":[{"count":0,"href":"https:\/\/geiselmed.dartmouth.edu\/goodrum-lab\/wp-json\/wp\/v2\/pages\/26\/revisions"}],"wp:attachment":[{"href":"https:\/\/geiselmed.dartmouth.edu\/goodrum-lab\/wp-json\/wp\/v2\/media?parent=26"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}