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Periannan (Kuppu) Kuppusamy, Ph.D.

Professor of Radiology
Professor of Medicine
Associate Director
EPR Center for Viable Biological Systems


PhD - Indian Institute of Technology (India)
Cardiovascular Fellowship - Johns Hopkins University

EPR Center at Dartmouth Medical School
Heart and Vascular Research Center
Program in Experimental and Molecular Medicine

Contact Information:

EPR Center
48 Lafayette St
Lebanon NH 03766

Phone: 603-650-1034
Fax: 603-643-0304
Email: Periannan.Kuppusamy@Dartmouth.edu

Assistant: Jennifer Thody
Asst. Phone: 603-650-1784
Asst. Email: Jennfer.Thody@Dartmouth.edu

Professional Interests:

Oxygen, oximetry, oxygenomics
Cancer & Cardiovascular disease/therapy
EPR, Imaging, clinical oximetry

Selected Publications:


Avtanski DB, Nagalingam A, Kuppusamy P, Bonner MY, Arbiser JL, Saxena NK, Sharma D
Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-β-catenin signaling axis in a microRNA-34a dependent manner.
Oncotarget 2015 Apr 15;
PMID: 26036628

Hashem M, Weiler-Sagie M, Kuppusamy P, Neufeld G, Neeman M, Blank A
Electron spin resonance microscopic imaging of oxygen concentration in cancer spheroids.
J Magn Reson 2015 Jul; 256:77-85
PMID: 26022394

Kuppusamy P, Yusoff MM, Parine NR, Govindan N
Evaluation of in-vitro antioxidant and antibacterial properties of Commelina nudiflora L. extracts prepared by different polar solvents.
Saudi J Biol Sci 2015 May; 22(3):293-301
PMID: 25972750

Kuppusamy P, Ichwan SJ, Parine NR, Yusoff MM, Maniam GP, Govindan N
Intracellular biosynthesis of Au and Ag nanoparticles using ethanolic extract of Brassica oleracea L. and studies on their physicochemical and biological properties.
J Environ Sci (China) 2015 Mar 1; 29:151-7
PMID: 25766024

Khan N, Hou H, Eskey CJ, Moodie K, Gohain S, Du G, Hodge S, Culp WC, Kuppusamy P, Swartz HM
Deep-tissue oxygen monitoring in the brain of rabbits for stroke research.
Stroke 2015 Mar; 46(3):e62-6
PMID: 25613304

McCann GA, Naidu S, Rath KS, Bid HK, Tierney BJ, Suarez A, Varadharaj S, Zhang J, Hideg K, Houghton P, Kuppusamy P, Cohn DE, Selvendiran K
Targeting constitutively-activated STAT3 in hypoxic ovarian cancer, using a novel STAT3 inhibitor.
Oncoscience 2014; 1(3):216-28
PMID: 25594014

Citro L, Naidu S, Hassan F, Kuppusamy ML, Kuppusamy P, Angelos MG, Khan M
Comparison of human induced pluripotent stem-cell derived cardiomyocytes with human mesenchymal stem cells following acute myocardial infarction.
PLoS One 2014; 9(12):e116281
PMID: 25551230

Tierney BJ, McCann GA, Naidu S, Rath KS, Saini U, Wanner R, Kuppusamy P, Suarez A, Goodfellow PJ, Cohn DE, Selvendiran K
Aberrantly activated pSTAT3-Ser727 in human endometrial cancer is suppressed by HO-3867, a novel STAT3 inhibitor.
Gynecol Oncol 2014 Oct; 135(1):133-41
PMID: 25038288

Nagalingam A, Kuppusamy P, Singh SV, Sharma D, Saxena NK
Mechanistic elucidation of the antitumor properties of withaferin a in breast cancer.
Cancer Res 2014 May 1; 74(9):2617-29
PMID: 24732433

Khan N, Hou H, Hodge S, Kuppusamy M, Chen EY, Eastman A, Kuppusamy P, Swartz HM
Recurrent low-dose chemotherapy to inhibit and oxygenate head and neck tumors.
Adv Exp Med Biol 2014; 812:105-11
PMID: 24729221