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Periannan (Kuppu) Kuppusamy, Ph.D.

Professor of Radiology
Professor of Medicine
Associate Director
EPR Center for Viable Biological Systems


PhD - Indian Institute of Technology (India)
Cardiovascular Fellowship - Johns Hopkins University

EPR Center at Dartmouth Medical School
Heart and Vascular Research Center
Program in Experimental and Molecular Medicine

Contact Information:

EPR Center
48 Lafayette St
Lebanon NH 03766

Phone: 603-650-1034
Fax: 603-643-0304
Email: Periannan.Kuppusamy@Dartmouth.edu

Assistant: Jennifer Thody
Asst. Phone: 603-650-1784
Asst. Email: Jennfer.Thody@Dartmouth.edu

Professional Interests:

Oxygen, oximetry, oxygenomics
Cancer & Cardiovascular disease/therapy
EPR, Imaging, clinical oximetry

Selected Publications:


Kuppusamy P, Yusoff MM, Parine NR, Govindan N
Evaluation of in-vitro antioxidant and antibacterial properties of Commelina nudiflora L. extracts prepared by different polar solvents.
Saudi J Biol Sci 2015 May; 22(3):293-301
PMID: 25972750

Kuppusamy P, Ichwan SJ, Parine NR, Yusoff MM, Maniam GP, Govindan N
Intracellular biosynthesis of Au and Ag nanoparticles using ethanolic extract of Brassica oleracea L. and studies on their physicochemical and biological properties.
J Environ Sci (China) 2015 Mar 1; 29:151-7
PMID: 25766024

Khan N, Hou H, Eskey CJ, Moodie K, Gohain S, Du G, Hodge S, Culp WC, Kuppusamy P, Swartz HM
Deep-tissue oxygen monitoring in the brain of rabbits for stroke research.
Stroke 2015 Mar; 46(3):e62-6
PMID: 25613304

McCann GA, Naidu S, Rath KS, Bid HK, Tierney BJ, Suarez A, Varadharaj S, Zhang J, Hideg K, Houghton P, Kuppusamy P, Cohn DE, Selvendiran K
Targeting constitutively-activated STAT3 in hypoxic ovarian cancer, using a novel STAT3 inhibitor.
Oncoscience 2014; 1(3):216-28
PMID: 25594014

Citro L, Naidu S, Hassan F, Kuppusamy ML, Kuppusamy P, Angelos MG, Khan M
Comparison of human induced pluripotent stem-cell derived cardiomyocytes with human mesenchymal stem cells following acute myocardial infarction.
PLoS One 2014; 9(12):e116281
PMID: 25551230

Tierney BJ, McCann GA, Naidu S, Rath KS, Saini U, Wanner R, Kuppusamy P, Suarez A, Goodfellow PJ, Cohn DE, Selvendiran K
Aberrantly activated pSTAT3-Ser727 in human endometrial cancer is suppressed by HO-3867, a novel STAT3 inhibitor.
Gynecol Oncol 2014 Oct; 135(1):133-41
PMID: 25038288

Nagalingam A, Kuppusamy P, Singh SV, Sharma D, Saxena NK
Mechanistic elucidation of the antitumor properties of withaferin a in breast cancer.
Cancer Res 2014 May 1; 74(9):2617-29
PMID: 24732433

Khan N, Hou H, Hodge S, Kuppusamy M, Chen EY, Eastman A, Kuppusamy P, Swartz HM
Recurrent low-dose chemotherapy to inhibit and oxygenate head and neck tumors.
Adv Exp Med Biol 2014; 812:105-11
PMID: 24729221

Hou H, Khan N, Lariviere J, Hodge S, Chen EY, Jarvis LA, Eastman A, Williams BB, Kuppusamy P, Swartz HM
Skeletal muscle and glioma oxygenation by carbogen inhalation in rats: a longitudinal study by EPR oximetry using single-probe implantable oxygen sensors.
Adv Exp Med Biol 2014; 812:97-103
PMID: 24729220

Rivera BK, Naidu SK, Subramanian K, Joseph M, Hou H, Khan N, Swartz HM, Kuppusamy P
Real-time, in vivo determination of dynamic changes in lung and heart tissue oxygenation using EPR oximetry.
Adv Exp Med Biol 2014; 812:81-6
PMID: 24729218