Alix Ashare, MD, PhD
Title(s)
Associate Professor of Medicine
Associate Professor of Microbiology and Immunology
Department(s)
Medicine
Microbiology and Immunology
Education
Vanderbilt University School of Medicine, MD 1999
University of Iowa College of Medicine, PhD 2008
Programs
Molecular and Cellular Biology Graduate Programs
Websites
https:
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Contact Information
1 Medical Center Dr
Lebanon NH 03756
Office: 508E Borwell
Phone: 603-650-5533
Fax: 603-650-0580
Email: Alix.Ashare@dartmouth.edu
Professional Interests
My research focuses on the role of lung macrophages in the development of inflammatory lung diseases. Currently my laboratory is investigating the potential mechanisms of increased lung inflammation in patients with cystic fibrosis (CF) and asthma, with an emphasis on the investigation of impaired alveolar macrophage function in the patient populations.
A major focus of my laboratory is the investigation of how the metabolic state of lung macrophages impacts their phenotype and function and how these changes in the immune cell may contribute to chronic inflammation in CF and asthma. We are also interested in how new medication aimed at treating the underlying defect in CF impact macrophage populations. We are currently funded by the Cystic Fibrosis Foundation to investigate the metabolic state and inflammatory profile of macrophages isolated from CF patients treated with highly effective modulator therapy. Another area of focus involves studying the interaction between bacterial pathogens and host innate immune cells in the CF lung.
Rotations and Thesis Projects
Project 1: One potential project involves looking at the effects of outer membrane vesicles released by bacteria on the inflammatory response of human macrophages. This project will compare different strains of bacteria as well as treatment with various antibiotics to investigate the impact on the macrophage inflammatory response.
Project 2: This project involves looking at the effect of chronic e-cigarette exposure on lipid homeostasis in lung macrophages.
Grant Information
Macrophage Pathogen Interactions in Regional CF Lung Inflammation (NIH/NHLBI)
The Impact of CFTR Modulator Treatment on CF Lung Macrophage Inflammation (CF Foundation)
The Role of Lung Macrophage Metabolic State in CF Lung Inflammation (CF Foundation)
Courses Taught
CF: From Bedside and Bench, and Back Again
Scientific Basis of Medicine: Respiratory Section
Biography
Dr. Ashare received her B.S. from Vanderbilt University in 1994, her M.D. from Vanderbilt University School of Medicine in 1999, and her Ph.D. in Translational Biomedicine from the University of Iowa in 2008. Following Medical School, she completed an Internal Medicine Residency and Pulmonary & Critical Care Fellowship at the University of Iowa Hospitals and Clinics in 2002 and 2005, respectively. In 2005, she joined the faculty at the University of Iowa. She moved her clinical and research program to Dartmouth in 2009.
P. aeruginosa tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis. P. aeruginosa tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis. Characterization of SARS-CoV-2 Convalescent Patients' Serological Repertoire Reveals High Prevalence of Iso-RBD Antibodies. Comparative effects of CFTR modulators on phagocytic, metabolic and inflammatory profiles of CF and nonCF macrophages. Mrs4 loss of function in fungi during adaptation to the cystic fibrosis lung. Mrs4 loss of function in fungi during adaptation to the cystic fibrosis lung. The Impact of Chronic Electronic Cigarette Use on Alveolar Macrophage Lipid Content: Case Report. ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALF. Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa variant. Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions. |
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