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Brent L Berwin, Ph.D.

Associate Professor of Microbiology and Immunology

Microbiology and Immunology

University of Wisconsin-Madison, Ph.D., 1999
Lewis & Clark College, B.S., 1991

Dr. Berwin graduated from the University of Wisconsin-Madison in 1999. He did his postdoc training at Duke University and joined Dartmouth Medical School in the fall of 2004. Dr. Berwin is an Associate Professor in the Department of Microbiology and Immunology.

Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center


Contact Information:

Dartmouth Medical Center
1 Medical Center Dr.
HB 7556 - Rm. 614W
Lebanon NH 03756

Phone: 603-650-6899
Fax: 603-650-6223
Email: berwin@dartmouth.edu

Selected Publications:


Monomethylarsonous Acid (MMAIII) Has an Adverse Effect on the Innate Immune Response of Human Bronchial Epithelial Cells to Pseudomonas aeruginosa.
Notch EG, Goodale BC, Barnaby R, Coutermarsh B, Berwin B, Taylor VF, Jackson BP, Stanton BA
PLoS One. 2015;10(11):e0142392. doi: 10.1371/journal.pone.0142392. Epub 2015 Nov 10.
PMID: 26554712

Differential ASC requirements reveal a key role for neutrophils and a noncanonical IL-1β response to Pseudomonas aeruginosa.
Patankar YR, Mabaera R, Berwin B
Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15;309(8):L902-13. doi: 10.1152/ajplung.00228.2015. Epub 2015 Aug 21.
PMID: 26472815

Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance.
Blazanovic K, Zhao H, Choi Y, Li W, Salvat RS, Osipovitch DC, Fields J, Moise L, Berwin BL, Fiering SN, Bailey-Kellogg C, Griswold KE
Mol Ther Methods Clin Dev. 2015;2:15021. doi: 10.1038/mtm.2015.21. Epub 2015 Jun 17.
PMID: 26151066

Myeloid derived hypoxia inducible factor 1-alpha is required for protection against pulmonary Aspergillus fumigatus infection.
Shepardson KM, Jhingran A, Caffrey A, Obar JJ, Suratt BT, Berwin BL, Hohl TM, Cramer RA
PLoS Pathog. 2014 Sep;10(9):e1004378. doi: 10.1371/journal.ppat.1004378. Epub 2014 Sep 25.
PMID: 25255025

Acidosis potentiates the host proinflammatory interleukin-1β response to Pseudomonas aeruginosa infection.
Torres IM, Patankar YR, Shabaneh TB, Dolben E, Hogan DA, Leib DA, Berwin BL
Infect Immun. 2014 Nov;82(11):4689-97. doi: 10.1128/IAI.02024-14. Epub 2014 Aug 25.
PMID: 25156732

CX3CR1 delineates temporally and functionally distinct subsets of myeloid-derived suppressor cells in a mouse model of ovarian cancer.
Hart KM, Usherwood EJ, Berwin BL
Immunol Cell Biol. 2014 Jul;92(6):499-508. doi: 10.1038/icb.2014.13. Epub 2014 Mar 11.
PMID: 24613975

Pseudomonas aeruginosa flagellar motility activates the phagocyte PI3K/Akt pathway to induce phagocytic engulfment.
Lovewell RR, Hayes SM, O'Toole GA, Berwin B
Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306(7):L698-707. doi: 10.1152/ajplung.00319.2013. Epub 2014 Jan 31.
PMID: 24487390

Mechanisms of phagocytosis and host clearance of Pseudomonas aeruginosa.
Lovewell RR, Patankar YR, Berwin B
Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306(7):L591-603. doi: 10.1152/ajplung.00335.2013. Epub 2014 Jan 24.
PMID: 24464809

Acat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis.
Huang LH, Gui J, Artinger E, Craig R, Berwin BL, Ernst PA, Chang CC, Chang TY
Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2081-7. doi: 10.1161/ATVBAHA.112.301080. Epub 2013 Jul 11.
PMID: 23846496

Flagellar motility is a key determinant of the magnitude of the inflammasome response to Pseudomonas aeruginosa.
Patankar YR, Lovewell RR, Poynter ME, Jyot J, Kazmierczak BI, Berwin B
Infect Immun. 2013 Jun;81(6):2043-52. doi: 10.1128/IAI.00054-13. Epub 2013 Mar 25.
PMID: 23529619