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Henry N. Higgs, PhD

Title(s)
Professor of Biochemistry and Cell Biology
John La Porte Given Foundation, Inc. Professorship in Cytology

Department(s)
Biochemistry and Cell Biology

Education
Lafayette College, BA 1987U. Washington, PHD 1996

Programs
Molecular and Cellular Biology Graduate Programs

Academic Analytics
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Contact Information

Dartmouth Medical School
HB 7200
Hanover NH 03755


Professional Interests

Microvilli cover the surface of circulating blood lymphocytes. Lymphocytes use these finger-like projections to segregate adhesion receptors, as certain receptors localize to microvilli while others are excluded from them. Adhesion receptor segregation is crucial because cells use these receptors sequentially when moving from the bloodsteam to specific tissues. Little is known about the architecture of microvilli, nor about their relationship to similar structures from other cells. My lab will identify protein components crucial to microvillar structure, test how mutation of these proteins affect microvillar structure and function, and characterize how these proteins function biochemically and biophysically.


Selected Publications

 

Effects of phosphorylation on Drp1 activation by its receptors, actin, and cardiolipin.
Liu A, Hatch AL, Higgs HN
Mol Biol Cell. 2024 Feb 1;35(2):ar16. doi: 10.1091/mbc.E23-11-0427. Epub 2023 Nov 29.
PMID: 38019609

Effects of phosphorylation on Drp1 activation by its receptors, actin, and cardiolipin.
Liu A, Hatch AL, Higgs HN
bioRxiv. 2023 Aug 20; pii: 2023.08.20.554022. doi: 10.1101/2023.08.20.554022. Epub 2023 Aug 20.
PMID: 37645886

Publisher Correction: The multiple links between actin and mitochondria.
Fung TS, Chakrabarti R, Higgs HN
Nat Rev Mol Cell Biol. 2023 Sep;24(9):688. doi: 10.1038/s41580-023-00632-9.
PMID: 37380675

The multiple links between actin and mitochondria.
Fung TS, Chakrabarti R, Higgs HN
Nat Rev Mol Cell Biol. 2023 Sep;24(9):651-667. doi: 10.1038/s41580-023-00613-y. Epub 2023 Jun 5.
PMID: 37277471

Acute ACAT1/SOAT1 Blockade Increases MAM Cholesterol and Strengthens ER-Mitochondria Connectivity.
Harned TC, Stan RV, Cao Z, Chakrabarti R, Higgs HN, Chang CCY, Chang TY
Int J Mol Sci. 2023 Mar 14;24(6) doi: 10.3390/ijms24065525. Epub 2023 Mar 14.
PMID: 36982602

Mitochondrial dysfunction triggers actin polymerization necessary for rapid glycolytic activation.
Chakrabarti R, Fung TS, Kang T, Elonkirjo PW, Suomalainen A, Usherwood EJ, Higgs HN
J Cell Biol. 2022 Nov 7;221(11) doi: 10.1083/jcb.202201160. Epub 2022 Sep 14.
PMID: 36102863

Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division.
Kage F, Vicente-Manzanares M, McEwan BC, Kettenbach AN, Higgs HN
Mol Biol Cell. 2022 Jun 1;33(7):ar63. doi: 10.1091/mbc.E22-01-0005. Epub 2022 Apr 15.
PMID: 35427150

Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria.
Fung TS, Chakrabarti R, Kollasser J, Rottner K, Stradal TEB, Kage F, Higgs HN
Curr Biol. 2022 Apr 11;32(7):1577-1592.e8. doi: 10.1016/j.cub.2022.02.058. Epub 2022 Mar 14.
PMID: 35290799

Mff oligomerization is required for Drp1 activation and synergy with actin filaments during mitochondrial division.
Liu A, Kage F, Higgs HN
Mol Biol Cell. 2021 Oct 1;32(20):ar5. doi: 10.1091/mbc.E21-04-0224. Epub 2021 Aug 4.
PMID: 34347505

Multiple roles for actin in secretory and endocytic pathways.
Chakrabarti R, Lee M, Higgs HN
Curr Biol. 2021 May 24;31(10):R603-R618. doi: 10.1016/j.cub.2021.03.038.
PMID: 34033793

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