Henry N. Higgs, PhD
Title(s)
Professor of Biochemistry and Cell Biology
John La Porte Given Foundation, Inc. Professorship in Cytology
Department(s)
Biochemistry and Cell Biology
Education
Lafayette College, BA 1987U. Washington, PHD 1996
Programs
Molecular and Cellular Biology Graduate Programs
Contact Information
Dartmouth Medical School
HB 7200
Hanover NH 03755
Professional Interests
Microvilli cover the surface of circulating blood lymphocytes. Lymphocytes use these finger-like projections to segregate adhesion receptors, as certain receptors localize to microvilli while others are excluded from them. Adhesion receptor segregation is crucial because cells use these receptors sequentially when moving from the bloodsteam to specific tissues. Little is known about the architecture of microvilli, nor about their relationship to similar structures from other cells. My lab will identify protein components crucial to microvillar structure, test how mutation of these proteins affect microvillar structure and function, and characterize how these proteins function biochemically and biophysically.
Mitochondrial fission - changing perspectives for future progress. INF2 mutations cause kidney disease through a gain-of-function mechanism. Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51. Effects of phosphorylation on Drp1 activation by its receptors, actin, and cardiolipin. Effects of phosphorylation on Drp1 activation by its receptors, actin, and cardiolipin. Publisher Correction: The multiple links between actin and mitochondria. The multiple links between actin and mitochondria. Acute ACAT1/SOAT1 Blockade Increases MAM Cholesterol and Strengthens ER-Mitochondria Connectivity. Mitochondrial dysfunction triggers actin polymerization necessary for rapid glycolytic activation. Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division. |
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