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Henry N. Higgs, PhD

Title(s):
Professor of Biochemistry & Cell Biology

Department(s):
Biochemistry & Cell Biology

Education:
Lafayette College, BA 1987U. Washington, PHD 1996

Programs:
Molecular and Cellular Biology Graduate Programs

Contact Information:

Dartmouth Medical School
HB 7200
Hanover NH 03755


Professional Interests:

Microvilli cover the surface of circulating blood lymphocytes. Lymphocytes use these finger-like projections to segregate adhesion receptors, as certain receptors localize to microvilli while others are excluded from them. Adhesion receptor segregation is crucial because cells use these receptors sequentially when moving from the bloodsteam to specific tissues. Little is known about the architecture of microvilli, nor about their relationship to similar structures from other cells. My lab will identify protein components crucial to microvillar structure, test how mutation of these proteins affect microvillar structure and function, and characterize how these proteins function biochemically and biophysically.


Selected Publications:

 

Two distinct actin filament populations have effects on mitochondria, with differences in stimuli and assembly factors.
Fung TS, Ji WK, Higgs HN, Chakrabarti R
J Cell Sci. 2019 Sep 23;132(18) pii: jcs234435. doi: 10.1242/jcs.234435. Epub 2019 Sep 23.
PMID: 31413070

A complex containing lysine-acetylated actin inhibits the formin INF2.
A M, Fung TS, Kettenbach AN, Chakrabarti R, Higgs HN
Nat Cell Biol. 2019 May;21(5):592-602. doi: 10.1038/s41556-019-0307-4. Epub 2019 Apr 8.
PMID: 30962575

The Pollard lab at Salk: moving the leading edge forward.
Higgs HN
Biophys Rev. 2018 Dec;10(6):1487-1490. doi: 10.1007/s12551-018-0480-x. Epub 2018 Nov 12.
PMID: 30421275

Roles for Ena/VASP proteins in FMNL3-mediated filopodial assembly.
Young LE, Latario CJ, Higgs HN
J Cell Sci. 2018 Oct 29;131(21) pii: jcs220814. doi: 10.1242/jcs.220814. Epub 2018 Oct 29.
PMID: 30373894

Long-Term Potentiation Requires a Rapid Burst of Dendritic Mitochondrial Fission during Induction.
Divakaruni SS, Van Dyke AM, Chandra R, LeGates TA, Contreras M, Dharmasri PA, Higgs HN, Lobo MK, Thompson SM, Blanpied TA
Neuron. 2018 Nov 21;100(4):860-875.e7. doi: 10.1016/j.neuron.2018.09.025. Epub 2018 Oct 11.
PMID: 30318410

Focal Adhesions Undergo Longitudinal Splitting into Fixed-Width Units.
Young LE, Higgs HN
Curr Biol. 2018 Jul 9;28(13):2033-2045.e5. doi: 10.1016/j.cub.2018.04.073. Epub 2018 Jun 14.
PMID: 29910076

Receptor-mediated Drp1 oligomerization on endoplasmic reticulum.
Ji WK, Chakrabarti R, Fan X, Schoenfeld L, Strack S, Higgs HN
J Cell Biol. 2017 Dec 4;216(12):4123-4139. doi: 10.1083/jcb.201610057. Epub 2017 Nov 20.
PMID: 29158231

INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division.
Chakrabarti R, Ji WK, Stan RV, de Juan Sanz J, Ryan TA, Higgs HN
J Cell Biol. 2018 Jan 2;217(1):251-268. doi: 10.1083/jcb.201709111. Epub 2017 Nov 15.
PMID: 29142021

Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes.
Fritz-Laylin LK, Riel-Mehan M, Chen BC, Lord SJ, Goddard TD, Ferrin TE, Nicholson-Dykstra SM, Higgs H, Johnson GT, Betzig E, Mullins RD
Elife. 2017 Sep 26;6 pii: e26990. doi: 10.7554/eLife.26990. Epub 2017 Sep 26.
PMID: 28948912

Function-Oriented Studies Targeting Pectenotoxin 2: Synthesis of the GH-Ring System and a Structurally Simplified Macrolactone.
O'Rourke NF, A M, Higgs HN, Eastman A, Micalizio GC
Org Lett. 2017 Oct 6;19(19):5154-5157. doi: 10.1021/acs.orglett.7b02435. Epub 2017 Sep 13.
PMID: 28901150

View more publications on PubMed