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Henry N. Higgs, PhD

Professor of Biochemistry and Cell Biology

Biochemistry and Cell Biology

Lafayette College, BA 1987U. Washington, PHD 1996

Molecular and Cellular Biology Graduate Programs

Contact Information:

Dartmouth Medical School
HB 7200
Hanover NH 03755

Professional Interests:

Microvilli cover the surface of circulating blood lymphocytes. Lymphocytes use these finger-like projections to segregate adhesion receptors, as certain receptors localize to microvilli while others are excluded from them. Adhesion receptor segregation is crucial because cells use these receptors sequentially when moving from the bloodsteam to specific tissues. Little is known about the architecture of microvilli, nor about their relationship to similar structures from other cells. My lab will identify protein components crucial to microvillar structure, test how mutation of these proteins affect microvillar structure and function, and characterize how these proteins function biochemically and biophysically.

Selected Publications:


Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner.
Latario CJ, Schoenfeld LW, Howarth CL, Pickrell LE, Begum F, Fischer DA, Grbovic-Huezo O, Leach SD, Sanchez Y, Smith KD, Higgs HN
Mol Biol Cell. 2020 Jun 1;31(12):1259-1272. doi: 10.1091/mbc.E19-11-0605. Epub 2020 Apr 8.
PMID: 32267199

FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes.
Subramanian B, Chun J, Perez-Gill C, Yan P, Stillman IE, Higgs HN, Alper SL, Schlondorff JS, Pollak MR
J Am Soc Nephrol. 2020 Feb;31(2):374-391. doi: 10.1681/ASN.2019050443. Epub 2020 Jan 10.
PMID: 31924668

Regulation of INF2-mediated actin polymerization through site-specific lysine acetylation of actin itself.
A M, Fung TS, Francomacaro LM, Huynh T, Kotila T, Svindrych Z, Higgs HN
Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):439-447. doi: 10.1073/pnas.1914072117. Epub 2019 Dec 23.
PMID: 31871199

Two distinct actin filament populations have effects on mitochondria, with differences in stimuli and assembly factors.
Fung TS, Ji WK, Higgs HN, Chakrabarti R
J Cell Sci. 2019 Sep 23;132(18) pii: jcs234435. doi: 10.1242/jcs.234435. Epub 2019 Sep 23.
PMID: 31413070

A complex containing lysine-acetylated actin inhibits the formin INF2.
A M, Fung TS, Kettenbach AN, Chakrabarti R, Higgs HN
Nat Cell Biol. 2019 May;21(5):592-602. doi: 10.1038/s41556-019-0307-4. Epub 2019 Apr 8.
PMID: 30962575

The Pollard lab at Salk: moving the leading edge forward.
Higgs HN
Biophys Rev. 2018 Dec;10(6):1487-1490. doi: 10.1007/s12551-018-0480-x. Epub 2018 Nov 12.
PMID: 30421275

Roles for Ena/VASP proteins in FMNL3-mediated filopodial assembly.
Young LE, Latario CJ, Higgs HN
J Cell Sci. 2018 Oct 29;131(21) pii: jcs220814. doi: 10.1242/jcs.220814. Epub 2018 Oct 29.
PMID: 30373894

Long-Term Potentiation Requires a Rapid Burst of Dendritic Mitochondrial Fission during Induction.
Divakaruni SS, Van Dyke AM, Chandra R, LeGates TA, Contreras M, Dharmasri PA, Higgs HN, Lobo MK, Thompson SM, Blanpied TA
Neuron. 2018 Nov 21;100(4):860-875.e7. doi: 10.1016/j.neuron.2018.09.025. Epub 2018 Oct 11.
PMID: 30318410

Focal Adhesions Undergo Longitudinal Splitting into Fixed-Width Units.
Young LE, Higgs HN
Curr Biol. 2018 Jul 9;28(13):2033-2045.e5. doi: 10.1016/j.cub.2018.04.073. Epub 2018 Jun 14.
PMID: 29910076

Receptor-mediated Drp1 oligomerization on endoplasmic reticulum.
Ji WK, Chakrabarti R, Fan X, Schoenfeld L, Strack S, Higgs HN
J Cell Biol. 2017 Dec 4;216(12):4123-4139. doi: 10.1083/jcb.201610057. Epub 2017 Nov 20.
PMID: 29158231

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