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Henry N. Higgs, PhD

Title(s)
Professor of Biochemistry and Cell Biology
John La Porte Given Foundation, Inc. Professorship in Cytology

Department(s)
Biochemistry and Cell Biology

Education
Lafayette College, BA 1987U. Washington, PHD 1996

Programs
Molecular and Cellular Biology Graduate Programs

Contact Information

Dartmouth Medical School
HB 7200
Hanover NH 03755


Professional Interests

Microvilli cover the surface of circulating blood lymphocytes. Lymphocytes use these finger-like projections to segregate adhesion receptors, as certain receptors localize to microvilli while others are excluded from them. Adhesion receptor segregation is crucial because cells use these receptors sequentially when moving from the bloodsteam to specific tissues. Little is known about the architecture of microvilli, nor about their relationship to similar structures from other cells. My lab will identify protein components crucial to microvillar structure, test how mutation of these proteins affect microvillar structure and function, and characterize how these proteins function biochemically and biophysically.


Selected Publications

 

Mitochondrial dysfunction triggers actin polymerization necessary for rapid glycolytic activation.
Chakrabarti R, Fung TS, Kang T, Elonkirjo PW, Suomalainen A, Usherwood EJ, Higgs HN
J Cell Biol. 2022 Nov 7;221(11) pii: e202201160. doi: 10.1083/jcb.202201160. Epub 2022 Sep 14.
PMID: 36102863

Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division.
Kage F, Vicente-Manzanares M, McEwan BC, Kettenbach AN, Higgs HN
Mol Biol Cell. 2022 Jun 1;33(7):ar63. doi: 10.1091/mbc.E22-01-0005. Epub 2022 Apr 15.
PMID: 35427150

Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria.
Fung TS, Chakrabarti R, Kollasser J, Rottner K, Stradal TEB, Kage F, Higgs HN
Curr Biol. 2022 Apr 11;32(7):1577-1592.e8. doi: 10.1016/j.cub.2022.02.058. Epub 2022 Mar 14.
PMID: 35290799

Mff oligomerization is required for Drp1 activation and synergy with actin filaments during mitochondrial division.
Liu A, Kage F, Higgs HN
Mol Biol Cell. 2021 Oct 1;32(20):ar5. doi: 10.1091/mbc.E21-04-0224. Epub 2021 Aug 4.
PMID: 34347505

Multiple roles for actin in secretory and endocytic pathways.
Chakrabarti R, Lee M, Higgs HN
Curr Biol. 2021 May 24;31(10):R603-R618. doi: 10.1016/j.cub.2021.03.038.
PMID: 34033793

SEC24A facilitates colocalization and Ca2+ flux between the endoplasmic reticulum and mitochondria.
Chidawanyika T, Chakrabarti R, Beauchemin KS, Higgs HN, Supattapone S
J Cell Sci. 2021 Mar 26;134(6) pii: jcs249276. doi: 10.1242/jcs.249276. Epub 2021 Mar 26.
PMID: 33622772

Lysine acetylation of cytoskeletal proteins: Emergence of an actin code.
A M, Latario CJ, Pickrell LE, Higgs HN
J Cell Biol. 2020 Dec 7;219(12) pii: e202006151. doi: 10.1083/jcb.202006151.
PMID: 33044556

Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner.
Latario CJ, Schoenfeld LW, Howarth CL, Pickrell LE, Begum F, Fischer DA, Grbovic-Huezo O, Leach SD, Sanchez Y, Smith KD, Higgs HN
Mol Biol Cell. 2020 Jun 1;31(12):1259-1272. doi: 10.1091/mbc.E19-11-0605. Epub 2020 Apr 8.
PMID: 32267199

FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes.
Subramanian B, Chun J, Perez-Gill C, Yan P, Stillman IE, Higgs HN, Alper SL, Schlondorff JS, Pollak MR
J Am Soc Nephrol. 2020 Feb;31(2):374-391. doi: 10.1681/ASN.2019050443. Epub 2020 Jan 10.
PMID: 31924668

Regulation of INF2-mediated actin polymerization through site-specific lysine acetylation of actin itself.
A M, Fung TS, Francomacaro LM, Huynh T, Kotila T, Svindrych Z, Higgs HN
Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):439-447. doi: 10.1073/pnas.1914072117. Epub 2019 Dec 23.
PMID: 31871199

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