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Duane A. Compton, PhD

Professor of Biochemistry and Cell Biology
Dean of the Medical School

Biochemistry and Cell Biology

U. Oklahoma, BS 1984
U. Texas, PHD 1988

Academy of Master Faculty Educators
Molecular and Cellular Biology Graduate Programs


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Contact Information

Geisel School of Medicine at Dartmouth
HB 7200
Hanover NH 03755

Professional Interests

Work in this lab is aimed at understanding how chromosomes segregate efficiently during mitosis and meiosis in vertebrate cells. Using both in vitro and in vivo approaches, the assembly and function of the microtubule-based spindle is being dissected at the molecular level. This work has led to the characterization of both structural and motor proteins that are necessary for the organization of the microtubules into spindles during mitosis and meiosis. Current work is aimed at how this process is regulated during the cell cycle and at how these proteins coordinate chromosome movement during cell division.

Mentoring Information

Duane would be happy to mentor faculty about teaching in large or small group environments, directing a course, and mentoring graduate students.


Duane has contributed lectures and small group discussions to Biochem 110, the Biochemical and Genetic Basis of Medicine, for first year medical students. He served as course director for Biochem 110 for many years. Duane also contributed lectures to Biochem 103, the third term of the MCB core course for first year graduate students. He served as course director for that course for many years. Duane has mentored 13 graduate students to the completion of their PhDs.

Selected Publications


Cyclin A/Cdk1 promotes chromosome alignment and timely mitotic progression.
Valles SY, Godek KM, Compton DA
bioRxiv. 2023 Dec 21; pii: 2023.12.21.572788. doi: 10.1101/2023.12.21.572788. Epub 2023 Dec 21.
PMID: 38187612

An Aurora kinase A-BOD1L1-PP2A B56 Axis promotes chromosome segregation fidelity.
Kucharski TJ, Vlasac IM, Higgs MR, Christensen BC, Bechstedt S, Compton DA
bioRxiv. 2024 Mar 6; pii: 2023.08.06.552174. doi: 10.1101/2023.08.06.552174. Epub 2024 Mar 6.
PMID: 37609141

A pluripotent developmental state confers a low fidelity of chromosome segregation.
Deng C, Ya A, Compton DA, Godek KM
Stem Cell Reports. 2023 Feb 14;18(2):475-488. doi: 10.1016/j.stemcr.2022.12.008. Epub 2023 Jan 12.
PMID: 36638786

Small changes in phospho-occupancy at the kinetochore-microtubule interface drive mitotic fidelity.
Kucharski TJ, Hards R, Vandal SE, Abad MA, Jeyaprakash AA, Kaye E, Al-Rawi A, Ly T, Godek KM, Gerber SA, Compton DA
J Cell Biol. 2022 Sep 5;221(9) doi: 10.1083/jcb.202107107. Epub 2022 Jul 25.
PMID: 35878017

Identifying Cyclin A/Cdk1 Substrates in Mitosis in Human Cells.
Dumitru AMG, Compton DA
Methods Mol Biol. 2022;2415:175-182. doi: 10.1007/978-1-0716-1904-9_13.
PMID: 34972954

A comparative analysis of methods to measure kinetochore-microtubule attachment stability.
Warren JD, Orr B, Compton DA
Methods Cell Biol. 2020;158:91-116. doi: 10.1016/bs.mcb.2020.01.004. Epub 2020 Feb 24.
PMID: 32423652

Chromosomal instability suppresses the growth of K-Ras-induced lung adenomas.
Laucius CD, Orr B, Compton DA
Cell Cycle. 2019 Aug;18(15):1702-1713. doi: 10.1080/15384101.2019.1629790. Epub 2019 Jun 24.
PMID: 31179849

Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells.
Zhao Y, Carter R, Natarajan S, Varn FS, Compton DA, Gawad C, Cheng C, Godek KM
BMC Med Genomics. 2019 May 31;12(1):79. doi: 10.1186/s12920-019-0532-5. Epub 2019 May 31.
PMID: 31151460

Quantitative methods to measure aneuploidy and chromosomal instability.
Godek KM, Compton DA
Methods Cell Biol. 2018;144:15-32. doi: 10.1016/bs.mcb.2018.03.002. Epub 2018 Apr 24.
PMID: 29804667

Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability.
Dumitru AMG, Rusin SF, Clark AEM, Kettenbach AN, Compton DA
Elife. 2017 Nov 20;6 doi: 10.7554/eLife.29303. Epub 2017 Nov 20.
PMID: 29154753

View more publications on PubMed