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Duane A. Compton, PhD

Title(s)
Professor of Biochemistry and Cell Biology
Dean of the Medical School

Department(s)
Biochemistry and Cell Biology

Education
U. Oklahoma, BS 1984
U. Texas, PHD 1988

Programs
Academy of Master Faculty Educators
Molecular and Cellular Biology Graduate Programs

Websites
http://geiselmed.dartmouth.edu/compton/

Contact Information

Geisel School of Medicine at Dartmouth
HB 7200
Hanover NH 03755


Professional Interests

Work in this lab is aimed at understanding how chromosomes segregate efficiently during mitosis and meiosis in vertebrate cells. Using both in vitro and in vivo approaches, the assembly and function of the microtubule-based spindle is being dissected at the molecular level. This work has led to the characterization of both structural and motor proteins that are necessary for the organization of the microtubules into spindles during mitosis and meiosis. Current work is aimed at how this process is regulated during the cell cycle and at how these proteins coordinate chromosome movement during cell division.

Biography

Duane has contributed lectures and small group discussions to Biochem 110, the Biochemical and Genetic Basis of Medicine, for first year medical students. He served as course director for Biochem 110 for many years. Duane also contributed lectures to Biochem 103, the third term of the MCB core course for first year graduate students. He served as course director for that course for many years. Duane has mentored 13 graduate students to the completion of their PhDs.

Mentoring Information

Duane would be happy to mentor faculty about teaching in large or small group environments, directing a course, and mentoring graduate students.


Selected Publications

 

Identifying Cyclin A/Cdk1 Substrates in Mitosis in Human Cells.
Dumitru AMG, Compton DA
Methods Mol Biol. 2022;2415:175-182. doi: 10.1007/978-1-0716-1904-9_13.
PMID: 34972954

A comparative analysis of methods to measure kinetochore-microtubule attachment stability.
Warren JD, Orr B, Compton DA
Methods Cell Biol. 2020;158:91-116. doi: 10.1016/bs.mcb.2020.01.004. Epub 2020 Feb 24.
PMID: 32423652

Chromosomal instability suppresses the growth of K-Ras-induced lung adenomas.
Laucius CD, Orr B, Compton DA
Cell Cycle. 2019 Aug;18(15):1702-1713. doi: 10.1080/15384101.2019.1629790. Epub 2019 Jun 24.
PMID: 31179849

Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells.
Zhao Y, Carter R, Natarajan S, Varn FS, Compton DA, Gawad C, Cheng C, Godek KM
BMC Med Genomics. 2019 May 31;12(1):79. doi: 10.1186/s12920-019-0532-5. Epub 2019 May 31.
PMID: 31151460

Quantitative methods to measure aneuploidy and chromosomal instability.
Godek KM, Compton DA
Methods Cell Biol. 2018;144:15-32. doi: 10.1016/bs.mcb.2018.03.002. Epub 2018 Apr 24.
PMID: 29804667

Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability.
Dumitru AMG, Rusin SF, Clark AEM, Kettenbach AN, Compton DA
Elife. 2017 Nov 20;6 pii: e29303. doi: 10.7554/eLife.29303. Epub 2017 Nov 20.
PMID: 29154753

Mitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities.
Bakhoum SF, Kabeche L, Compton DA, Powell SN, Bastians H
Trends Cancer. 2017 Mar;3(3):225-234. doi: 10.1016/j.trecan.2017.02.001. Epub 2017 Feb 28.
PMID: 28718433

Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells.
Orr B, Talje L, Liu Z, Kwok BH, Compton DA
Cell Rep. 2016 Nov 8;17(7):1755-1763. doi: 10.1016/j.celrep.2016.10.030.
PMID: 27829147

Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2.
Danilov AV, Hu S, Orr B, Godek K, Mustachio LM, Sekula D, Liu X, Kawakami M, Johnson FM, Compton DA, Freemantle SJ, Dmitrovsky E
Mol Cancer Ther. 2016 Nov;15(11):2758-2766. Epub 2016 Aug 22.
PMID: 27550941

Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells.
Godek KM, Venere M, Wu Q, Mills KD, Hickey WF, Rich JN, Compton DA
Cancer Discov. 2016 May;6(5):532-45. doi: 10.1158/2159-8290.CD-15-1154. Epub 2016 Mar 21.
PMID: 27001151

View more publications on PubMed