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Duane A. Compton, PhD

Title(s):
Professor of Biochemistry & Cell Biology
Dean of the Medical School

Department(s):
Biochemistry & Cell Biology

Education:
U. Oklahoma, BS 1984
U. Texas, PHD 1988

Programs:
Academy of Master Faculty Educators
Molecular and Cellular Biology Graduate Programs

Websites:
http://geiselmed.dartmouth.edu/compton/

Contact Information:

Geisel School of Medicine at Dartmouth
HB 7200
Hanover NH 03755


Professional Interests:

Work in this lab is aimed at understanding how chromosomes segregate efficiently during mitosis and meiosis in vertebrate cells. Using both in vitro and in vivo approaches, the assembly and function of the microtubule-based spindle is being dissected at the molecular level. This work has led to the characterization of both structural and motor proteins that are necessary for the organization of the microtubules into spindles during mitosis and meiosis. Current work is aimed at how this process is regulated during the cell cycle and at how these proteins coordinate chromosome movement during cell division.

Biography:

Duane has contributed lectures and small group discussions to Biochem 110, the Biochemical and Genetic Basis of Medicine, for first year medical students. He served as course director for Biochem 110 for many years. Duane also contributed lectures to Biochem 103, the third term of the MCB core course for first year graduate students. He served as course director for that course for many years. Duane has mentored 13 graduate students to the completion of their PhDs.

Mentoring Information:

Duane would be happy to mentor faculty about teaching in large or small group environments, directing a course, and mentoring graduate students.


Selected Publications:

 

Chromosomal Instability Suppresses the Growth of K-Ras-induced Lung Adenomas.
Laucius CD, Orr B, Compton DA
Cell Cycle. 2019 Jun 10; doi: 10.1080/15384101.2019.1629790. Epub 2019 Jun 10.
PMID: 31179849

Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells.
Zhao Y, Carter R, Natarajan S, Varn FS, Compton DA, Gawad C, Cheng C, Godek KM
BMC Med Genomics. 2019 May 31;12(1):79. doi: 10.1186/s12920-019-0532-5. Epub 2019 May 31.
PMID: 31151460

Quantitative methods to measure aneuploidy and chromosomal instability.
Godek KM, Compton DA
Methods Cell Biol. 2018;144:15-32. doi: 10.1016/bs.mcb.2018.03.002. Epub 2018 Apr 24.
PMID: 29804667

Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability.
Dumitru AMG, Rusin SF, Clark AEM, Kettenbach AN, Compton DA
Elife. 2017 Nov 20;6 pii: e29303. doi: 10.7554/eLife.29303. Epub 2017 Nov 20.
PMID: 29154753

Mitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities.
Bakhoum SF, Kabeche L, Compton DA, Powell SN, Bastians H
Trends Cancer. 2017 Mar;3(3):225-234. doi: 10.1016/j.trecan.2017.02.001. Epub 2017 Feb 28.
PMID: 28718433

Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells.
Orr B, Talje L, Liu Z, Kwok BH, Compton DA
Cell Rep. 2016 Nov 8;17(7):1755-1763. doi: 10.1016/j.celrep.2016.10.030.
PMID: 27829147

Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2.
Danilov AV, Hu S, Orr B, Godek K, Mustachio LM, Sekula D, Liu X, Kawakami M, Johnson FM, Compton DA, Freemantle SJ, Dmitrovsky E
Mol Cancer Ther. 2016 Nov;15(11):2758-2766. Epub 2016 Aug 22.
PMID: 27550941

Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells.
Godek KM, Venere M, Wu Q, Mills KD, Hickey WF, Rich JN, Compton DA
Cancer Discov. 2016 May;6(5):532-45. doi: 10.1158/2159-8290.CD-15-1154. Epub 2016 Mar 21.
PMID: 27001151

Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2.
Kim JS, He X, Orr B, Wutz G, Hill V, Peters JM, Compton DA, Waldman T
PLoS Genet. 2016 Feb;12(2):e1005865. doi: 10.1371/journal.pgen.1005865. Epub 2016 Feb 12.
PMID: 26871722

Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.
Hu S, Lu Y, Orr B, Godek K, Mustachio LM, Kawakami M, Sekula D, Compton DA, Freemantle S, Dmitrovsky E
Mol Cancer Ther. 2015 Nov;14(11):2576-85. doi: 10.1158/1535-7163.MCT-15-0443. Epub 2015 Aug 24.
PMID: 26304236

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