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Daniel A Alexander, PhD

Title(s)
Assistant Professor of Radiation Oncology and Applied Sciences

Additional Titles/Positions/Affiliations
Adjunct Assistant Professor of Engineering, Thayer School of Engineering
Associate Program Director, Medical Physics Residency

Department(s)
Radiation Oncology and Applied Sciences

Education
BS Physics, Rensselaer Polytechnic Institute
MS Physics, Rensselaer Polytechnic Institute
PhD Medical Physics, Dartmouth College
Residency, Therapeutic Medical Physics, University of Pennsylvania

Programs
Dartmouth Cancer Center

Websites
https://geiselmed.dartmouth.edu/roas/profile/alexander-daniel/

Contact Information

Radiation Oncology
Dartmouth-Hitchcock Medical Center
1 Medical Center Drive
Lebanon NH 03756

Email: Daniel.A.Alexander@dartmouth.edu


Professional Interests

Artificial Intelligence in Radiation Oncology, Cherenkov Imaging, Scintillator Imaging, Brachytherapy


Selected Publications

 

Evaluating the dosimetric impact of intrafraction shifts on critical OAR doses for spine SBRT using an In-House simulator.
Alexander DA, Scheuermann R, Messing I, Kassaee A, Hubley E, Koger B, Anamalayil S, Hassankhani A, Freeman CW, Malhotra N, Peters GW, Butala AA
Tech Innov Patient Support Radiat Oncol. 2026 Mar;37:100378. doi: 10.1016/j.tipsro.2026.100378. Epub 2026 Jan 8.
PMID: 41583860

Correction: Innovative approaches in precision radiation oncology: advanced imaging technologies and challenges which shape the future of radiation therapy.
Yan Y, Alexander DA, Bednarz BP, Bronk LF, Chen H, Gladstone DJ, Han B, Iannuzzi CM, Li Y, Nguyen N, Mulenga N, Viscariello NN, Wang Y, Weygand J, Zlateva Y, Guan F
Front Med (Lausanne). 2025;12:1738811. doi: 10.3389/fmed.2025.1738811. Epub 2025 Nov 25.
PMID: 41377801

Innovative approaches in precision radiation oncology: advanced imaging technologies and challenges which shape the future of radiation therapy.
Yan Y, Alexander DA, Bednarz BP, Bronk LF, Chen H, Gladstone DJ, Han B, Iannuzzi CM, Li Y, Nguyen N, Mulenga N, Viscariello NN, Wang Y, Weygand J, Zlateva Y, Guan F
Front Med (Lausanne). 2025;12:1686593. doi: 10.3389/fmed.2025.1686593. Epub 2025 Oct 30.
PMID: 41244760

Improving Cherenkov-based radiotherapy dose estimates in diverse patient populations via skin luminance imaging.
Decker SM, Andreozzi JM, Hernandez D, Alexander DA, Wickramasinghe V, Hachadorian RL, Oraiqat IM, Chen E, Washington IR, Gui J, Zhang R, Jarvis LA, Bruza P, Gladstone DJ, Pogue BW
Phys Med Biol. 2025 Jul 29;70(15) doi: 10.1088/1361-6560/aded68. Epub 2025 Jul 29.
PMID: 40628285

Characterization of Cherenkov imaging parameters and positional constraints on an O-ring linear accelerator.
Alexander DA, Majji S, Jermyn M, Byrd BK, Bruza P, Li T, Zhu TC
Phys Med Biol. 2023 Oct 13;68(20) doi: 10.1088/1361-6560/acfdf2. Epub 2023 Oct 13.
PMID: 37757840

Color-resolved Cherenkov imaging allows for differential signal detection in blood and melanin content.
Wickramasinghe VA, Decker SM, Streeter SS, Sloop AM, Petusseau AF, Alexander DA, Bruza P, Gladstone DJ, Zhang R, Pogue BW
J Biomed Opt. 2023 Mar;28(3):036005. doi: 10.1117/1.JBO.28.3.036005. Epub 2023 Mar 13.
PMID: 36923987

Fast Deformable Image Registration for Real-Time Target Tracking During Radiation Therapy Using Cine MRI and Deep Learning.
Hunt B, Gill GS, Alexander DA, Streeter SS, Gladstone DJ, Russo GA, Zaki BI, Pogue BW, Zhang R
Int J Radiat Oncol Biol Phys. 2023 Mar 15;115(4):983-993. doi: 10.1016/j.ijrobp.2022.09.086. Epub 2022 Oct 26.
PMID: 36309075

Clinical implementation of the first Cherenkov imaging system in a community-based hospital.
Chen E, Pogue BW, Bruza P, Alexander DA, Andino NL, Decker SM, Gaudet DM, Gladstone DJ, Lake MJ, Levene SR, Michelson JL, Robinson HL, Stallings DN, Starkey JE, Jarvis LA
Tech Innov Patient Support Radiat Oncol. 2022 Dec;24:1-5. doi: 10.1016/j.tipsro.2022.08.011. Epub 2022 Sep 9.
PMID: 36118989

Performance comparison of quantitative metrics for analysis of in vivo Cherenkov imaging incident detection during radiotherapy.
Decker SM, Alexander DA, Bruza P, Zhang R, Chen E, Jarvis LA, Gladstone DJ, Pogue BW
Br J Radiol. 2022 Sep 1;95(1137):20211346. doi: 10.1259/bjr.20211346. Epub 2022 Jul 27.
PMID: 35834415

One Year of Clinic-Wide Cherenkov Imaging for Discovery of Quality Improvement Opportunities in Radiation Therapy.
Alexander DA, Decker SM, Jermyn M, Bruza P, Zhang R, Chen E, McGlynn TL, Rosselot RA, Lee J, Rose ML, Williams BB, Pogue BW, Gladstone DJ, Jarvis LA
Pract Radiat Oncol. 2023 Jan-Feb;13(1):71-81. doi: 10.1016/j.prro.2022.06.009. Epub 2022 Jun 29.
PMID: 35777728

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