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Mark Sundrud, PhD

Title(s)
Professor of Medicine
Professor of Microbiology and Immunology

Additional Titles/Positions/Affiliations
Principal Investigator, Dartmouth Health

Department(s)
Medicine
Microbiology and Immunology

Education
Ph.D., Vanderbilt University Medical Center (Microbiology & Immunology)
B.A., Concordia College (Biology, Psychology
Chemistry)

Programs
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center

Curriculum Vitae
Sundrud_M_CV_2022-09-27.pdf

Contact Information

Borwell Research Building, HB7999
1 Medical Center Drive
Lebanon NH 03756

Office: Borwell 630W
Phone: 6036507812
Email: Mark.Sundrud@Dartmouth.edu


Professional Interests

Intestinal immune regulation; gastrointestinal physiology; development and function of effector and regulatory T cells; bile acids; nuclear receptors; inflammatory bowel disease

Rotations and Thesis Projects

Nuclear receptor networks in intestinal T cell development and function; T cell redox metabolism; gut microbe-bile acid-T cell interplay'; region-specific immune regulatory networks in the intestine; immune and bile acid dysregulation in IBD; bile acid-directed IBD therapies.

Grant Information

NIH R01 5R01AI143821, “Determinants of bile acid-dependent T cell regulation in the intestine" (PI); 1 R01 AI164772-01, “Nuclear receptor control of T cell function in discrete intestinal microenvironments” (PI); 1 U01 AI163063-01, “Nuclear Receptor Networks in Mucosal Immune Regulation” (PI); 1 R21 AI154039-01A1, “Transcript-selective translational control of Th17 cell development and function” (PI)

Biography

A native of Minnesota, Dr. Sundrud received his Ph.D. in Cellular and Molecular Immunology from Vanderbilt University, and performed post-doctoral training at Harvard Medical School as an Irvington Institute fellow of the Cancer Research Institute (CRI). After his postdoc, Dr. Sundrud spent 3 years leading Discovery Biology research at Tempero Pharmaceuticals, a GSK-funded start-up biotech company located in Cambridge, MA. Dr. Sundrud was recruited to join the Faculty of The Scripps Research Institute’s Jupiter, Florida (Scripps Florida) campus as an Assistant Professor in 2013. He was promoted to Full Professor (with Tenure) in January 2022, and joined Dartmouth Health and Geisel School of Medicine at Dartmouth College in September 2022. Dr. Sundrud’s work focuses broadly on identifying, and ultimately manipulating, novel pathways underlying T cell-driven inflammatory diseases. His lab has been consistently funded by the National Institutes of Health (NIH) and the Crohn’s and Colitis Foundation (CCF) to interrogate novel mechanisms by which xenobiotic-sensing nuclear receptors and transporters mediate crosstalk between T cells and bile acids in the small intestine.

Mentoring Information

Dr. Sundrud is a passionate advocate for increasing diversity, equity and inclusion (DEI) in the life and biomedical sciences. He has worked in both formal and informal settings throughout his career to increase access to undergraduate research opportunities, particularly for low-income, rural, first-generation college and URM students. Dr. Sundrud's experience in both the Academic and Industry research sectors affords his students and trainees with unique perspectives on the skills and insights needed to pursue careers in either arena.


Selected Publications

 

Development of a putative Zn(2+)-chelating but highly selective MMP-13 inhibitor.
Fuerst R, Choi JY, Knapinska AM, Cameron MD, Ruiz C, Delmas A, Sundrud MS, Fields GB, Roush WR
Bioorg Med Chem Lett. 2022 Nov 15;76:129014. doi: 10.1016/j.bmcl.2022.129014. Epub 2022 Oct 4.
PMID: 36202189

Transcriptional Behavior of Regulatory T Cells Predicts IBD Patient Responses to Vedolizumab Therapy.
Abreu MT, Davies JM, Quintero MA, Delmas A, Diaz S, Martinez CD, Venables T, Reich A, Crynen G, Deshpande AR, Kerman DH, Damas OM, Fernandez I, Santander AM, Pignac-Kobinger J, Burgueno JF, Sundrud MS
Inflamm Bowel Dis. 2022 Dec 1;28(12):1800-1812. doi: 10.1093/ibd/izac151.
PMID: 35993552

CAR directs T cell adaptation to bile acids in the small intestine.
Chen ML, Huang X, Wang H, Hegner C, Liu Y, Shang J, Eliason A, Diao H, Park H, Frey B, Wang G, Mosure SA, Solt LA, Kojetin DJ, Rodriguez-Palacios A, Schady DA, Weaver CT, Pipkin ME, Moore DD, Sundrud MS
Nature. 2021 May;593(7857):147-151. doi: 10.1038/s41586-021-03421-6. Epub 2021 Apr 7.
PMID: 33828301

Regulation of Intestinal Inflammation by Dietary Fats.
Basson AR, Chen C, Sagl F, Trotter A, Bederman I, Gomez-Nguyen A, Sundrud MS, Ilic S, Cominelli F, Rodriguez-Palacios A
Front Immunol. 2020;11:604989. doi: 10.3389/fimmu.2020.604989. Epub 2021 Feb 2.
PMID: 33603741

Genetic and pharmacological inhibition of the nuclear receptor RORα regulates T(H)17 driven inflammatory disorders.
Wang R, Campbell S, Amir M, Mosure SA, Bassette MA, Eliason A, Sundrud MS, Kamenecka TM, Solt LA
Nat Commun. 2021 Jan 4;12(1):76. doi: 10.1038/s41467-020-20385-9. Epub 2021 Jan 4.
PMID: 33397953

Physiological expression and function of the MDR1 transporter in cytotoxic T lymphocytes.
Chen ML, Sun A, Cao W, Eliason A, Mendez KM, Getzler AJ, Tsuda S, Diao H, Mukori C, Bruno NE, Kim SY, Pipkin ME, Koralov SB, Sundrud MS
J Exp Med. 2020 May 4;217(5) doi: 10.1084/jem.20191388.
PMID: 32302378

Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
Kim Y, Sundrud MS, Zhou C, Edenius M, Zocco D, Powers K, Zhang M, Mazitschek R, Rao A, Yeo CY, Noss EH, Brenner MB, Whitman M, Keller TL
Proc Natl Acad Sci U S A. 2020 Apr 21;117(16):8900-8911. doi: 10.1073/pnas.1913788117. Epub 2020 Apr 6.
PMID: 32253314

Artificial microbiome heterogeneity spurs six practical action themes and examples to increase study power-driven reproducibility.
Basson AR, LaSalla A, Lam G, Kulpins D, Moen EL, Sundrud MS, Miyoshi J, Ilic S, Theriault BR, Cominelli F, Rodriguez-Palacios A
Sci Rep. 2020 Mar 19;10(1):5039. doi: 10.1038/s41598-020-60900-y. Epub 2020 Mar 19.
PMID: 32193395

The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.
Cao W, Kayama H, Chen ML, Delmas A, Sun A, Kim SY, Rangarajan ES, McKevitt K, Beck AP, Jackson CB, Crynen G, Oikonomopoulos A, Lacey PN, Martinez GJ, Izard T, Lorenz RG, Rodriguez-Palacios A, Cominelli F, Abreu MT, Hommes DW, Koralov SB, Takeda K, Sundrud MS
Immunity. 2020 Mar 17;52(3):571. doi: 10.1016/j.immuni.2020.01.019.
PMID: 32187521

Emerging roles of bile acids in mucosal immunity and inflammation.
Chen ML, Takeda K, Sundrud MS
Mucosal Immunol. 2019 Jul;12(4):851-861. doi: 10.1038/s41385-019-0162-4. Epub 2019 Apr 5.
PMID: 30952999

View more publications on PubMed