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Sladjana Skopelja-Gardner, PhD

Title(s)
Assistant Professor of Medicine
Assistant Professor of Microbiology and Immunology

Department(s)
Medicine
Microbiology and Immunology

Education
Geisel School of Medicine at Dartmouth, Ph.D., 2017
Dartmouth College, B.A., 2011

Programs
Molecular and Cellular Biology Graduate Programs

Websites
https://geiselmed.dartmouth.edu/sg-lab/

Academic Analytics
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Contact Information

One Medical Center Dr
Borwell 608W
Lebanon NH 03756

Email: Sladjana.Skopelja-Gardner@Dartmouth.edu


Professional Interests

Our research aims to identify how innate immune pathways drive the development of autoimmunity and contribute to disease pathogenesis. We are addressing these questions in models of skin sterile inflammation that are relevant to autoimmune diseases such as systemic lupus erythematosus (SLE) and dermatomyositis (DM), as well as in primary human tissues. With the goal to identify novel therapeutic targets, we are investigating the regulation of type I interferon response as well as neutrophil migration and function.


Selected Publications

 

Role of the cGAS-STING pathway in systemic and organ-specific diseases.
Skopelja-Gardner S, An J, Elkon KB
Nat Rev Nephrol. 2022 Sep;18(9):558-572. doi: 10.1038/s41581-022-00589-6. Epub 2022 Jun 22.
PMID: 35732833

Differential Enhancement of Neutrophil Phagocytosis by Anti-Bactericidal/Permeability-Increasing Protein Antibodies.
Theprungsirikul J, Skopelja-Gardner S, Wierzbicki RM, Sessions KJ, Rigby WFC
J Immunol. 2021 Aug 1;207(3):777-783. doi: 10.4049/jimmunol.2100378. Epub 2021 Jul 16.
PMID: 34272233

Killing three birds with one BPI: Bactericidal, opsonic, and anti-inflammatory functions.
Theprungsirikul J, Skopelja-Gardner S, Rigby WFC
J Transl Autoimmun. 2021;4:100105. doi: 10.1016/j.jtauto.2021.100105. Epub 2021 May 28.
PMID: 34142075

Bactericidal/Permeability-Increasing Protein Preeminently Mediates Clearance of Pseudomonas aeruginosa In Vivo via CD18-Dependent Phagocytosis.
Theprungsirikul J, Skopelja-Gardner S, Burns AS, Wierzbicki RM, Rigby WFC
Front Immunol. 2021;12:659523. doi: 10.3389/fimmu.2021.659523. Epub 2021 Apr 26.
PMID: 33981306

Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation.
Skopelja-Gardner S, Tai J, Sun X, Tanaka L, Kuchenbecker JA, Snyder JM, Kubes P, Mustelin T, Elkon KB
Proc Natl Acad Sci U S A. 2021 Jan 19;118(3) doi: 10.1073/pnas.2019097118.
PMID: 33397815

The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent.
Skopelja-Gardner S, An J, Tai J, Tanaka L, Sun X, Hermanson P, Baum R, Kawasumi M, Green R, Gale M Jr, Kalus A, Werth VP, Elkon KB
Sci Rep. 2020 May 13;10(1):7908. doi: 10.1038/s41598-020-64865-w. Epub 2020 May 13.
PMID: 32404939

Complement Deficiencies Result in Surrogate Pathways of Complement Activation in Novel Polygenic Lupus-like Models of Kidney Injury.
Skopelja-Gardner S, Colonna L, Hermanson P, Sun X, Tanaka L, Tai J, Nguyen Y, Snyder JM, Alpers CE, Hudkins KL, Salant DJ, Peng Y, Elkon KB
J Immunol. 2020 May 15;204(10):2627-2640. doi: 10.4049/jimmunol.1901473. Epub 2020 Apr 1.
PMID: 32238460

Regulation of Pseudomonas aeruginosa-Mediated Neutrophil Extracellular Traps.
Skopelja-Gardner S, Theprungsirikul J, Lewis KA, Hammond JH, Carlson KM, Hazlett HF, Nymon A, Nguyen D, Berwin BL, Hogan DA, Rigby WFC
Front Immunol. 2019;10:1670. doi: 10.3389/fimmu.2019.01670. Epub 2019 Jul 18.
PMID: 31379861

Autoimmunity to bactericidal/permeability-increasing protein in bronchiectasis exhibits a requirement for Pseudomonas aeruginosa IgG response.
Skopelja-Gardner S, Theprungsirikul J, Meagher RE, Beliveau CM, Bradley KE, Avery M, Henkle E, Siegel S, Gifford AH, Winthrop KL, Rigby WFC
Eur Respir J. 2019 Feb;53(2) pii: 1801891. doi: 10.1183/13993003.01891-2018. Epub 2019 Feb 7.
PMID: 30385530

"NETtling" the host: Breaking of tolerance in chronic inflammation and chronic infection.
Skopelja-Gardner S, Jones JD, Rigby WFC
J Autoimmun. 2018 Mar;88:1-10. doi: 10.1016/j.jaut.2017.10.008.
PMID: 29100671

View more publications on PubMed