Sladjana Skopelja-Gardner, PhD
Title(s)
Assistant Professor of Medicine
Assistant Professor of Processing
Department(s)
Medicine
Processing
Education
Geisel School of Medicine at Dartmouth, Ph.D., 2017
Dartmouth College, B.A., 2011
Programs
Molecular and Cellular Biology Graduate Programs
Websites
https:
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Contact Information
One Medical Center Dr
Borwell 608W
Lebanon NH 03756
Professional Interests
Our research aims to identify how innate immune pathways drive the development of autoimmunity and contribute to disease pathogenesis. We are addressing these questions in models of skin sterile inflammation that are relevant to autoimmune diseases such as systemic lupus erythematosus (SLE) and dermatomyositis (DM), as well as in primary human tissues. With the goal to identify novel therapeutic targets, we are investigating the regulation of type I interferon response as well as neutrophil migration and function.
Immune complex-driven neutrophil activation and BAFF release: a link to B cell responses in SLE. Role of the cGAS-STING pathway in systemic and organ-specific diseases. Differential Enhancement of Neutrophil Phagocytosis by Anti-Bactericidal/Permeability-Increasing Protein Antibodies. Killing three birds with one BPI: Bactericidal, opsonic, and anti-inflammatory functions. Bactericidal/Permeability-Increasing Protein Preeminently Mediates Clearance of Pseudomonas aeruginosa In Vivo via CD18-Dependent Phagocytosis. Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation. The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent. Complement Deficiencies Result in Surrogate Pathways of Complement Activation in Novel Polygenic Lupus-like Models of Kidney Injury. Regulation of Pseudomonas aeruginosa-Mediated Neutrophil Extracellular Traps. Autoimmunity to bactericidal/permeability-increasing protein in bronchiectasis exhibits a requirement for Pseudomonas aeruginosa IgG response. |
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