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Lucas A Salas, MD, MPH, PhD

Title(s):
Assistant Professor of Epidemiology

Additional Titles/Positions/Affiliations:
Investigator Cancer Population Sciences Research Program, Dartmouth Hitchcock- Norris Cotton Cancer Center

Department(s):
Epidemiology

Education:
Universitat Pompeu Fabra, PhD 2015
Universitat Pompeu Fabra, MPH 2011
Universidad de Antioquia, Epidemiology 2007
Universidad Nacional de Colombia, MD 2001

Programs:
Quantitative Biomedical Sciences

NIH Biosketch:
Salas_L_BIO_2020-09-21.pdf

Websites:
http://salas-lab.com/
https://orcid.org/0000-0002-2279-4097
https://scholar.google.com/citations?user=FsRf5lQAAAAJ&hl=en
https://publons.com/researcher/1222796/lucas-a-salas/
https://bioconductor.org/packages/release/data/experiment/html/FlowSorted.Blood.EPIC.html
https://bioconductor.org/packages/release/data/experiment/html/FlowSorted.CordBloodCombined.450k.html

Contact Information:


Professional Interests:

The broad goal of Dr. Salas research is to investigate how cell heterogeneity impact human health and disease, with an emphasis on how genetic, environmental and lifestyle factors model the human epigenome and therefore the cell plasticity. Dr. Salas’ laboratory studies how some key epigenetic mechanisms (DNA methylation, DNA hydroxymethylation and miRNA alterations) affect gene expression and cancer outcomes, including how the immune cells are altered in this disease. Other research interests include biomarker development, chronic inflammation and human disease, and how exposures during fetal life alter newborn and childhood outcomes.

Courses Taught:

PEMM.103
MDED.118
QBS.271


Selected Publications:

 

DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies.
Vehmeijer FOL, Kupers LK, Sharp GC, Salas LA, Lent S, Jima DD, Tindula G, Reese S, Qi C, Gruzieva O, Page C, Rezwan FI, Melton PE, Nohr E, Escaramis G, Rzehak P, Heiskala A, Gong T, Tuominen ST, Gao L, Ross JP, Starling AP, Holloway JW, Yousefi P, Aasvang GM, Beilin LJ, Bergstrom A, Binder E, Chatzi L, Corpeleijn E, Czamara D, Eskenazi B, Ewart S, Ferre N, Grote V, Gruszfeld D, Haberg SE, Hoyo C, Huen K, Karlsson R, Kull I, Langhendries JP, Lepeule J, Magnus MC, Maguire RL, Molloy PL, Monnereau C, Mori TA, Oken E, Raikkonen K, Rifas-Shiman S, Ruiz-Arenas C, Sebert S, Ullemar V, Verduci E, Vonk JM, Xu CJ, Yang IV, Zhang H, Zhang W, Karmaus W, Dabelea D, Muhlhausler BS, Breton CV, Lahti J, Almqvist C, Jarvelin MR, Koletzko B, Vrijheid M, Sorensen TIA, Huang RC, Arshad SH, Nystad W, Melen E, Koppelman GH, London SJ, Holland N, Bustamante M, Murphy SK, Hivert MF, Baccarelli A, Relton CL, Snieder H, Jaddoe VWV, Felix JF
Genome Med. 2020 Nov 25;12(1):105. doi: 10.1186/s13073-020-00810-w. Epub 2020 Nov 25.
PMID: 33239103

Altered immune phenotype and DNA methylation in panic disorder.
Petersen CL, Chen JQ, Salas LA, Christensen BC
Clin Epigenetics. 2020 Nov 18;12(1):177. doi: 10.1186/s13148-020-00972-9. Epub 2020 Nov 18.
PMID: 33208194

Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis.
Yeung EH, Guan W, Zeng X, Salas LA, Mumford SL, de Prado Bert P, van Meel ER, Malmberg A, Sunyer J, Duijts L, Felix JF, Czamara D, Hamalainen E, Binder EB, Raikkonen K, Lahti J, London SJ, Silver RM, Schisterman EF
Clin Epigenetics. 2020 Apr 30;12(1):60. doi: 10.1186/s13148-020-00852-2. Epub 2020 Apr 30.
PMID: 32354366

Enrichment of CpG island shore region hypermethylation in epigenetic breast field cancerization.
Muse ME, Titus AJ, Salas LA, Wilkins OM, Mullen C, Gregory KJ, Schneider SS, Crisi GM, Jawale RM, Otis CN, Christensen BC, Arcaro KF
Epigenetics. 2020 Oct;15(10):1093-1106. doi: 10.1080/15592294.2020.1747748. Epub 2020 Apr 7.
PMID: 32255732

MethylNet: an automated and modular deep learning approach for DNA methylation analysis.
Levy JJ, Titus AJ, Petersen CL, Chen Y, Salas LA, Christensen BC
BMC Bioinformatics. 2020 Mar 17;21(1):108. doi: 10.1186/s12859-020-3443-8. Epub 2020 Mar 17.
PMID: 32183722

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.
Merid SK, Novoloaca A, Sharp GC, Kupers LK, Kho AT, Roy R, Gao L, Annesi-Maesano I, Jain P, Plusquin M, Kogevinas M, Allard C, Vehmeijer FO, Kazmi N, Salas LA, Rezwan FI, Zhang H, Sebert S, Czamara D, Rifas-Shiman SL, Melton PE, Lawlor DA, Pershagen G, Breton CV, Huen K, Baiz N, Gagliardi L, Nawrot TS, Corpeleijn E, Perron P, Duijts L, Nohr EA, Bustamante M, Ewart SL, Karmaus W, Zhao S, Page CM, Herceg Z, Jarvelin MR, Lahti J, Baccarelli AA, Anderson D, Kachroo P, Relton CL, Bergstrom A, Eskenazi B, Soomro MH, Vineis P, Snieder H, Bouchard L, Jaddoe VW, Sorensen TIA, Vrijheid M, Arshad SH, Holloway JW, Haberg SE, Magnus P, Dwyer T, Binder EB, DeMeo DL, Vonk JM, Newnham J, Tantisira KG, Kull I, Wiemels JL, Heude B, Sunyer J, Nystad W, Munthe-Kaas MC, Raikkonen K, Oken E, Huang RC, Weiss ST, Anto JM, Bousquet J, Kumar A, Soderhall C, Almqvist C, Cardenas A, Gruzieva O, Xu CJ, Reese SE, Kere J, Brodin P, Solomon O, Wielscher M, Holland N, Ghantous A, Hivert MF, Felix JF, Koppelman GH, London SJ, Melen E
Genome Med. 2020 Mar 2;12(1):25. doi: 10.1186/s13073-020-0716-9. Epub 2020 Mar 2.
PMID: 32114984

Prediagnostic breast milk DNA methylation alterations in women who develop breast cancer.
Salas LA, Lundgren SN, Browne EP, Punska EC, Anderton DL, Karagas MR, Arcaro KF, Christensen BC
Hum Mol Genet. 2020 Mar 13;29(4):662-673. doi: 10.1093/hmg/ddz301.
PMID: 31943067

Newborn and childhood differential DNA methylation and liver fat in school-age children.
Geurtsen ML, Jaddoe VWV, Salas LA, Santos S, Felix JF
Clin Epigenetics. 2019 Dec 31;12(1):3. doi: 10.1186/s13148-019-0799-6. Epub 2019 Dec 31.
PMID: 31892367

PathFlowAI: A High-Throughput Workflow for Preprocessing, Deep Learning and Interpretation in Digital Pathology.
Levy JJ, Salas LA, Christensen BC, Sriharan A, Vaickus LJ
Pac Symp Biocomput. 2020;25:403-414.
PMID: 31797614

Maternal Gestational Diabetes Mellitus and Newborn DNA Methylation: Findings From the Pregnancy and Childhood Epigenetics Consortium.
Howe CG, Cox B, Fore R, Jungius J, Kvist T, Lent S, Miles HE, Salas LA, Rifas-Shiman S, Starling AP, Yousefi P, Ladd-Acosta C, Baccarelli A, Binder EB, Chatzi VL, Czamara D, Dabelea D, DeMeo DL, Ghantous A, Herceg Z, Kajantie E, Lahti JMT, Lawlor DA, Litonjua A, Nawrot TS, Nohr EA, Oken E, Pizzi C, Plusquin M, Raikkonen K, Relton CL, Sharp GC, Sorensen TIA, Sunyer J, Vrijheid M, Zhang W, Hivert MF, Breton CV
Diabetes Care. 2020 Jan;43(1):98-105. doi: 10.2337/dc19-0524. Epub 2019 Oct 10.
PMID: 31601636

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