Lucas A Salas, MD, MPH, PhD
Title(s)
Assistant Professor of Epidemiology
Additional Titles/Positions/Affiliations
Investigator Cancer Population Sciences Research Program, Dartmouth Hitchcock- Norris Cotton Cancer Center
Department(s)
Epidemiology
Education
Universitat Pompeu Fabra, PhD 2015
Universitat Pompeu Fabra, MPH 2011
Universidad de Antioquia, Epidemiology 2007
Universidad Nacional de Colombia, MD 2001
Programs
Quantitative Biomedical Sciences
Other
NIH Biosketch
Salas_L_BIO_2020-09-21.pdf
Websites
https:
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Contact Information
Email: Lucas.A.Salas@Dartmouth.edu
Professional Interests
The broad goal of Dr. Salas research is to investigate how cell heterogeneity impacts human health and disease, with an emphasis on how genetic, environmental, and lifestyle factors model the human epigenome and therefore the cell plasticity. Dr. Salas’ laboratory studies how some key epigenetic mechanisms (DNA methylation, DNA hydroxymethylation, and miRNA alterations) affect gene expression and cancer outcomes, including how the immune cells are altered in this disease. Other research interests include biomarker development, chronic inflammation, and human disease, and how exposures during fetal life alter newborn and childhood outcomes.
Grant Information
W81XWH-20-1-0778, Congressionally Directed Medical Research Programs/Department of Defense
Salas Diaz, Lucas A (PI) 09/01/20-08/31/24
Epigenetic modifications of cytosines in clear cell kidney carcinogenesis and survival
P20 GM104416-09/8299, National Institute of General Medical Sciences
Salas Diaz, Lucas A (PI) 10/01/20-01/01/23
A single-cell approach to disentangle tumor microenvironments in short and long survivors to clear cell renal carcinoma
Courses Taught
QBS.132
CANB.103
MDED.118
QBS.271
PEMM.212
Mentoring Information
Current trainees:
Ze Zhang, QBS
Steven Pike, IND
Prasoona Karra, Ph.D. (postdoctoral fellow)
Chinaza Nnam, MCB (rotation student)
Extensive epigenomic dysregulation is a hallmark of homologous recombination deficiency in triple-negative breast cancer. Insights to aging prediction with AI based epigenetic clocks. Methylation cytometric pretreatment blood immune profiles with tumor mutation burden as prognostic indicators for survival outcomes in head and neck cancer patients on anti-PD-1 therapy. Glioma immune microenvironment composition calculator (GIMiCC): a method of estimating the proportions of eighteen cell types from DNA methylation microarray data. An initial game-theoretic assessment of enhanced tissue preparation and imaging protocols for improved deep learning inference of spatial transcriptomics from tissue morphology. An assessment of compositional methods for the analysis of DNA methylation-based deconvolution estimates. Recalibrate concepts of epigenetic aging clocks in human health. Immunomethylomic profiles of long-term head and neck squamous cell carcinoma survivors on immune checkpoint inhibitors. Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms. Associations in cell type-specific hydroxymethylation and transcriptional alterations of pediatric central nervous system tumors. |
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