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Lucas A Salas, MD, MPH, PhD

Title(s):
Assistant Professor of Epidemiology

Additional Titles/Positions/Affiliations:
Investigator Cancer Population Sciences Research Program, Dartmouth Hitchcock- Norris Cotton Cancer Center

Department(s):
Epidemiology

Education:
Universitat Pompeu Fabra, PhD 2015
Universitat Pompeu Fabra, MPH 2011
Universidad de Antioquia, Epidemiology 2007
Universidad Nacional de Colombia, MD 2001

Programs:
Quantitative Biomedical Sciences

NIH Biosketch:
Salas_L_BIO_2020-09-21.pdf

Websites:
https://orcid.org/0000-0002-2279-4097
https://scholar.google.com/citations?user=FsRf5lQAAAAJ&hl=en
https://publons.com/researcher/1222796/lucas-a-salas/
https://bioconductor.org/packages/release/data/experiment/html/FlowSorted.Blood.EPIC.html
https://bioconductor.org/packages/release/data/experiment/html/FlowSorted.CordBloodCombined.450k.html

Contact Information:


Professional Interests:

The broad goal of Dr. Salas research is to investigate how cell heterogeneity impacts human health and disease, with an emphasis on how genetic, environmental, and lifestyle factors model the human epigenome and therefore the cell plasticity. Dr. Salas’ laboratory studies how some key epigenetic mechanisms (DNA methylation, DNA hydroxymethylation, and miRNA alterations) affect gene expression and cancer outcomes, including how the immune cells are altered in this disease. Other research interests include biomarker development, chronic inflammation, and human disease, and how exposures during fetal life alter newborn and childhood outcomes.

Grant Information:

W81XWH-20-1-0778, Congressionally Directed Medical Research Programs/Department of Defense
Salas Diaz, Lucas A (PI) 09/01/20-08/31/24
Epigenetic modifications of cytosines in clear cell kidney carcinogenesis and survival
P20 GM104416-09/8299, National Institute of General Medical Sciences
Salas Diaz, Lucas A (PI) 10/01/20-01/01/23
A single-cell approach to disentangle tumor microenvironments in short and long survivors to clear cell renal carcinoma

Courses Taught:

PEMM.103
MDED.118
QBS.271

Mentoring Information:

Current trainees:
Ze Zhang, QBS
Steven Pike, IND
Jennifer Chen (Biology '23)
Michael Mariani, Ph.D. (postdoctoral fellow)


Selected Publications:

 

Interactions of Age and Blood Immune Factors and Non-Invasive Prediction of Glioma Survival.
Molinaro AM, Wiencke JK, Warrier G, Koestler DC, Chunduru P, Lee JY, Hansen HM, Lee S, Anguiano J, Rice T, Bracci PM, McCoy L, Salas LA, Christensen BC, Wrensch M, Kelsey KT, Taylor JW, Clarke JL
J Natl Cancer Inst. 2021 Oct 1; pii: djab195. doi: 10.1093/jnci/djab195. Epub 2021 Oct 1.
PMID: 34597382

DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker.
Azizgolshani N, Petersen CL, Chen Y, Levy JJ, Salas LA, Perreard L, Nguyen LN, Christensen BC
Clin Epigenetics. 2021 Sep 19;13(1):176. doi: 10.1186/s13148-021-01156-9. Epub 2021 Sep 19.
PMID: 34538273

MethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Networks, Inspired by Capsule Networks.
Levy JJ, Chen Y, Azizgolshani N, Petersen CL, Titus AJ, Moen EL, Vaickus LJ, Salas LA, Christensen BC
NPJ Syst Biol Appl. 2021 Aug 20;7(1):33. doi: 10.1038/s41540-021-00193-7. Epub 2021 Aug 20.
PMID: 34417465

Identification of a foetal epigenetic compartment in adult human kidney.
Wiencke JK, Zhang Z, Koestler DC, Salas LA, Molinaro AM, Christensen BC, Kelsey KT
Epigenetics. 2021 Mar 30;:1-21. doi: 10.1080/15592294.2021.1900027. Epub 2021 Mar 30.
PMID: 33783321

A transdisciplinary approach to understand the epigenetic basis of race/ethnicity health disparities.
Salas LA, Peres LC, Thayer ZM, Smith RW, Guo Y, Chung W, Si J, Liang L
Epigenomics. 2021 Mar 10; doi: 10.2217/epi-2020-0080. Epub 2021 Mar 10.
PMID: 33719520

DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies.
Vehmeijer FOL, Kupers LK, Sharp GC, Salas LA, Lent S, Jima DD, Tindula G, Reese S, Qi C, Gruzieva O, Page C, Rezwan FI, Melton PE, Nohr E, Escaramis G, Rzehak P, Heiskala A, Gong T, Tuominen ST, Gao L, Ross JP, Starling AP, Holloway JW, Yousefi P, Aasvang GM, Beilin LJ, Bergstrom A, Binder E, Chatzi L, Corpeleijn E, Czamara D, Eskenazi B, Ewart S, Ferre N, Grote V, Gruszfeld D, Haberg SE, Hoyo C, Huen K, Karlsson R, Kull I, Langhendries JP, Lepeule J, Magnus MC, Maguire RL, Molloy PL, Monnereau C, Mori TA, Oken E, Raikkonen K, Rifas-Shiman S, Ruiz-Arenas C, Sebert S, Ullemar V, Verduci E, Vonk JM, Xu CJ, Yang IV, Zhang H, Zhang W, Karmaus W, Dabelea D, Muhlhausler BS, Breton CV, Lahti J, Almqvist C, Jarvelin MR, Koletzko B, Vrijheid M, Sorensen TIA, Huang RC, Arshad SH, Nystad W, Melen E, Koppelman GH, London SJ, Holland N, Bustamante M, Murphy SK, Hivert MF, Baccarelli A, Relton CL, Snieder H, Jaddoe VWV, Felix JF
Genome Med. 2020 Nov 25;12(1):105. doi: 10.1186/s13073-020-00810-w. Epub 2020 Nov 25.
PMID: 33239103

Altered immune phenotype and DNA methylation in panic disorder.
Petersen CL, Chen JQ, Salas LA, Christensen BC
Clin Epigenetics. 2020 Nov 18;12(1):177. doi: 10.1186/s13148-020-00972-9. Epub 2020 Nov 18.
PMID: 33208194

Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis.
Yeung EH, Guan W, Zeng X, Salas LA, Mumford SL, de Prado Bert P, van Meel ER, Malmberg A, Sunyer J, Duijts L, Felix JF, Czamara D, Hamalainen E, Binder EB, Raikkonen K, Lahti J, London SJ, Silver RM, Schisterman EF
Clin Epigenetics. 2020 Apr 30;12(1):60. doi: 10.1186/s13148-020-00852-2. Epub 2020 Apr 30.
PMID: 32354366

Enrichment of CpG island shore region hypermethylation in epigenetic breast field cancerization.
Muse ME, Titus AJ, Salas LA, Wilkins OM, Mullen C, Gregory KJ, Schneider SS, Crisi GM, Jawale RM, Otis CN, Christensen BC, Arcaro KF
Epigenetics. 2020 Oct;15(10):1093-1106. doi: 10.1080/15592294.2020.1747748. Epub 2020 Apr 7.
PMID: 32255732

MethylNet: an automated and modular deep learning approach for DNA methylation analysis.
Levy JJ, Titus AJ, Petersen CL, Chen Y, Salas LA, Christensen BC
BMC Bioinformatics. 2020 Mar 17;21(1):108. doi: 10.1186/s12859-020-3443-8. Epub 2020 Mar 17.
PMID: 32183722

View more publications on PubMed