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Lucas A Salas, MD, MPH, PhD

Assistant Professor of Epidemiology

Additional Titles/Positions/Affiliations
Investigator Cancer Population Sciences Research Program, Dartmouth Hitchcock- Norris Cotton Cancer Center


Universitat Pompeu Fabra, PhD 2015
Universitat Pompeu Fabra, MPH 2011
Universidad de Antioquia, Epidemiology 2007
Universidad Nacional de Colombia, MD 2001

Quantitative Biomedical Sciences

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Contact Information

Professional Interests

The broad goal of Dr. Salas research is to investigate how cell heterogeneity impacts human health and disease, with an emphasis on how genetic, environmental, and lifestyle factors model the human epigenome and therefore the cell plasticity. Dr. Salas’ laboratory studies how some key epigenetic mechanisms (DNA methylation, DNA hydroxymethylation, and miRNA alterations) affect gene expression and cancer outcomes, including how the immune cells are altered in this disease. Other research interests include biomarker development, chronic inflammation, and human disease, and how exposures during fetal life alter newborn and childhood outcomes.

Grant Information

W81XWH-20-1-0778, Congressionally Directed Medical Research Programs/Department of Defense
Salas Diaz, Lucas A (PI) 09/01/20-08/31/24
Epigenetic modifications of cytosines in clear cell kidney carcinogenesis and survival
P20 GM104416-09/8299, National Institute of General Medical Sciences
Salas Diaz, Lucas A (PI) 10/01/20-01/01/23
A single-cell approach to disentangle tumor microenvironments in short and long survivors to clear cell renal carcinoma

Courses Taught


Mentoring Information

Current trainees:
Ze Zhang, QBS
Steven Pike, IND
Prasoona Karra, Ph.D. (postdoctoral fellow)
Chinaza Nnam, MCB (rotation student)

Selected Publications


Enrichment of a neutrophil-like monocyte transcriptional state in glioblastoma myeloid suppressor cells.
Wiencke JK, Nissen E, Koestler DC, Tamaki SJ, Tamaki CM, Hansen HM, Warrier G, Hadad S, McCoy L, Rice T, Clarke J, Taylor JW, Salas LA, Christensen BC, Kelsey KT, Butler R, Molinaro AM
Res Sq. 2023 Dec 28; pii: rs.3.rs-3793353. doi: 10.21203/rs.3.rs-3793353/v1. Epub 2023 Dec 28.
PMID: 38234734

Matched analysis of detailed peripheral blood and tumor immune microenvironment profiles in bladder cancer.
Chen JQ, Salas LA, Wiencke JK, Koestler DC, Molinaro AM, Andrew AS, Seigne JD, Karagas MR, Kelsey KT, Christensen BC
Epigenomics. 2024 Jan;16(1):41-56. doi: 10.2217/epi-2023-0358. Epub 2024 Jan 15.
PMID: 38221889

Immunological shifts during early-stage Parkinson's disease identified with DNA methylation data on longitudinally collected blood samples.
Pike SC, Havrda M, Gilli F, Zhang Z, Salas LA
NPJ Parkinsons Dis. 2024 Jan 11;10(1):21. doi: 10.1038/s41531-023-00626-6. Epub 2024 Jan 11.
PMID: 38212355

Tumor microenvironment deconvolution identifies cell-type-independent aberrant DNA methylation and gene expression in prostate cancer.
Reynolds SR, Zhang Z, Salas LA, Christensen BC
Clin Epigenetics. 2024 Jan 3;16(1):5. doi: 10.1186/s13148-023-01609-3. Epub 2024 Jan 3.
PMID: 38173042

Potential to Enhance Large Scale Molecular Assessments of Skin Photoaging through Virtual Inference of Spatial Transcriptomics from Routine Staining.
Srinivasan G, Davis MJ, LeBoeuf MR, Fatemi M, Azher ZL, Lu Y, Diallo AB, Saldias Montivero MK, Kolling FW, Perrard L, Salas LA, Christensen BC, Palys TJ, Karagas MR, Palisoul SM, Tsongalis GJ, Vaickus LJ, Preum SM, Levy JJ
Pac Symp Biocomput. 2024;29:477-491.
PMID: 38160301

Spatial Omics Driven Crossmodal Pretraining Applied to Graph-based Deep Learning for Cancer Pathology Analysis.
Azher ZL, Fatemi M, Lu Y, Srinivasan G, Diallo AB, Christensen BC, Salas LA, Kolling FW, Perreard L, Palisoul SM, Vaickus LJ, Levy JJ
Pac Symp Biocomput. 2024;29:464-476.
PMID: 38160300

Deciphering the role of immune cell composition in epigenetic age acceleration: Insights from cell-type deconvolution applied to human blood epigenetic clocks.
Zhang Z, Reynolds SR, Stolrow HG, Chen JQ, Christensen BC, Salas LA
Aging Cell. 2024 Mar;23(3):e14071. doi: 10.1111/acel.14071. Epub 2023 Dec 25.
PMID: 38146185

Detailed immune profiling in pediatric Crohn's disease using methylation cytometry.
Reynolds SR, Salas LA, Chen JQ, Christensen BC
Epigenetics. 2024 Dec;19(1):2289786. doi: 10.1080/15592294.2023.2289786. Epub 2023 Dec 13.
PMID: 38090774

Molecular subtypes of high-grade serous ovarian cancer across racial groups and gene expression platforms.
Davidson NR, Barnard ME, Hippen AA, Campbell A, Johnson CE, Way GP, Dalley BK, Berchuck A, Salas LA, Peres LC, Marks JR, Schildkraut JM, Greene CS, Doherty JA
bioRxiv. 2023 Dec 2; pii: 2023.11.01.565179. doi: 10.1101/2023.11.01.565179. Epub 2023 Dec 2.
PMID: 37961178

The Overlooked Role of Specimen Preparation in Bolstering Deep Learning-Enhanced Spatial Transcriptomics Workflows.
Fatemi MY, Lu Y, Diallo AB, Srinivasan G, Azher ZL, Christensen BC, Salas LA, Tsongalis GJ, Palisoul SM, Perreard L, Kolling FW, Vaickus LJ, Levy JJ
medRxiv. 2023 Oct 9; pii: 2023.10.09.23296700. doi: 10.1101/2023.10.09.23296700. Epub 2023 Oct 9.
PMID: 37873287

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