Lucas A Salas, MD, MPH, PhD
Title(s)
Assistant Professor of Epidemiology
Additional Titles/Positions/Affiliations
Investigator Cancer Population Sciences Research Program, Dartmouth Hitchcock- Norris Cotton Cancer Center
Department(s)
Epidemiology
Education
Universitat Pompeu Fabra, PhD 2015
Universitat Pompeu Fabra, MPH 2011
Universidad de Antioquia, Epidemiology 2007
Universidad Nacional de Colombia, MD 2001
Programs
Quantitative Biomedical Sciences
Other
NIH Biosketch
Salas_L_BIO_2020-09-21.pdf
Websites
https:
https:
https:
https:
https:
https:
Contact Information
Email: Lucas.A.Salas@Dartmouth.edu
Professional Interests
The broad goal of Dr. Salas research is to investigate how cell heterogeneity impacts human health and disease, with an emphasis on how genetic, environmental, and lifestyle factors model the human epigenome and therefore the cell plasticity. Dr. Salas’ laboratory studies how some key epigenetic mechanisms (DNA methylation, DNA hydroxymethylation, and miRNA alterations) affect gene expression and cancer outcomes, including how the immune cells are altered in this disease. Other research interests include biomarker development, chronic inflammation, and human disease, and how exposures during fetal life alter newborn and childhood outcomes.
Grant Information
W81XWH-20-1-0778, Congressionally Directed Medical Research Programs/Department of Defense
Salas Diaz, Lucas A (PI) 09/01/20-08/31/24
Epigenetic modifications of cytosines in clear cell kidney carcinogenesis and survival
P20 GM104416-09/8299, National Institute of General Medical Sciences
Salas Diaz, Lucas A (PI) 10/01/20-01/01/23
A single-cell approach to disentangle tumor microenvironments in short and long survivors to clear cell renal carcinoma
Courses Taught
QBS.132
CANB.103
MDED.118
QBS.271
PEMM.212
Mentoring Information
Current trainees:
Ze Zhang, QBS
Steven Pike, IND
Prasoona Karra, Ph.D. (postdoctoral fellow)
David Vargas-Estrella (Neurosciences '23)
Selected Publications |
|
HiTIMED: hierarchical tumor immune microenvironment epigenetic deconvolution for accurate cell type resolution in the tumor microenvironment using tumor-type-specific DNA methylation data. Evaluation of cross-platform compatibility of a DNA methylation-based glucocorticoid response biomarker. DNA methylation as a pharmacodynamic marker of glucocorticoid response and glioma survival. MethylMasteR: A Comparison and Customization of Methylation-Based Copy Number Variation Calling Software in Cancers Harboring Large Scale Chromosomal Deletions. A Novel Framework for the Identification of Reference DNA Methylation Libraries for Reference-Based Deconvolution of Cellular Mixtures. Phase I Study of High-Dose L-methylfolate in Combination with Temozolomide and Bevacizumab in Recurrent IDH wild-type High-Grade Glioma. A core of differentially methylated CpG loci in gMDSCs isolated from neonatal and adult sources. Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling. Immune profiles and DNA methylation alterations related with non-muscle-invasive bladder cancer outcomes. Navigating the hydroxymethylome: experimental biases and quality control tools for the tandem bisulfite and oxidative bisulfite Illumina microarrays. |
|