Lucas A Salas, MD, MPH, PhD
Title(s):
Assistant Professor of Epidemiology
Additional Titles/Positions/Affiliations:
Investigator Cancer Population Sciences Research Program, Dartmouth Hitchcock- Norris Cotton Cancer Center
Department(s):
Epidemiology
Education:
Universitat Pompeu Fabra, PhD 2015
Universitat Pompeu Fabra, MPH 2011
Universidad de Antioquia, Epidemiology 2007
Universidad Nacional de Colombia, MD 2001
Programs:
Quantitative Biomedical Sciences
NIH Biosketch:
Salas_L_BIO_2020-09-21.pdf
Websites:
https:
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Contact Information:
Email: Lucas.A.Salas@Dartmouth.edu
Professional Interests:
The broad goal of Dr. Salas research is to investigate how cell heterogeneity impacts human health and disease, with an emphasis on how genetic, environmental, and lifestyle factors model the human epigenome and therefore the cell plasticity. Dr. Salas’ laboratory studies how some key epigenetic mechanisms (DNA methylation, DNA hydroxymethylation, and miRNA alterations) affect gene expression and cancer outcomes, including how the immune cells are altered in this disease. Other research interests include biomarker development, chronic inflammation, and human disease, and how exposures during fetal life alter newborn and childhood outcomes.
Grant Information:
W81XWH-20-1-0778, Congressionally Directed Medical Research Programs/Department of Defense
Salas Diaz, Lucas A (PI) 09/01/20-08/31/24
Epigenetic modifications of cytosines in clear cell kidney carcinogenesis and survival
P20 GM104416-09/8299, National Institute of General Medical Sciences
Salas Diaz, Lucas A (PI) 10/01/20-01/01/23
A single-cell approach to disentangle tumor microenvironments in short and long survivors to clear cell renal carcinoma
Courses Taught:
PEMM.103
MDED.118
QBS.271
Mentoring Information:
Current trainees:
Ze Zhang, QBS
Steven Pike, IND
Jennifer Chen (Biology '23)
Michael Mariani, Ph.D. (postdoctoral fellow)
Selected Publications: |
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Interactions of Age and Blood Immune Factors and Non-Invasive Prediction of Glioma Survival. DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker. MethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Networks, Inspired by Capsule Networks. Identification of a foetal epigenetic compartment in adult human kidney. A transdisciplinary approach to understand the epigenetic basis of race/ethnicity health disparities. DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies. Altered immune phenotype and DNA methylation in panic disorder. Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis. Enrichment of CpG island shore region hypermethylation in epigenetic breast field cancerization. MethylNet: an automated and modular deep learning approach for DNA methylation analysis. |
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