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Samuel A. Lee, MD, PhD

Professor of Medicine

Additional Titles/Positions/Affiliations
Vice Chair for VA Affairs, Department of Medicine
Chief, Medicine Service, White River Junction VAMC


BA/MD Boston University, 1993
Internship and residency, Internal Medicine, Hospital of the University of Pennsylvania, 1996
Fellowship, Infectious Diseases, Yale New Haven Hospital, 2000
Ph.D Yale Graduate School, 2005

Contact Information

Office: 802-295-9363 x5484

Assistant: Tammy Willens

Professional Interests

Fungal pathogenesis, secretion, virulence, biofilm formation, antifungal drug discovery.

Our laboratory studies the molecular pathogenesis of invasive candidiasis and also investigates translational aspects of Candida infection, including mechanisms of biofilm formation, drug repurposing, and antifungal drug discovery. A major objective of our laboratory is to define the secretory pathways of secreted virulence proteins and determine if mutations in these pathways have an effect on biofilm formation and virulence in vivo. Our laboratory is currently studying the role of endocytosis in aspartyl protease secretion, filamentation, biofilm formation, and in vivo virulence. This work is supported by a Department of Veterans Affairs Merit award. Our lab is also involved in translational research on novel antifungal therapies and treatment approaches against biofilm formation in Candida species, including drug repurposing, high-throughput screening of small molecule compound libraries, and studies of antifungal lock therapies for prevention of catheter-associated infections. Our high-throughput screening work is supported by NIH NIAID.

Grant Information

Department of Veterans Affairs Merit Award


Dr. Lee is a graduate of the Seven-Year Combined BA/MD Program at Boston University. He completed his internship and residency at the Hospital of the University of Pennsylvania. He then trained in a 3-year research track fellowship in Infectious Diseases at Yale University School of Medicine, and continued at Yale as a Staff Physician at VA Connecticut Healthcare System. He also obtained his Ph.D in Investigative Medicine in the Yale Graduate School. Dr. Lee then became an Assistant Professor of Medicine in the Division of Infectious Diseases, at the University of Texas Health Science Center at San Antonio, and a member of the San Antonio Center for Medical Mycology. He joined the faculty at University of New Mexico in September of 2007, as Section Chief, Infectious Diseases at VA Albuquerque Medical Center, and Medical Director of the HIV clinic at VA Albuquerque. Dr. Lee was promoted to Associate Professor with tenure, then Professor and Regents' Lecturer. Dr. Lee joined the faculty at Geisel School of Medicine at Dartmouth in August 2018, as Professor of Medicine and Chief, Medicine Service at the White River Junction VA Medical Center.