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Daniel Schultz, PhD

Title(s):
Assistant Professor of Microbiology and Immunology

Additional Titles/Positions/Affiliations:
Neukom Cluster of Computational Science

Department(s):
Microbiology and Immunology

Education:
Postdoc - Systems Biology, Harvard Medical School
Ph.D. - Theoretical Biological Physics, UC San Diego
Eng. - Electronics Engineering, ITA (Brazil)

Programs:
Molecular and Cellular Biology Graduate Programs
Molecular Pathogenesis Program
Quantitative Biomedical Sciences

Websites:
https://geiselmed.dartmouth.edu/schultz/

Contact Information:

74 College street
206 Vail Building
Hanover NH 03755

Office: 206 Vail Bldg.
Phone: 603-650-1644
Email: Daniel.Schultz@Dartmouth.edu


Professional Interests:

Dr. Schultz combines theoretical and experimental approaches to study the emergence, operation and optimization of gene networks, with a focus in antibiotic responses in bacteria. He uses basic evolution experiments, bioinformatics and mathematical models to investigate the evolution of gene regulation in the context of dynamical responses. He intends to guide innovation in clinical therapies by uncovering the selective pressures that shape the evolution of antibiotic resistance.

Biography:

Dr. Schultz has a background in electrical engineering from the Technological Institute of Aeronautics, in his native Brazil. He started his academic career investigating the stability of small carbon nanoparticles. He moved to the US for a Ph.D. in Chemistry and Biochemistry at UC San Diego, working at the Center for Theoretical Biological Physics with Dr. Peter Wolynes, where he used stochastic models of gene regulation to study the role of noise in bacterial networks performing cell decisions. For his postdoctoral work Dr. Schultz moved to Dr. Roy Kishony’s lab, at the Department of Systems Biology at Harvard Medical School, where he developed both theoretical and experimental approaches to uncover the design principles that shape the evolution of antibiotic resistance mechanisms in bacteria.


Selected Publications:

 

  • D Schultz, AC Palmer, R Kishony. Regulatory dynamics determine cell fate following abrupt antibiotic exposure. Cell Systems (2017) (view details on MedLine)

  • D Schultz, PG Wolynes, EB Jacob, JN Onuchic. Deciding fate in adverse times: sporulation and competence in Bacillus subtilis. PNAS (2009) (view details on MedLine)

  • D Schultz, EB Jacob, JN Onuchic, PG Wolynes. Molecular level stochastic model for competence cycles in Bacillus subtilis. PNAS (2007) (view details on MedLine)

  • D Schultz, AM Walczak, JN Onuchic, PG Wolynes. Extinction and resurrection in gene networks. PNAS (2008) (view details on MedLine)

  • JEM Hornos, D Schultz, GCP Innocentini, J Wang, AM Walczak, JN Onuchic, PG Wolynes. Self-regulating gene: an exact solution. Physical Review E (2005)

  • D Schultz, JN Onuchic, PG Wolynes. Understanding stochastic simulations of the smallest genetic networks. Journal of Chemical Physics (2007)

  • D Schultz, R Droppa Jr, F Alvarez, MC Dos Santos. Stability of small carbon-nitride heterofullerenes. Physical Review Letters (2003)