Matthew S Hayden, MD, PhD
Assistant Professor of Surgery
M.D., Yale School of Medicine
Ph.D., Yale School of Medicine
M.Phil., Yale School of Medicine
M.S., Yale School of Medicine
B.A., Oberlin College
Program in Experimental and Molecular Medicine
1 Medical Center Drive
Lab: Borwell 550E
Lebanon NH 03756
Office: Borwell 554E
Immune Signaling in Inflammation, Autoimmunity, and Cancer
Dysregulation of the immune response is a hallmark of disease. Unchecked innate and adaptive immunity can lead to chronic inflammation or autoimmunity, while compromised immune responses facilitate infection and tumorigenesis. The NF-kappaB signaling pathway is an essential mediator of communication amongst cells of the immune system and between the immune system and non-immune host cells. Dysregulation of NF-kappaB in autoimmunity and cancer is well described, yet effective clinical targeting of the pathway has not been achieved. In the Hayden lab, we are interested in elucidating the mechanisms leading to NF-kappaB dysregulation and are working to identify more selective approaches to manipulating NF-kappaB signaling in order to develop novel immunomodulatory therapies.
Rotations and Thesis Projects:
Specificity in the NF-kappaB Pathway – Using a combination of genome engineering, next generation sequencing, and bioinformatics to delineate the function of specific NF-kappaB transcription factors and identify novel, selective inhibitors of the NF-kappaB pathway.
Enhanced Tumor Targeting - Develop a novel, combination therapeutic to enhance the delivery of drugs and other cargoes to tumor cells.
Chronic Inflammatory Responses In Psoriasis. Using novel next generation sequencing approaches to investigate the mechanisms by which cytokine signaling results in sustain inflammatory transcriptional responses in keratinocytes.
Characterization of a Tumor Suppressor. Use genome engineering and targeted resequencing to characterize the function of a novel tumor suppressor in non-melanoma skin cancer.
Detection and Targeting of Oncoviruses. We are using CRISPR and NGS to target, detect, and understand viruses that cause human cancers.
Work in the Hayden lab is currently has funding from the Section of Dermatology, Department of Surgery; BioMT Pilot Project - NIH/NIGMS P20GM113132; NIH/NIGMS SBIR R43GM133289.
Dr. Hayden received his B.A. in 1994 in biology from Oberlin College, Oberlin OH. In 1998 he joined the Gladstone Institute of Virology and Immunology as a research assistant, where he worked on HIV drug resistance and viral fitness. In 2000 he entered the MSTP at Yale Medical School, performing doctoral research in the department of Immunobiology. From 2010-2011 Dr. Hayden did post-doctoral research at Columbia University, before becoming an Assistant Professor in the Departments of Dermatology and Microbiology & Immunology at Columbia University Medical Center, where, in 2013 he was named the George Henry Fox Assistant Professor of Dermatology and Columbia University Medical Center. Dr. Hayden joined the Section of Dermatology, Department of Surgery at Dartmouth-Hitchcock Medical Center and Geisel School of Medicine in 2017.
Carneiro FRG, Lepelley A, Seeley JJ, Hayden MS, Ghosh S An Essential Role for ECSIT in Mitochondrial Complex I Assembly and Mitophagy in Macrophages. Cell Rep. 2018 Mar 6;22(10):2654-2666 (view details on MedLine)
Grinberg-Bleyer Y, Caron R, Seeley JJ, De Silva NS, Schindler CW, Hayden MS, Klein U, Ghosh S The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function. J Immunol. 2018 Apr 1;200(7):2362-2371. (view details on MedLine)
Oh H, Grinberg-Bleyer Y, Liao W, Maloney D, Wang P, Wu Z, Wang J, Bhatt DM, Heise N, Schmid RM, Hayden MS, Klein U, Rabadan R, Ghosh S An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function. Immunity. 2017 Sep 19;47(3):450-465.e5. (view details on MedLine)
Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS, Ghosh S. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. 2017 Sep 7;170(6):1096-1108.e13 (view details on MedLine)
Dainichi T, Hayden MS, Park SG, Oh H, Seeley JJ, Grinberg-Bleyer Y, Beck KM, Miyachi Y, Kabashima K, Hashimoto T, Ghosh S PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division. Cell Rep. 2016 May 24;15(8):1615-23. (view details on MedLine)
Grinberg-Bleyer Y, Dainichi T, Oh H, Heise N, Klein U, Schmid RM, Hayden MS, Ghosh S Cutting edge: NF-κB p65 and c-Rel control epidermal development and immune homeostasis in the skin. J Immunol. 2015 Mar 15;194(6):2472-6. (view details on MedLine)
Gurunathan S, Winkles JA, Ghosh S, Hayden MS. Regulation of fibroblast growth factor-inducible 14 (Fn14) expression levels via ligand-independent lysosomal degradation. J Biol Chem. 2014 May 9;289(19):12976-88. (view details on MedLine)
Seeley JJ, Baker RG, Mohamed G, Bruns T, Hayden MS, Deshmukh SD, Freedberg DE, Ghosh S. Induction of innate immune memory via microRNA targeting of chromatin remodelling factors. Nature. 2018 Jul;559(7712):114-119. (view details on MedLine)
Rao P, Hayden MS, Long M, Scott ML, West AP, Zhang D, Oeckinghaus A, Lynch C, Hoffmann A, Baltimore D, Ghosh S. IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response. Nature. 2010 Aug 26;466(7310):1115-9. (view details on MedLine)
Park SG, Mathur R, Long M, Hosh N, Hao L, Hayden MS, Ghosh S. T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells. Immunity. 2010 Nov 24;33(5):791-803 (view details on MedLine)