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Jibran Y Khokhar, PhD

Title(s):
Adjunct Assistant Professor of Psychiatry

Additional Titles/Positions/Affiliations:
Lecturer in Psychological and Brain Sciences

Department(s):
Psychiatry

Education:
Ph.D. – University of Toronto, Toronto, Ontario
Department of Pharmacology and Toxicology
Trainee at Centre for Addiction and Mental Health

B.Sc. Honors – Queen’s University, Kingston, Ontario

Websites:
http://www.jibrankhokhar.com

Contact Information:

HB 7750
1 Medical Center Drive
Lebanon NH 03756

Office: (603)650-8544
Email: Jibran.Y.Khokhar@Dartmouth.edu


Courses Taught:

PSYC 50.09: Motivation, Drugs and Addiction

Biography:

I have a broad background in behavioral neuropharmacology, specifically in animal models of drug metabolism and alcohol abuse. As a post-doctoral fellow (and now as an Instructor in Psychiatry) at the Geisel School of Medicine at Dartmouth, working with Dr. Alan I. Green over the past four years, I have been working toward establishing safer and more efficacious therapeutics for co-occurring schizophrenia and alcohol use disorder. I am also working to develop novel animal models of schizophrenia and alcohol use disorder, while beginning to study the mechanisms underlying alcohol use in these models using behavioral and neuroimaging approaches. In particular, I received training in the laboratory of Dr. Patricio O’Donnell to allow me to create the NVHL rat model of substance use in schizophrenia. In addition, I received training in acquisition (and analysis) of magnetic resonance spectroscopy and resting state functional connectivity data in rats in the laboratory of Drs. Elliot Stein and Hanbing Lu, from NIDA IRP.

During my Ph.D. studies in the lab of Dr. Rachel F. Tyndale, I developed an animal model of selective modulation of brain cytochrome P450s (CYPs), and used this model to show, for the first time, that local metabolism by CYPs in the brain can meaningfully alter the disposition of, and response to, a centrally acting substrate. Using a variety of behavioral and molecular techniques, I investigated the role of these enzymes in local drug and toxin metabolism, and how this metabolism contributes to therapeutic efficacy, addiction, as well as neurotoxicity from these substrates. During my undergraduate studies at Queen’s University, I worked with Dr. Eric C. Dumont on the role of the BNST in the affective component of pain and morphine withdrawal.


Selected Publications:

 

An Open Source Automated Two-Bottle Choice Test Apparatus for Rats.
Frie JA, Khokhar JY
HardwareX. 2019 Apr;5 pii: e00061. doi: 10.1016/j.ohx.2019.e00061. Epub 2019 Apr 4.
PMID: 31245655

Finding the balance between model complexity and performance: Using ventral striatal oscillations to classify feeding behavior in rats.
Dwiel LL, Khokhar JY, Connerney MA, Green AI, Doucette WT
PLoS Comput Biol. 2019 Apr;15(4):e1006838. doi: 10.1371/journal.pcbi.1006838. Epub 2019 Apr 22.
PMID: 31009448

Machine Learning Based Classification of Deep Brain Stimulation Outcomes in a Rat Model of Binge Eating Using Ventral Striatal Oscillations.
Doucette WT, Dwiel L, Boyce JE, Simon AA, Khokhar JY, Green AI
Front Psychiatry. 2018;9:336. doi: 10.3389/fpsyt.2018.00336. Epub 2018 Aug 3.
PMID: 30123143

Unique Effects of Clozapine: A Pharmacological Perspective.
Khokhar JY, Henricks AM, Sullivan EDK, Green AI
Adv Pharmacol. 2018;82:137-162. doi: 10.1016/bs.apha.2017.09.009. Epub 2018 Jan 12.
PMID: 29413518

Addiction and schizophrenia: A translational perspective.
Green AI, Khokhar JY
Schizophr Res. 2018 Apr;194:1-3. doi: 10.1016/j.schres.2017.10.008. Epub 2017 Oct 16.
PMID: 29046253

Understanding marijuana's effects on functional connectivity of the default mode network in patients with schizophrenia and co-occurring cannabis use disorder: A pilot investigation.
Whitfield-Gabrieli S, Fischer AS, Henricks AM, Khokhar JY, Roth RM, Brunette MF, Green AI
Schizophr Res. 2018 Apr;194:70-77. doi: 10.1016/j.schres.2017.07.029. Epub 2017 Aug 18.
PMID: 28823723

The link between schizophrenia and substance use disorder: A unifying hypothesis.
Khokhar JY, Dwiel LL, Henricks AM, Doucette WT, Green AI
Schizophr Res. 2018 Apr;194:78-85. doi: 10.1016/j.schres.2017.04.016. Epub 2017 Apr 14.
PMID: 28416205

Behavioral predictors of alcohol drinking in a neurodevelopmental rat model of schizophrenia and co-occurring alcohol use disorder.
Khokhar JY, Todd TP
Schizophr Res. 2018 Apr;194:91-97. doi: 10.1016/j.schres.2017.02.029. Epub 2017 Mar 9.
PMID: 28285734

Effects of iloperidone, combined with desipramine, on alcohol drinking in the Syrian golden hamster.
Khokhar JY, Green AI
Neuropharmacology. 2016 Jun;105:25-34. doi: 10.1016/j.neuropharm.2016.01.017. Epub 2016 Jan 12.
PMID: 26796639

Nucleus accumbens deep brain stimulation in a rat model of binge eating.
Doucette WT, Khokhar JY, Green AI
Transl Psychiatry. 2015 Dec 15;5:e695. doi: 10.1038/tp.2015.197. Epub 2015 Dec 15.
PMID: 26670280

View more publications on PubMed