Jibran Y Khokhar, PhD
Adjunct Assistant Professor of Psychiatry
Lecturer in Psychological and Brain Sciences
Ph.D. – University of Toronto, Toronto, Ontario
Department of Pharmacology and Toxicology
Trainee at Centre for Addiction and Mental Health
B.Sc. Honors – Queen’s University, Kingston, Ontario
1 Medical Center Drive
Lebanon NH 03756
PSYC 50.09: Motivation, Drugs and Addiction
I have a broad background in behavioral neuropharmacology, specifically in animal models of drug metabolism and alcohol abuse. As a post-doctoral fellow (and now as an Instructor in Psychiatry) at the Geisel School of Medicine at Dartmouth, working with Dr. Alan I. Green over the past four years, I have been working toward establishing safer and more efficacious therapeutics for co-occurring schizophrenia and alcohol use disorder. I am also working to develop novel animal models of schizophrenia and alcohol use disorder, while beginning to study the mechanisms underlying alcohol use in these models using behavioral and neuroimaging approaches. In particular, I received training in the laboratory of Dr. Patricio O’Donnell to allow me to create the NVHL rat model of substance use in schizophrenia. In addition, I received training in acquisition (and analysis) of magnetic resonance spectroscopy and resting state functional connectivity data in rats in the laboratory of Drs. Elliot Stein and Hanbing Lu, from NIDA IRP.
During my Ph.D. studies in the lab of Dr. Rachel F. Tyndale, I developed an animal model of selective modulation of brain cytochrome P450s (CYPs), and used this model to show, for the first time, that local metabolism by CYPs in the brain can meaningfully alter the disposition of, and response to, a centrally acting substrate. Using a variety of behavioral and molecular techniques, I investigated the role of these enzymes in local drug and toxin metabolism, and how this metabolism contributes to therapeutic efficacy, addiction, as well as neurotoxicity from these substrates. During my undergraduate studies at Queen’s University, I worked with Dr. Eric C. Dumont on the role of the BNST in the affective component of pain and morphine withdrawal.
An Open Source Automated Two-Bottle Choice Test Apparatus for Rats.
Finding the balance between model complexity and performance: Using ventral striatal oscillations to classify feeding behavior in rats.
Machine Learning Based Classification of Deep Brain Stimulation Outcomes in a Rat Model of Binge Eating Using Ventral Striatal Oscillations.
Unique Effects of Clozapine: A Pharmacological Perspective.
Addiction and schizophrenia: A translational perspective.
Understanding marijuana's effects on functional connectivity of the default mode network in patients with schizophrenia and co-occurring cannabis use disorder: A pilot investigation.
The link between schizophrenia and substance use disorder: A unifying hypothesis.
Behavioral predictors of alcohol drinking in a neurodevelopmental rat model of schizophrenia and co-occurring alcohol use disorder.
Effects of iloperidone, combined with desipramine, on alcohol drinking in the Syrian golden hamster.
Nucleus accumbens deep brain stimulation in a rat model of binge eating.